Human Immunodeficiency Virus Disease Severity, Psychiatric Symptoms, and Functional Outcomes in Perinatally Infected Youth

Nachman, Sharon; Chernoff, Miriam; Williams, Paige L.; Hodge, Janice; Heston, Jerry; Gadow, Kenneth D.

doi:10.1001/archpediatrics.2011.1785

Cited by 74 publications

(78 citation statements)

References 18 publications

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“…The pattern of group differences on speeded measures was observed previously in a more limited set of EF measures for the entire AMP cohort [31]. It is also consistent with a larger literature that shows that processing speed is a cognitive domain at particular risk for those with HIV infection [6,13,[32][33][34][35]. Processing speed has demonstrated associations with markers of both past [29] and ongoing disease processes, such as functional connectivity using functional magnetic resonance imaging [36], brain metabolites [14], and biomarkers of vascular functioning [37], in youth with PHIV.…”

Section: Discussionsupporting

confidence: 87%

Executive Functioning in Children and Adolescents With Perinatal HIV Infection and Perinatal HIV Exposure

et al. 2016

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Section: Discussionsupporting

confidence: 87%

Executive Functioning in Children and Adolescents With Perinatal HIV Infection and Perinatal HIV Exposure

et al. 2016

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“…HIV vertical transmition (40,42,(45)(46) Grave sexual violence (13,29,51) HIV risk behaviors (20,43,46) Early sexual activity (42) Problems to adhere to antiretroviral treatment (42) 16.9 function in its psychic structuring. The family relationships containing affection and good communication are protection factors determinants to the adolescent mental health (31) .…”

Section: Std/aids Relatedmentioning

confidence: 99%

Risk factors associated with mental health issues in adolescents: a integrative review

Pinto

Luna

Sivla

et al. 2014

Rev. esc. enferm. USP

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Objective: To identify the risk factors associated with mental health issues in adolescents. Method: An integrative review was conducted in four databases with publications from 2007 to 2013. The terms Adolescent and Mental Health were used to search adequate articles as DeCs/MeSH bases. Results: Publications were found in different journals in different fields of knowledge and the quantitative research was the most frequent. The mental health issues were categorized as individual factors; drug related factors, school factors, family factors, social factors and STDs/Aids related factors. The most addressed category was individual factors, with 23 publications. Conclusion: The integrative review allowed to point important questions to be addressed in preventive actions by the health professional, including the nurse, to create a space that works with risk conditioning factors in adolescents for mental health aggravation.

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“…Third, our study had a limited number of HIV-infected adolescents, aged more than 11 years old, which may be the most vulnerable group to psychosocial issues and low QOL. Nachman et al 27 reported perinatally HIV-infected youth to have high rates of psychiatric symptoms, including depression. Children who had depression had poorer academic functional and overall QOL.…”

Section: Quality Of Life In Hiv-infected Childrenmentioning

confidence: 99%

“…Children who had depression had poorer academic functional and overall QOL. 27 Last, monthly income in our study was a self-report from the perception of caregivers. We did not collect the actual monthly income.…”

Section: Quality Of Life In Hiv-infected Childrenmentioning

confidence: 99%

Impact of Antiretroviral Therapy on Quality of Life in HIV-Infected Southeast Asian Children in the PREDICT Study

Bunupuradah

Kosalaraksa²,

Vibol³

et al. 2013

AIDS Patient Care and STDs

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Quality of life (QOL) is an important antiretroviral treatment (ART) outcome. We compared QOL among 299 Thai and Cambodian children ages 1-12 years-old, CD4 15-24% randomized to early (ART at week 0, N = 149) versus deferred groups (ART when at CD4 < 15%, N = 150) and also compared with QOL data from age-matched healthy controls (N = 275). Primary caregivers completed PACTG QOL questionnaires at week 0 and every 24 weeks until 144 weeks. Children were enrolled during March 2006 to September 2008. Mean (SD) age of children was 6.3 (2.8) years, 58% were female, 60% were Thai, %CDC N:A:B:C was 2:62:36:0%. During 144 weeks, all children in the early-group and 69 (46%) of deferred-group children started ART. There was no significant difference of QOL scores between treatment groups at baseline (all p > 0.05) and at week 144 (all p > 0.05). By multivariate analysis, the early-group had higher QOL score changes in five domains, including health perception ( p = 0.04), physical resilience ( p = 0.02), psychosocial well-being ( p = 0.04), social and role functioning ( p < 0.01), and symptoms ( p = 0.01) compared to the deferred group. QOL of HIV-infected children in both groups were lower than healthy control in all 7 domains at baseline (all p < 0.05) and 5 of 7 domains at weeks 144 ( p < 0.01). In conclusion, no significant difference of QOL scores between treatment groups. Early ART commencement associated with greater increase of QOL scores over 144 weeks. QOL scores in HIV-infected children were lower than healthy controls.

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Human Immunodeficiency Virus Disease Severity, Psychiatric Symptoms, and Functional Outcomes in Perinatally Infected Youth

Cited by 74 publications

References 18 publications

Executive Functioning in Children and Adolescents With Perinatal HIV Infection and Perinatal HIV Exposure

Executive Functioning in Children and Adolescents With Perinatal HIV Infection and Perinatal HIV Exposure

Risk factors associated with mental health issues in adolescents: a integrative review

Impact of Antiretroviral Therapy on Quality of Life in HIV-Infected Southeast Asian Children in the PREDICT Study

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