Human Herpesvirus 8 Genotype E in Patients with Kaposi Sarcoma, Peru

Cassar, Olivier; Blondot, Marie Lise; Mohanna, Salim; Jouvion, Grégory; Bravo, Francisco; Maco, Vicente; Duprez, Renan; Huerre, Michel; Gotuzzo, Eduardo; Gessain, Antoine

doi:10.3201/eid1609.100381

Cited by 20 publications

(19 citation statements)

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“…This is also shown in Fig. 1 regions, 33 using two separate fragments-VR1 and VR2-to produce two phylogenetic trees, 12,39 or considering VR1 region only. 40,41 In South America, several studies have analyzed the genetic variation of HHV-8 ORFK1; subtypes A, A5, B, C, and E were described in Brazil 15,39,42 ; subtypes A, B, C, and E 12 in Peru, and subtype E was described in French Guiana and Ecuador.…”

Section: Resultsmentioning

confidence: 76%

“…5 Subtypes A and C were found predominantly in Europe, United States, Middle East, and Asia, A5 and B were reported almost exclusively in individuals of African heritage, whereas the rare subtype D was found only in KS patients of Pacific Island inheritance and subtype E was described in Amerindians and KS patients from Cuba. [8][9][10][11][12][13][14] South America is a continent with a wide spectrum of ethnicity derived from migratory flows from Africa, 2020 |…”

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confidence: 99%

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Diversity of human herpesvirus 8 genotypes in patients with AIDS and non-AIDS associated Kaposi's sarcoma, Castleman's disease and primary effusion lymphoma in Argentina

Perez

Tous

2017

J Med Virol

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HHV-8 genotypes are distributed heterogeneously worldwide. The variable K1 gene and the conserved ORF26E region serve to genotype. The aim of the study was to characterize HHV-8 isolates from patients with AIDS, classical, and iatrogenic KS, primary effusion lymphoma and Castleman's disease and one organ donor from Argentina by analysis of ORFK1 and ORF26E regions. DNA was extracted from fresh or paraffin embedded biopsies, blood, and saliva samples and submitted to HHV-8 PCR. Phylogenetic analyses of ORFK1 showed that subtypes C (C1, C2, and C3), B1 and A (A1, A2, and A3) were present in 70.8%, 16.7%, and 12.5% of cases, respectively. Analyses of ORF26E fragment revealed that most strains (45.8%) were subtype A/C while the remaining fall into K, J, B2, R, and D subtypes. Linkage between ORFK1-ORF26E subtypes corresponded to reported relationships, except for one strain that clustered with B1 (K1 African) and D (ORF26E Asian-Pacific) subtypes. This research reveals predominance of subtype C, a broad spectrum of HHV-8 genotypes and reports the first isolation of the African B genotype in Argentina.

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Section: Resultsmentioning

confidence: 76%

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confidence: 99%

Diversity of human herpesvirus 8 genotypes in patients with AIDS and non-AIDS associated Kaposi's sarcoma, Castleman's disease and primary effusion lymphoma in Argentina

Perez

Tous

2017

J Med Virol

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“…It commonly occurs in the context of HIV-1 infection and in immunosuppressed patients. Classic KS affects elderly men of Mediterranean and Middle Eastern descent; the endemic variant is found in Central Africa [ 2 ] .…”

Section: Discussionmentioning

confidence: 99%

Slowly growing exophytic hyperpigmented nodule of the calf

Crişan

Sindrilaru

Badea

et al. 2018

J Deutsche Derma Gesell

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An 84-year-old male Caucasian patient presented with an exophytic pigmented tumor on his right calf. The lesion had started out as a pigmented patch one year earlier, and had subsequently evolved into a bleeding tumor. Clinical examination revealed a hyperpigmented, ulcerated, pedunculated lesion (3 × 3.5 cm) arising from a brownish patch. In the vicinity of the tumor, there were several pale-violaceus nodular lesions that were nontender to palpation (Figure 1 ).

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“…A low seroprevalence was found in the general population of Russia (0-5 %) [ 180 ], Czech Republic (0.3-2.4 %) [ 386 ], and Hungary (2 %) [ 209 ], whereas higher rates (25 %) were reported in an adult population of Southern Siberia [ 65 ].…”

Section: Epidemiology Of Kshv Infectionmentioning

confidence: 99%

Kaposi’s Sarcoma-Associated Herpesvirus: Epidemiology, Biological Characteristics and Pathogenesis

Sarid

Calabrò

2014

Viral Infections of Humans

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KSHV is a lymphotropic gamma-2 herpesvirus (rhadinovirus) and is the only member of this group that infects humans. KSHV shares close homology with several primate and nonprimate mammalian viruses, having the closest homology with retroperitoneal fi bromatosis herpesviruses (RFHV) and rhesus rhadinovirus (RRV) [ 110 , 347 , 363 ]. Among human herpesviruses, KSHV is most closely related to the EpsteinBarr virus (EBV), a ubiquitous lymphotropic virus which is associated causally with several human cancers, including nasopharyngeal carcinoma and certain types of lymphomas.The overall size of the KSHV virion is 120-150 nm. Four structural proteins encoded by the orf 25 , orf26 , orf62 , and orf65 encompass the icosahedral capsid shell of KSHV which has a diameter of ~130 nm. Three of these proteins share signifi cant homology with capsid proteins in alpha and beta-herpesvirus subfamilies, whereas ORF65 differs from its structural counterparts in the other subfamilies [ 397 ]. Cryo-electron microscopy (Cryo-EM) and Cryo-EM tomography studies suggest that KSHV capsomers are hexamers and pentamers of the major capsid protein encoded by orf25 , with the small capsid protein, encoded by orf65 , binding around the tips of both hexons and pentons [ 108 ]. An amorphous, but highly organized, proteinaceous tegument, wrapped with a lipid bilayer envelope containing surface viral glycoproteins, surrounds the capsid. Several cellular

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Human Herpesvirus 8 Genotype E in Patients with Kaposi Sarcoma, Peru

Cited by 20 publications

References 14 publications

Diversity of human herpesvirus 8 genotypes in patients with AIDS and non-AIDS associated Kaposi's sarcoma, Castleman's disease and primary effusion lymphoma in Argentina

Diversity of human herpesvirus 8 genotypes in patients with AIDS and non-AIDS associated Kaposi's sarcoma, Castleman's disease and primary effusion lymphoma in Argentina

Slowly growing exophytic hyperpigmented nodule of the calf

Kaposi’s Sarcoma-Associated Herpesvirus: Epidemiology, Biological Characteristics and Pathogenesis

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