Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes

Saint-Cricq, Maximilien; Carrete, Jesús; Gaboriaud, Christine; Gravel, Edmond; Doris, Eric; Thielens, Nicole M.; Mingo, Natalio; Ling, Wai Li

doi:10.1021/acs.nanolett.7b00189

Cited by 14 publications

(18 citation statements)

References 33 publications

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“…Several studies have shown that C1q binds to nanomaterial surfaces, though this binding does not necessarily lead to complement activation [reviewed in (7)]. Recent modeling studies suggested that C1q is able to disaggregate bundles of multi-walled CNTs, but not those of thin, single-walled CNTs and these predictions were validated with experimental observations (45). These findings may be relevant for the toxicity of CNTs irrespective of whether or not complement is activated, as the (pulmonary) toxicity of CNTs was suggested to be attributable to aggregation of the CNTs rather than the high aspect ratio of individual nanotubes (46).…”

Section: Immune Evasionmentioning

confidence: 88%

Hide and Seek: Nanomaterial Interactions With the Immune System

Fadeel

2019

Front. Immunol.

103

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Engineered nanomaterials hold promise for a wide range of applications in medicine. However, safe use of nanomaterials requires that interactions with biological systems, not least with the immune system, are understood. Do nanomaterials elicit novel or unexpected effects, or is it possible to predict immune responses to nanomaterials based on how the immune system handles pathogens? How does the bio-corona of adsorbed biomolecules influence subsequent immune interactions of nanomaterials? How does the grafting of polymers such as poly(ethylene glycol) onto nanomaterial surfaces impact on these interactions? Can ancient immune evasion or “stealth” strategies of pathogens inform the design of nanomaterials for biomedical applications? Can nanoparticles co-opt immune cells to target diseased tissues? The answers to these questions may prove useful for the development of nanomedicines.

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Section: Immune Evasionmentioning

confidence: 88%

Hide and Seek: Nanomaterial Interactions With the Immune System

Fadeel

2019

Front. Immunol.

103

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“…A more recent simulation study, supported by experimental results, does also suggest that a globular protein may also disaggregate large bundles of multi-walled CNT with a large diameter, but not the single-walled CNT with a small diameter [16]. The chosen protein was a globular domain of C1q, a large multifunctional protein formed by six well separated globular domains, gC1q, each connected to a collagen stem that eventually form a single fibril.…”

Section: Carbon Nanotubes (Cnt)mentioning

confidence: 86%

“…Chiral CNT are characterized by (n, m) indices with n s m: in chemical terms, enantiomeric chiral nanotubes have swapped indices (n, m) and (m, n), and can interact with chiral molecules such as the oligopeptides forming in principle complexes with an unlike stability. The selected CNT were the (10,20) and the (20, 10) CNT with a diameter of 2.07 nm, while an armchair (16,16) CNTwith a very similar diameter was also considered for a comparison. The MD simulations, carried out in an implicit solvent, considered four starting oligopeptide orientations close the outer CNT convex surface, and other four ones close to the CNT open end, but outside the inner cavity, to model adsorption on the concave surface if encapsulation took place in the MD run.…”

Section: Graphene and Graphynementioning

confidence: 99%

Classical atomistic simulations of protein adsorption on carbon nanomaterials

Raffaini

2019

Current Opinion in Colloid & Interface Science

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Carbon nanomaterials are receiving an increasingly large interest in a variety of fields, including also nanomedicine. In this area, much attention is devoted to investigating and modeling the behavior of these nanomaterials when they interact with biological fluids and with biological macromolecules, in particular proteins and oligopeptides. The interaction with these molecules is in fact crucial to understand and predict the efficacy of nanomaterials as drug carriers or therapeutic agents as well as their potential toxicity when they occupy the active site of a protein or severely affect the secondary and tertiary structure, or even the local dynamics, thus inhibiting their biological function. In this review, therefore, we describe the most recent work carried out in the last few years to model the interaction between carbon nanomaterials, either pristine or functionalized, and proteins or oligopeptides using classical atomistic methods, mainly molecular dynamics simulations. The attention is focused on 0dimensional fullerenes, mainly C 60 , on 1-dimensional carbon nanotubes, mostly the single-walled armchair and some chiral ones, and on 2-dimensional graphene and graphyne, the latter containing also sp hybridized atoms in addition to the sp 2 ones common to the other carbon nanomaterials.

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“…If it is necessary to handle nanoparticle powders outside of a high-efficiency particulate air filtered to maintain exhaust streamline flow hood. Lab equipment and exhaust systems should also be evaluated before removal, remodeling, or repair [26,27]. Given the differing artificial ways and experimental goals, no blanket recommendation will be created concerning aerosol emissions controls.…”

Section: Strategy For Functioning With Nanomaterialsmentioning

confidence: 99%

Nanosafety

Yuvaraj¹,

Yuvaraj²,

Arunkumar³

et al. 2020

Biochemical Toxicology - Heavy Metals and Nanomaterials

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The nanomaterials resembling nanotubes, nanospheres, nanofertilizer, nanoherbicide, nanoinsecticide, and nanosheets have the physical, chemical, biological, mechanical, electrical and thermal properties. Still, the nanoparticles have very minute dimensions, enormous area and high reactivity they need the potential ability to penetrate in living cells quite rapidly. The petite size nanoparticles contain lofty surface area may cause higher reactivity with nearby particles. It is broadly predictable that there is a critical need for more information and facts about the implications of manufactured nanomaterials on personal fitness and surroundings. Concerns about potential risks to health that may arise during the making, management, use, and discarding of these nanomaterials have been spoken over the past few years. Consequently, strong research action is being undertaken in various institutions, and industries across the world to appraise their toxicity and spread of nanoparticle.

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Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes

Cited by 14 publications

References 33 publications

Hide and Seek: Nanomaterial Interactions With the Immune System

Hide and Seek: Nanomaterial Interactions With the Immune System

Classical atomistic simulations of protein adsorption on carbon nanomaterials

Nanosafety

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