Human epidermal Langerhans cells induce cellular immune response to trichophytin in dermatophytosis

Braathen, Lasse R.; Kaaman, T

doi:10.1111/j.1365-2133.1983.tb03544.x

Cited by 55 publications

(20 citation statements)

References 16 publications

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“…Numerous studies have suggested that LC represent a critical antimicrobial barrier in the skin against viral, bacterial, parasitic and fungal infections [8,11,13,26]. The present findings corroborate the finding of Nagao and Inaba [18] that LC are involved in the response of the skin to infection with VV.…”

supporting

confidence: 95%

Langerhans cells in vaccinia virus infection in mouse skin

Becker

Sprecher

1989

Archives of Virology

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Langerhans cells function as potent antigen-presenting cells in the epidermis. They were shown to play an essential role in the mechanisms of defense of the skin against viral infections. In the present study, the response of Langerhans cells to infection of the skin with vaccinia virus was investigated. Decrease in Langerhans cell density in the skin was accompanied by an increase in the pathogenicity of the WR and Noguchi but not of the Lister strain of vaccinia virus. Langerhans cell density was shown to increase rapidly at the site of inoculation with the two pathogenic strains of vaccinia virus.

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supporting

confidence: 95%

Langerhans cells in vaccinia virus infection in mouse skin

Becker

Sprecher

1989

Archives of Virology

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“…For the develop ment of allergic contact dermatitis, fungal antigens in the epidermis must be taken up and presented to T lympho cytes by Langerhans cells to induce antigen-specific responses. In vitro studies by Braathen and Kaaman [31] demonstrated that Langerhans cells are able to present dermatophyte antigens to T lymphocytes.…”

Section: Dermatophytosis As Contact Dermatitismentioning

confidence: 99%

Inflammation and Immunity in Dermatophytosis

Tagami¹,

Kudoh²,

Takematsu³

1989

Dermatology

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Infections by dermatophytes (dermatophytosis) naturally stimulate the immune system as in those by other microorganisms to induce various immunological phenomena. However, differing from other infections, the infecting organisms cannot become a direct target of antibody response or phagocytosis because they reside only in the barrier membrane of the body surface, i.e. in the stratum corneum.Thus, the immunity against dermatophytes is relative as compared with the absolute one noted in other infections such as measles and mumps. In dermatophytosis, a unique behavior of the epidermis as noted in contact dermatitis plays an important role in the defense against infection. Dermatitic changes induced by fungal products, particularly those due to contact sensitivity to a fungal antigen, trichophytin, enhance epidermopoiesis, which leads to increased turnover of the epidermis with their resultant elimination from the skin surface. Furthermore, the dermatophytes in the stratum corneum provoke transepidermal leukocyte chemotaxis by generating chemotactic C5a anaphylatoxin in exudating serum via alternative complement pathway activation in addition to a release of low molecular weight chemotactic factors. Such neutrophilic migration with the formation of subcorneal pustules also enhances epidermal proliferation as in psoriasis.

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“…Local immunologic factors have been considered to be involved but until now the theoretical background has been poorly understood. Langerhans' cells are thought to take part in the presentation of the antigen to the immune system and the occurance of Langerhans' cells in the palms and soles are reported to be reduced as compared to the skin of other parts of the body (2). However other local factors of resistence might also be of interest as shown by cases of keratoderma hereditaria where the stratum corneum of palms and soles is hypertrophic.…”

Section: Discussionmentioning

confidence: 99%

Hand, Foot and Nail Disease — a Common Manifestation of Chronic Dermatophytosis./Hand‐Fuß‐Nagel‐Befall — eine häufige Erscheinungsform der chronischen Dermatophytose

Kaaman

1988

Mycoses

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A retrospective study of 83 patients with dermatophytosis verified by culture and a duration of disease exceeding one year was performed. Among these chronic patients males dominated (70 %) and Trichophyton rubrum was isolated in 87 % of cases. Tinea pedis is no longer the most common exponent of chronicity. Multiple localization of lesions increased with the disease duration and in 67 % of chronic cases the infection started in the interdigital area, proceeded to the glabrous skin of the foot and to the toe-nails, finally affecting palms and fingernails. Predisposing factors were found in 19 % of the cases and atopy was registered in a few only. It appears that with the increasing incidence of T. rubrum infections a specific syndrome is developing in chronic patients characterized by affection of hand, food and nail with no obvious linking to atopy. Zusammenfassung: Es wurde eine retrospektive Verlaufsanalyse an 83 Patienten mit kulturell gesicherter Dermatophytose von mehr als ljahriger Dauer durchgefuhrt. Unter diesen chronisch kranken Patienten uberwogen Manner (70 %), und in 87% aller Falle war Trichophyton rubrum isoliert worden. Bei chronischer Dermatophytose ist die Tinea pedis nicht mehr die haufigste Erscheinungsform. Multiple Lokalisationen werden mit langerer Erkrankungsdauer haufiger, und bei 67 % chronischer Dermatophytosen beginnt die Infektion im Interdigitalraum, dehnt sich auf die glatte Haut der FuBe und auf die Zehennagel aus und befallt schlie6lich Palmarregion und Fingernagel. Pradisponierende Faktoren lagen bei 19 % der Patienten vor, Atopie wurde nur in wenigen Fallen gefunden. Offenbar entwickelt sich mit dem gehauften Auftreten von T. rubmm-Infektionen ein spezifisches Syndrom an chronisch-kranken Patienten, das durch den Hand-FuB-Nagel-Befall charakterisiert ist und keine Beziehung zur Atopie erkennen IaBt.

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Human epidermal Langerhans cells induce cellular immune response to trichophytin in dermatophytosis

Cited by 55 publications

References 16 publications

Langerhans cells in vaccinia virus infection in mouse skin

Langerhans cells in vaccinia virus infection in mouse skin

Inflammation and Immunity in Dermatophytosis

Hand, Foot and Nail Disease — a Common Manifestation of Chronic Dermatophytosis./Hand‐Fuß‐Nagel‐Befall — eine häufige Erscheinungsform der chronischen Dermatophytose

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