Human Herpesvirus 8–Associated Solid Lymphomas that Occur in AIDS Patients Take Anaplastic Large Cell Morphology

Katano, Harutaka; Suda, Tetsuji; Morishita, Yasuyuki; Yamamoto, Katsuya; Hoshino, Yoshihiko; Nakamura, Koichiro; Tachikawa, Natsuo; Sata, Tetsutaro; Hamaguchi, Hiroyuki; Iwamoto, Aikichi; Mori, Shigeki

doi:10.1038/modpathol.3880012

Cited by 88 publications

(51 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Extraserous involvement of PEL has already been reported as well as visceral localizations of anaplasticlike KSHV/HHV8 ϩ NHL. [30][31][32] The illegitimate expression of T-cell markers has already been reported in some PEL cells. 31,33 In contrast with more than 85% of the HIV-associated "classic" PELs, these tumors were EBV Ϫ , suggesting that, in the pathogenesis of PEL, the dual infection with KSHV/HHV8 and EBV may be involved in the peculiar tropism of the tumor.…”

Section: Discussionmentioning

confidence: 99%

High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

Oksenhendler

Boulanger

Galicier

et al. 2002

Blood

368

270

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

Oksenhendler

Boulanger

Galicier

et al. 2002

Blood

368

270

View full text Add to dashboard Cite

“…Recently, the spectrum of KSHV/HHV8-associated lymphoproliferative diseases in the HIV setting has been expanded by the identification of cases of KSHV/HHV8-associated extracavitary lymphomas without serous effusions (Baylot-Barry et al, 1999;Beaty et al, 1999;Morand et al, 1999;Katano et al, 2000;Aboulafia, 2002;Costes et al, 2002;Engels et al, 2003;Navarro et al, 2003;Carbone et al, 2005a). These lymphomas were generally composed of a proliferation of immunoblasticlike cells, but, in some cases, the neoplastic cells showed greater pleomorphism and anaplastic features (Table I).…”

Section: Pel and Kshv/hhv 8-associated Solid Lymphomasmentioning

confidence: 99%

KSHV/HHV8‐associated lymphomas

2007

View full text Add to dashboard Cite

SummaryThis review looks at the current state of knowledge on primary effusion lymphoma (PEL) and other Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus 8 (HHV8)‐associated lymphomas. In 1995, KSHV DNA sequences were identified within a distinct subgroup of acquired immunodeficiency syndrome‐related non‐Hodgkin lymphomas localized in body cavities and presenting as pleural, peritoneal and pericardial lymphomatous effusions. Subsequently, the spectrum of KSHV/HHV8‐associated lymphomas has been expanded by the identification of cases of extracavitary solid lymphomas without serous effusions. Despite the diversification in the clinical presentation of KSHV/HHV8‐associated lymphomas, the majority of the cases reported demonstrated similar morphology, immunophenotype and KSHV/HHV8 viral status. KSHV/HHV8 infection is also in multicentric Castleman disease‐associated plasmablastic lymphoma. The exact oncogenic mechanisms of KSHV/HHV8 are not clearly defined. The prognosis for KSHV/HHV8‐associated lymphomas is poor. Novel approaches for therapy, outside traditional chemotherapy with CHOP (cyclophosphamide, doxorubicin, prednisone, vincristine), have been suggested. These include the addition of antiviral therapy as well as inhibition of specific cellular targets.

show abstract

“…Recently, KSHV/HHV-8 has been detected by immunohistochemistry and/or polymerase chain reaction in lymphoma cases presenting as tissue masses in persons with multicentric Castleman’s disease [6,7,8,9] or AIDS-associated KS [9,10,11,12,13]. These lymphomas were described histologically as diffuse large-cell lymphoma or immunoblastic lymphoma with a PEL-like morphology.…”

Section: Introductionmentioning

confidence: 99%

HHV-8-Associated Lymphoma: State-of-the-Art Review

Carbone

Gloghini

2006

Acta Haematol

View full text Add to dashboard Cite

During the first decade after the discovery of primary effusion lymphoma (PEL), sporadic and serial reports suggested that Kaposi-sarcoma-associated-herpesvirus/human-herpesvirus-8 (KSHV/HHV-8)-associated lymphomas in their liquid and solid presentation are clinically distinct, representing part of the spectrum of PEL. In HIV-seropositive patients with serous effusions, these solid lymphomas were reported before the development of an effusion lymphoma and following resolution of PEL. More recently, solid lymphomas not associated with lymphomatous effusion have been found in HIV-seropositive and HIV-seronegative patients. Despite the diversification in the clinical presentation of KSHV/HHV-8-associated lymphomas, most cases demonstrated a similar morphology, immunophenotype and KSHV/HHV-8 viral status.

show abstract

Human Herpesvirus 8–Associated Solid Lymphomas that Occur in AIDS Patients Take Anaplastic Large Cell Morphology

Abstract: Human herpesvirus type 8 (HHV-8; Kaposi's sarcoma-associated herpesvirus) is a recently isolated human herpesvirus frequently identified in

Cited by 88 publications

References 33 publications

High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

KSHV/HHV8‐associated lymphomas

HHV-8-Associated Lymphoma: State-of-the-Art Review

Contact Info

Product

Resources

About