Human herpesvirus 8 DNA detection and variant analysis in patients with multiple sclerosis

Marashi, Sayed Mahdi; Mostafa, Aliehossadat; Shoja, Zabihollah; Nejati, Ahmad; Shahmahmoodi, Shohreh; Mollaei-Kandelous, Yaghoub; Sahraian, Mohammad Ali; Jalilvand, Somayeh

doi:10.1007/s13337-018-0481-1

Cited by 7 publications

(5 citation statements)

References 18 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As we mentioned before numerous studies have reported an interaction between viral infection and neural cells leading to multiple sclerosis. Marashi et al (2018) examined peripheral blood looking for DNA sequences of HHV-8 in 54 multiple sclerosis patients and 130 healthy subjects, detecting the virus in 18.5% of the patients and 3% of controls. HHV-8 infection has also been reported in patients with acquired immune deficiency syndrome (AIDS) associated with Kaposi sarcoma (Corbellino et al, 1996;Ogoina et al, 2011).…”

Section: Klks Associated To Viral Infections That Can Affect the Cnsmentioning

confidence: 99%

Involvement of Kallikrein-Related Peptidases in Nervous System Disorders

Mella

Figueroa

Otth

et al. 2020

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Kallikrein-related peptidases (KLKs) are a family of serine proteases that when dysregulated may contribute to neuroinflammation and neurodegeneration. In the present review article, we describe what is known about their physiological and pathological roles with an emphasis on KLK6 and KLK8, two KLKs that are highly expressed in the adult central nervous system (CNS). Altered expression and activity of KLK6 have been linked to brain physiology and the development of multiple sclerosis. On the other hand, altered levels of KLK6 in the brain and serum of people affected by Alzheimer's disease and Parkinson's disease have been documented, pointing out to its function in amyloid metabolism and development of synucleinopathies. People who have structural genetic variants of KLK8 can suffer mental illnesses such as intellectual and learning disabilities, seizures, and autism. Increased expression of KLK8 has also been implicated in schizophrenia, bipolar disorder, and depression. Also, we discuss the possible link that exists between KLKs activity and certain viral infections that can affect the nervous system. Although little is known about the exact mechanisms that mediate KLKs function and their participation in neuroinflammatory and neurodegenerative disorders will open a new field to develop novel therapies to modulate their levels and/or activity and their harmful effects on the CNS.

show abstract

Section: Klks Associated To Viral Infections That Can Affect the Cnsmentioning

confidence: 99%

Involvement of Kallikrein-Related Peptidases in Nervous System Disorders

Mella

Figueroa

Otth

et al. 2020

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The Kaposi sarcoma-associated herpes virus infection pathways were enriched in the gene set uploaded. A study showed that the human herpes virus 8 genomes were detected in 10 out of 54 individuals with MS and 4 out of 130 control samples when nested PCR was performed (Marashi et al, 2018). Forkhead box O1 in short FoxO signaling pathway was also enriched in the geneset.…”

Section: Common Enriched Kegg Pathwaysmentioning

confidence: 99%

Identifying common genes, proteins, and pathways from human miRNA and gene blood profiles in multiple sclerosis patients

Chakraborty¹,

Maiti²,

Bhowmick³

et al. 2022

Preprint

View full text Add to dashboard Cite

The molecular pathway associated with Multiple sclerosis (MS) is complex and symptomatic treatments are only available right now. Early diagnosis of MS creates a window for healthcare providers to manage the disease more efficiently. Blood-based biomarker study has been done in the past to identify the upregulated and downregulated genes but in this present study, a novel approach has been taken for identifying genes associated with the disease. In this present study, hub genes are identified and the top ten hub genes were used to identify drugs associated with them. Upregulated genes were identified using the dataset GSE21942 (which contains information related to genes identified in the blood of multiple sclerosis patients) and datasets GSE17846 and GSE61741(which contains information related to microRNAs taken from multiple sclerosis patients). Genes associated with microRNAs were identified using miRWalk. Common genes from both miRWalk and the dataset GSE21942 were identified and were subjected to STRINGdb for the creation of a protein-protein interaction network and this network was then imported to Cytoscape for identifying the top ten hub genes. The top ten hub genes were subjected to EnrichR for enrichment analysis of genes. In our study, it was found that CTNNB1 is the gene with the highest degree (116).

show abstract

“…Oligoclonal bands (OCBs) directed against HHV-6 and EBV have been identified in MS patients [ 149 ], and OCBs against HSV-1 in the CSF of MS patients has also been reported [ 150 ], although this was not corroborated in all studies [ 151 ]. HSV-1 has been linked to demyelination in animal models [ 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 ] and in humans [ 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 ], and several studies have suggested other herpesviruses including HHV-6 [ 146 , 164 , 169 , 170 , 171 , 172 , 173 , 174 ], EBV [ 144 , 175 , 176 , 177 , 178 , 179 , 180 , 181 ] and HHV-8 [ 168 , 170 , 182 ] are risk factors for MS. In general, herpesvirus infections are more frequent in MS patients than in patients with other neurological diseases [ 138 ].…”

Section: Human Endogenous Retroviruses (Hervs)mentioning

confidence: 99%

HSV-1 and Endogenous Retroviruses as Risk Factors in Demyelination

Bello-Morales

Andreu

Ripa

et al. 2021

IJMS

View full text Add to dashboard Cite

Herpes simplex virus type 1 (HSV-1) is a neurotropic alphaherpesvirus that can infect the peripheral and central nervous systems, and it has been implicated in demyelinating and neurodegenerative processes. Transposable elements (TEs) are DNA sequences that can move from one genomic location to another. TEs have been linked to several diseases affecting the central nervous system (CNS), including multiple sclerosis (MS), a demyelinating disease of unknown etiology influenced by genetic and environmental factors. Exogenous viral transactivators may activate certain retrotransposons or class I TEs. In this context, several herpesviruses have been linked to MS, and one of them, HSV-1, might act as a risk factor by mediating processes such as molecular mimicry, remyelination, and activity of endogenous retroviruses (ERVs). Several herpesviruses have been involved in the regulation of human ERVs (HERVs), and HSV-1 in particular can modulate HERVs in cells involved in MS pathogenesis. This review exposes current knowledge about the relationship between HSV-1 and human ERVs, focusing on their contribution as a risk factor for MS.

show abstract

Human herpesvirus 8 DNA detection and variant analysis in patients with multiple sclerosis

Cited by 7 publications

References 18 publications

Involvement of Kallikrein-Related Peptidases in Nervous System Disorders

Involvement of Kallikrein-Related Peptidases in Nervous System Disorders

Identifying common genes, proteins, and pathways from human miRNA and gene blood profiles in multiple sclerosis patients

HSV-1 and Endogenous Retroviruses as Risk Factors in Demyelination

Contact Info

Product

Resources

About