Human immunodeficiency virus type 1–serodiscordant couples can bear healthy children after undergoing intrauterine insemination

Marina, S.; Marina, Fernando; Alcolea, Ruth; Expósito, Rosabel; Huguet, Joan; Nadal, Javier; Vergés, Alfonso

doi:10.1016/s0015-0282(98)00102-2

Cited by 161 publications

(75 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No cases of horizontal HIV transmission were recorded after more than 4500 inseminations (Vernazza 2006). Similar experiences have been reported by others (Bujan 2004) (Marina 1998). Likewise, no seroconversion events have been recorded in women who have undergone IVF (Sauer 2002) or ICSI (Ohl 2003) in recent years.…”

Section: Description Of the Conditionsupporting

confidence: 81%

Sperm washing to prevent HIV transmission from HIV-infected men but allowing conception in serodiscordant couples

Eke¹,

Oragwu²

2010

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Section: Description Of the Conditionsupporting

confidence: 81%

Sperm washing to prevent HIV transmission from HIV-infected men but allowing conception in serodiscordant couples

Eke¹,

Oragwu²

2010

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

“…This problem is very acute because spermatozoa from HIV-positive men, cleared of seminal plasma and infected mononuclear cells, are used for medically assisted reproduction in serodiscordant couples (293)(294)(295). Thus, although semen washing on a density gradient before artificial insemination may reduce the risk of HIV transmission from the infected man to an uninfected woman (166,188), the virus may still be detected in the fraction of motile spermatozoa used for insemination (70,203,316). Insemination in such cases is, of course, not performed.…”

Section: Human Immunodeficiency Virus Typementioning

confidence: 99%

“…Insemination in such cases is, of course, not performed. These positive results may be false positives due to the use of a single set of primers in the PCR detection of HIV (203) or due to the presence of contaminating cells of nonseminal origin (the mean proportion of such cells is 1/1,000) (316). However, electron microscopy and immunocytochemistry studies have provided evidence that HIV-1 can attach to the surface of spermatozoa and enter these cells through the intact plasma membrane (24)(25)(26)).…”

Section: Human Immunodeficiency Virus Typementioning

confidence: 99%

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Dejucq

Jégou

2001

Microbiol Mol Biol Rev

290

220

View full text Add to dashboard Cite

This review describes the various viruses identified in the semen and reproductive tracts of mammals (including humans), their distribution in tissues and fluids, their possible cell targets, and the functional consequences of their infectivity on the reproductive and endocrine systems. The consequences of these viral infections on the reproductive tract and semen can be extremely serious in terms of organ integrity, development of pathological and cancerous processes, and transmission of diseases. Furthermore, of essential importance is the fact that viral infection of the testicular cells may result not only in changes in testicular function, a serious risk for the fertility and general health of the individual (such as a fall in testosteronemia leading to cachexia), but also in the possible transmission of virus-induced mutations to subsequent generations. In addition to providing an exhaustive account of the data available in these domains, this review focuses attention on the fact that the interface between endocrinology and virology has so far been poorly explored, particularly when major health, social and economical problems are posed. Our conclusions highlight the research strategies that need to be developed. Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system

show abstract

“…Treatments involve seropositive men and seronegative women undergoing either intrauterine insemination or in vitro fertilization (IVF). Marina et al [3], as early as 1998, reported on use of semen from men who were seropositive for human immunodeficiency virus type 1 (HIV-1) to inseminate their partners without infecting them. The men provided 107 semen samples that were prepared with the use of the Percoll and swim-up techniques.…”

Section: Introductionmentioning

confidence: 99%

“…The publication concluded that on the basis of the results, testing for HIV-1 with the use of the polymerase chain reaction technique on the semen fraction obtained after washing appears to prevent infection in the inseminated woman. This method makes it possible to help HIV-1-seropositive men to have children without infecting their female partners [3].…”

Section: Introductionmentioning

confidence: 99%

Yes, It is Possible

Allahbadia

2015

J Obstet Gynecol India

View full text Add to dashboard Cite

Human immunodeficiency virus-serodiscordant couples are actively seeking reproductive assistance and often consider or practice unsafe measures to achieve pregnancy. Reproductive issues and concerns unique to these couples need to be addressed before treatment.Assisted reproduction techniques can minimize the risk of infection and complete families associated with serodiscordant couples. Since 1987, more than 4000 published attempts have been reported in which processed spermatozoa from HIV-seropositive men were used to establish pregnancy in HIV-seronegative women. When the female partner is HIV positive, intrauterine insemination (IUI) will suffice in order to prevent horizontal infection. However, when the male partner is HIV positive, a technique developed in Milan over 15 years ago, involving sperm washing, is used in order to minimize infection of the healthy partner. Some couples need further treatment, due to inherent infertility, with advanced reproductive technology (ART) procedures, such as IVF or ICSI. Recent innovative approaches such as pre-exposure prophylaxis

show abstract

Human immunodeficiency virus type 1–serodiscordant couples can bear healthy children after undergoing intrauterine insemination

Cited by 161 publications

References 20 publications

Sperm washing to prevent HIV transmission from HIV-infected men but allowing conception in serodiscordant couples

Sperm washing to prevent HIV transmission from HIV-infected men but allowing conception in serodiscordant couples

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Yes, It is Possible

Contact Info

Product

Resources

About