Human-induced pluripotent stem cells as a source of hepatocyte-like cells: new kids on the block

Busletta, Chiara; Novo, Erica; Parola, Maurizio

doi:10.1007/s12072-011-9300-0

Cited by 5 publications

(1 citation statement)

References 59 publications

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“…As sharing most common features to human ESC, human iPSC are proved to be a suitable source to regenerate hepatocytes, and a variety of strategies have been developed in the past few years (Busletta et al, 2011;Chistiakov and Chistiakov, 2012). Song et al (2009) described the first successful hepatic differentiation of human iPSC, closely followed by several other reports (Liu et al, 2010;Rashid et al, 2010;Si-Tayeb et al, 2010b;Sullivan et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

Liu

Belmonte

2012

Protein Cell

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Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.

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