Human genes involved in lipolysis of plasma lipoproteins: Mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21

Lipoprotein lipase gene S447X polymorphism modulates the relation between central obesity and serum lipids, a twin study

“…5 Up to now, several genes, including ApoE and ApoB, 6,7 have been reported their possible influence on the relations between obesity and lipid levels, but researches about the influence of Lipoprotein lipase (LPL) gene S447X polymorphism on the relation of obesity and lipid levels were controversial. [8][9][10] Human LPL gene is located on chromosome 8p22, 11 and S447X polymorphism is a nonsense mutation with a serine substitution by a stop codon in exon 9 of LPL gene and caused two amino acids truncated LPL molecule. 12 Although results from in vivo or in vitro studies of S447X polymorphism are not entirely consistent, 8,13 it has been reported that this polymorphism may result in higher LPL activity.…”

Distribution géographique de certains polymorphismes associés à des maladies inflammatoires chroniques dans les régions administratives du Québec /

“…Le gène de la lipase lipoprotéique (LPL) a été localisé et séquence pour la première fois en 1987 (Sparkes et al, 1987;Wion et al, 1987 , 1980). Des études antérieures laissent supposer que la LPL pourrait avoir un rôle dans le processus de l'athérosclérose Steinberg, 1983).…”

Candidate Genes in Hypertension

“…LPL gene located on chromosome 8p22 (Sparkes et al, 1987), has a length of 30 kb (Deeb & Peng, 1989), is composed of 10 exons. Mutations in locus intron 6 of LPL gene (Oka et al, 1989, Zuliani & Hobbs, 1990 lead to hypertriglyceridemia, dyslipidemia leading to various disorders as coronary artery disease, hypertension and obesity.…”