Human external ear canal as the specific reservoir of<i>Malassezia slooffiae</i>

Kaneko, Takamasa; Shiota, Ryoko; Shibuya, Shuichi; Watanabe, Shinichi; Umeda, Yoshiko; Takeshita, Kimiko; Yamamoto, Mami; Nishioka, Keiko; Makimura, Koichi

doi:10.3109/13693780903514880

Cited by 14 publications

(10 citation statements)

References 26 publications

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“…Recently, two interesting studies have been published, one showing that M. slooffiae is abundant in the human external auditory canal (21), and the other showing that M. slooffiae may cause otitis externa (22). In the present study, we showed by the highly accurate techniques of real‐time PCR and rRNA clone library analysis that M. slooffiae is the predominant species in both the external auditory canal and on the sole of the foot.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Malassezia microbiota in the human external auditory canal and on the sole of the foot

Zhang

Tanaka

Tsuboi

et al. 2012

Microbiology and Immunology

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Of the fungal skin microbiota, the lipophilic yeast genus Malassezia predominates at all body sites. Of the members of this genus, M. globosa, M. restricta, and M. sympodialis are the most common on the face, limbs, and trunk. In the present study, the Malassezia microbiotas in the external auditory canal and on the sole of the foot were characterized. M. slooffiae was the most common species in both the external auditory canal and on the sole of the foot, followed by M. restricta. Principal component analysis further revealed that the Malassezia microbiota in the external auditory canal and on the sole of the foot constitute a different cluster from those on the scalp and cheek and in the nasal cavity. Additionally, five new Malassezia phylotypes were detected on the sole of the foot and in the external auditory canal. Our results suggest that a distinctive Malassezia microbiota is present in the external auditory canal and on the sole of the foot, although the clinical significance of this finding remains unknown.

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Section: Discussionmentioning

confidence: 99%

Characterization of Malassezia microbiota in the human external auditory canal and on the sole of the foot

Zhang

Tanaka

Tsuboi

et al. 2012

Microbiology and Immunology

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“…More than 20 studies (Tables 3 to 6) have been carried out worldwide on the epidemiology of Malassezia species in cases of pityriasis versicolor, seborrheic dermatitis, atopic eczema, and psoriasis and on healthy control skin of the same individuals or skin from healthy volunteers (53,63,89,112,122,146,171,173,180,185,228,237,255,259,275,286,344,353). Results are not directly comparable between studies, as different methodologies, isolation media, and identification procedures have been employed.…”

Section: Culture-based Epidemiologymentioning

confidence: 99%

The Malassezia Genus in Skin and Systemic Diseases

et al. 2012

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SUMMARY In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur , M. pachydermatis , M. sympodialis , M. globosa , M. obtusa , M. restricta , and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis , M. japonica , M. yamatoensis , M. nana , M. caprae , M. equina , and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species and skin diseases. Hitherto, basic and clinical research has established etiological links between Malassezia yeasts, pityriasis versicolor, and sepsis of neonates and immunocompromised individuals. Their role in aggravating seborrheic dermatitis, dandruff, folliculitis, and onychomycosis, though often supported by histopathological evidence and favorable antifungal therapeutic outcomes, remains under investigation. A close association between skin and Malassezia IgE binding allergens in atopic eczema has been shown, while laboratory data support a role in psoriasis exacerbations. Finally, metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia -synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis.

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“…Shiota et al (2009) reported the presence of this yeast in 5 of 63 patients with otitis (Shiota et al, 2009). The presence of M. slooffiae and M. restricta in the external auditory canal of clinically healthy people (Kaneko et al, 2010) while presence of M. sympodialis in a diabetic patient with external otitis has also been reported (Chai et al, 2000). Sugita et al (2013) reported the presence of M. globosa and M. restricta in lesions of the external auditory canal and sole of the foot (Sugita et al, 2013, Zhang et al, 2012.…”

Section: Discussionmentioning

confidence: 96%

“…However, there are few reports of this yeast in human cases of external otitis (Kaneko et al, 2010) and no reports of lipophilic Malassezia as causing agent of otitis media in infants and adults. Therefore, the aim of this work was to report the isolation and identification of Malassezia by PCR amplification and sequencing of the D1/D2 region of DNA encoding the LSU rRNA in two infants with a clinical diagnosis of otitis media.…”

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confidence: 99%