Human ESC‐derived immunity‐ and matrix‐ regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion

Zhao, Yilong; Wu, Jun; Li, Da; Liu, Jing; Chen, Weiqi; Hou, Zongren; Liu, Kailun; Jiang, Lingling; Chen, Xiaowei; Wang, Liu; Hu, Baoyang; Zong, Fangrong; Wang, Yukai; Wang, Yilong

doi:10.1111/cpr.13223

Cited by 7 publications

(2 citation statements)

References 68 publications

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“…The protective effects of AS-IV were reversed when TFEB was knocked down ( 136 ). The integrity of white matter bundles is vital for motor function recovery after SCI ( 137 ), as well as for neuronal communication and cognitive function improvement ( 138 ). Oligodendrocytes, which wrap around axons, form the basic structure of white matter bundles.…”

Section: Ros In Ferroptosismentioning

confidence: 99%

ROS: Executioner of regulating cell death in spinal cord injury

Yin,

Wan,

Gong

et al. 2024

Front. Immunol.

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The damage to the central nervous system and dysfunction of the body caused by spinal cord injury (SCI) are extremely severe. The pathological process of SCI is accompanied by inflammation and injury to nerve cells. Current evidence suggests that oxidative stress, resulting from an increase in the production of reactive oxygen species (ROS) and an imbalance in its clearance, plays a significant role in the secondary damage during SCI. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial regulatory molecule for cellular redox. This review summarizes recent advancements in the regulation of ROS-Nrf2 signaling and focuses on the interaction between ROS and the regulation of different modes of neuronal cell death after SCI, such as apoptosis, autophagy, pyroptosis, and ferroptosis. Furthermore, we highlight the pathways through which materials science, including exosomes, hydrogels, and nanomaterials, can alleviate SCI by modulating ROS production and clearance. This review provides valuable insights and directions for reducing neuronal cell death and alleviating SCI through the regulation of ROS and oxidative stress.

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Section: Ros In Ferroptosismentioning

confidence: 99%

ROS: Executioner of regulating cell death in spinal cord injury

Yin,

Wan,

Gong

et al. 2024

Front. Immunol.

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“…Prior research has demonstrated their potential in immunomodulation and tissue repair. For instance, the injection of IMRCs has the capability to suppress pulmonary inflammation and fibrosis following acute lung injury in vivo, 26 , 28 improve cognitive ability in early-stage AD mice, 29 prevent chronic cerebral hypoperfusion induced white matter injury and cognitive impairment, 30 ameliorate the progression of osteoarthritis, 31 etc. Meanwhile, IMRCs-derived extracellular vesicles and secretomes can attenuate pulmonary fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial

Huang,

Zhang,

et al. 2023

Sig Transduct Target Ther

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Immunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix, which could be mass-produced with stable biological properties. Despite resemblance to mesenchymal stem cells (MSCs) in terms of self-renew and tri-lineage differentiation, the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined. Here, we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury. Following injection into the knees of rabbits with meniscal injury, IMRCs enhanced endogenous fibrocartilage regeneration. In the dose-escalating phase I clinical trial (NCT03839238) with eighteen patients recruited, we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting. Furthermore, the effective results of magnetic resonance imaging (MRI) of meniscus repair and knee functional scores suggested that 5 × 107 cells are optimal for meniscus injury treatment. In summary, we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury. Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration.

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Systematic Review and Phenome‐Wide Scans of Genetic Associations with Vascular Cognitive Impairment

Diany,

Gagliano Taliun

2024

Advanced Biology

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Vascular cognitive impairment (VCI) is a heterogenous form of cognitive impairment that results from cerebrovascular disease. It is a result of both genetic and non‐genetic factors. Although much research has been conducted on the genetic contributors to other forms of cognitive impairment (e.g. Alzheimer's disease), knowledge is lacking on the genetic factors associated with VCI. A better understanding of the genetics of VCI will be critical for prevention and treatment. To begin to fill this gap, the genetic contributors are reviewed with VCI from the literature. Phenome‐wide scans of the identified genes are conducted and genetic variants identified in the review in large‐scale resources displaying genetic variant‐trait association information. Gene set are also carried out enrichment analysis using the genes identified from the review. Thirty one articles are identified meeting the search criteria and filters, from which 107 unique protein‐coding genes are noted related to VCI. The phenome‐wide scans and gene set enrichment analysis identify pathways associated with a diverse set of biological systems. This results indicate that genes with evidence of involvement in VCI are involved in a diverse set of biological functions. This information can facilitate downstream research to better dissect possible shared biological mechanisms for future therapies.

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Human ESC‐derived immunity‐ and matrix‐ regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion

Cited by 7 publications

References 68 publications

ROS: Executioner of regulating cell death in spinal cord injury

ROS: Executioner of regulating cell death in spinal cord injury

Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial

Systematic Review and Phenome‐Wide Scans of Genetic Associations with Vascular Cognitive Impairment

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