For existing United States nuclear power plant fleet to remain economically viable, the nuclear industry needs to fundamentally change the way in which these plants are operated, maintained, and supported. A digital transformation is a key strategy to address this challenge. Though, guidance in this area is a continued effort. One framework to support innovation in the nuclear industry has taken a broader perspective by focusing on how technology can be used to meet specific business needs and work for the people and processes at hand. This work discusses the role and value of human factors engineering within this nuclear innovation framework. Human factors methods are presented here regarding how they address the phases of nuclear innovation. This work seeks to describe how human factors can be applied in nuclear innovation by strengthening the alignment of technology, people, processes, and regulations such that the needs of the business is addressed.