Human Herpesvirus 6 Is Present in Lesions of Langerhans Cell Histiocytosis

Leahy, Maureen A.; Krejci, Sonja M; Friednash, M; Stockert, Stephen S.; Wilson, Harry; Huff, J. Clark; Weston, William L.; Brice, Sylvia L.

doi:10.1111/1523-1747.ep12371669

Cited by 91 publications

(49 citation statements)

References 31 publications

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“…In contrast, Leahy et al (16) detected HHV-6 in 47% of their patients with LCH, using the PCR technique. Glotzbecker et al (15) used the immunohistochemistry (IHC) method and ISH for detection of HHV-6, and reported a high rate of 71.4% by both methods.…”

Section: Discussionmentioning

confidence: 91%

“…The etiologic role of HHV-6 in LCH is debated, with conflicting results in the literature (14)(15)(16)(17)(18)(19). Jeziorski et al (17) demonstrated no significant association between EBV, CMV, or HHV-6 in the pathogenesis of LCH.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies (14)(15)(16)(17)(18)(19), authors have declared no limitations, and their methods included serology, IHC, ISH, and PCR. However, the limitations of our study were that IHC and ISH for HHV-6 were not available for use and the patients could not be checked for the evidence of HHV-6 infections serologically.…”

Section: Discussionmentioning

confidence: 99%

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Human Herpesvirus-6 DNA and Langerhans Cell Histiocytosis

Khoddami

Nadji

Vahdatinia

2016

Arch Pediatr Infect Dis

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Background: Langerhans cell histiocytosis (LCH) is a rare histiocytic proliferative disorder of unknown etiology that mainly affects young children. The histological feature is the granuloma-like proliferation of Langerhans-type dendritic cells. The possible role of viruses such as Epstein-Barr virus (EBV, HHV-4), human herpesvirus-6 (HHV-6), herpes simplex virus (HSV) types 1 and 2, and cytomegalovirus (CMV, HHV-5) in the pathogenesis of LCH has been suggested in some studies; however, this still remains under debate.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Human Herpesvirus-6 DNA and Langerhans Cell Histiocytosis

Khoddami

Nadji

Vahdatinia

2016

Arch Pediatr Infect Dis

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“…The precise causes of most histiocytoses are not known, but infections, particularly viral [7], cellular and immune dysfunctions [8] have been implicated in the etiology and pathophysiology of this disorder. Källén et al, reported an increased rate of diagnosed histiocytosis in children conceived by means of in vitro fertilization, 6 cases of Langerhans histiocytosis against 1.0 expected [9].…”

Section: Discussionmentioning

confidence: 99%

Unusual Acute Onset of Symptomatic Langerhans Cell Histiocytosis of the Skull: Case Report and Literature Review

Kaloostian¹,

Chen²,

Westhout³

et al. 2013

OJMN

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Introduction: Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized bone marrow-derived Langerhans cells (LCs) and mature eosinophils, resulting in solitary or few, indolent and chronic, lesions of bone or other organs called eosinophilic granulomas. Calvarial LCH is quite rare and an underappreciated differential etiology of skull lesions. We present a most unusual case of a young child with hyperacutely symptomatic langerhans histiocytosis of the skull. Method: A 7-year-old male presented with a history of increasing (progressive) frontal headaches of 8 days duration, unaccompanied by associated nausea, vomiting, or diplopia. His only additional complaint was a hard bump on his forehead. MRI and CT done in the ER identified a right fronto-parietal lesion with associated skull erosion. Nuclear medicine and SPECT studies confirmed an erosive skull lesion without significant metabolic activity. A right frontal craniectomy and excision was performed. Results: A soft, rubbery well-circumcised mass coming from the diploic layer of the skull with involvement of bone was identified. The mass had eroded both the outer and inner table of the skull, and the involved area of the right frontal bone was resected. Intra-operative histo-pathologic analysis of the lesion revealed Langerhans cell histiocytosis without involvement of the dura. The patient experienced no neurological worsening as a result of the resection. He was discharged home in stable condition. Conclusion: LCH lesions of the skull are common findings, however, this focal hyperacute symptomatic presentation is most rare and should not deter us from anticipating an erosive bony tumor and planning timely surgical management.

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“…HHV-6 genomes and antigens are detectable in lymph nodes of patients with sinus histiocytosis with massive lymphadenopathy tubular epithelial cells, endothelial cells and histiocytes in kidney salivary glands and central nervous system tissues, where viral gene products have been localized to neurons and oligodendrocytes (Levine et al, 1992;Kurata et al, 1990). HHV-6 is also detected in lesions of Langerhans cell histiocytosis in the syndrome of Langerhans cell histiocytosis (Leahy et al, 1993;Csire et al, 2007a).…”

Section: Epidemiologymentioning

confidence: 99%