Human Intestinal Sarcosporidiosis: Report of Six Cases *

Bunyaratvej, S; Bunyawongwiroj, Praj; Nítiyanant, Prawat

doi:10.4269/ajtmh.1982.31.36

Cited by 47 publications

(16 citation statements)

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“…15 Clinically significant intestinal Sarcocystis infections in humans have rarely been reported, and include 6 cases of segmental enteritis, which is also associated with tissue eosinophilia. 16 Of the 52 reported cases, most were asymptomatic; however, 10 had symptoms, including fasiculations, myalgias, muscular weakness and wasting, subcutaneous nodules, and intermittent bronchospasm. In one patient, symptoms persisted for 7 years after diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…19 A growing body of evidence suggests that Sarcocystis muscle infection can be associated with significant disease. [1][2][3]5,[8][9][10][11][12][13][14][15][16] The high prevalence of muscle infection in indigenous Malaysian populations suggest that sarcocystosis is a common, seldom recognized infection in Malaysia. 11,15 As described above, other investigators have reported a spectrum of manifestations ranging from asymptomatic or acute, self-limited complaints to moderately severe, chronic illness.…”

Section: Discussionmentioning

confidence: 99%

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An outbreak of acute eosinophilic myositis attributed to human Sarcocystis parasitism.

Arness

Brown²,

Dubey³

et al. 1999

Am J Trop Med Hyg

107

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Abstract. Seven members of a 15-man U.S. military team that had operated in rural Malaysia developed an acute illness consisting of fever, myalgias, bronchospasm, fleeting pruritic rashes, transient lymphadenopathy, and subcutaneous nodules associated with eosinophilia, elevated erythrocyte sedimentation rate, and elevated levels of muscle creatinine kinase. Sarcocysts of an unidentified Sarcocystis species were found in skeletal muscle biopsies of the index case. Albendazole ameliorated symptoms in the index case; however, his symptoms persisted for more than 5 years. Symptoms in 5 other men were mild to moderate and self-limited, and 1 team member with laboratory abnormalities was asymptomatic. Of 8 team members tested for antibody to Sarcocystis, 6 were positive; of 4 with the eosinophilic myositis syndrome who were tested, all were positive. We attribute this outbreak of eosinophilic myositis to accidental tissue parasitism by Sarcocystis.Human muscular sarcocystosis (syn. sarcosporidiosis) is a rare infection caused by coccidian parasites in the family Sarcocystidae. More than 100 different species of Sarcocystis occur worldwide in a wide range of domestic and wild animal reservoirs, with reported prevalences varying between 10% and 100% in domestic livestock.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An outbreak of acute eosinophilic myositis attributed to human Sarcocystis parasitism.

Arness

Brown²,

Dubey³

et al. 1999

Am J Trop Med Hyg

107

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“…This is an exceedingly large number of sarcocysts and would rarely be found in naturally infected meat. Six persons in Thailand who reportedly ate spiced raw beef from zebu (but who possibly had eaten a variety of other animal products [unpublished data]) developed segmental necrotizing enteritis requiring surgical intervention (4). Histology of intestine samples from these patients revealed sexual stages attributed to Sarcocystis and gram-positive bacilli.…”

Section: Symptoms Human Definitive Hostsmentioning

confidence: 99%

Sarcocystis spp. in Human Infections

2004

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Sarcocystis species are intracellular protozoan parasites with an intermediate-definitive host life cycle based on a prey-predator relationship. Asexual stages develop in intermediate hosts after they ingest the oocyst stage from definitive-host feces and terminate with the formation of intramuscular cysts (sarcocysts). Sarcocysts in meat eaten by a definitive host initiate sexual stages in the intestine that terminate in oocysts excreted in the feces. Most Sarcocystis species infect specific hosts or closely related host species. For example, humans and some primates are definitive hosts for Sarcocystis hominis and S. suihominis after eating raw meat from cattle and pigs, respectively. The prevalence of intestinal sarcocystosis in humans is low and is only rarely associated with illness, except in volunteers who ingest large numbers of sarcocysts. Cases of infection of humans as intermediate hosts, with intramuscular cysts, number less than 100 and are of unknown origin. The asexual stages, including sarcocysts, can stimulate a strong inflammatory response. Livestock have suffered acute debilitating infections, resulting in abortion and death or chronic infections with failure to grow or thrive. This review provides a summary of Sarcocystis biology, including its morphology, life cycle, host specificity, prevalence, diagnosis, treatment, and prevention strategies, for human and food animal infections

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“…In Thailand, six patients 3 to 70 years of age with acute enteritis and leukocytosis underwent resection surgery of the ileum (48). The histopathological diagnosis indicated segmental eosinophilic enteritis or segmental necrotizing enteritis.…”

Section: Intestinal Sarcocystosis In Asiamentioning

confidence: 99%

Human Infections with Sarcocystis Species

2015

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SUMMARY Recurrent outbreaks of muscular sarcocystosis among tourists visiting islands in Malaysia have focused international attention on sarcocystosis, a disease once considered rare in humans. Sarcocystis species require two hosts, definitive and intermediate, to complete their life cycle. Humans can serve as definitive hosts, with intestinal sarcocystosis for two species acquired from eating undercooked meat: Sarcocystis hominis , from beef, and Sarcocystis suihominis , from pork. Symptoms such as nausea, stomachache, and diarrhea vary widely depending on the number of cysts ingested but appear more severe with pork than with beef. Humans serve as intermediate hosts for Sarcocystis nesbitti , a species with a reptilian definitive host, and possibly other unidentified species, acquired by ingesting sporocysts from feces-contaminated food or water and the environment; infections have an early phase of development in vascular endothelium, with illness that is difficult to diagnose; clinical signs include fever, headache, and myalgia. Subsequent development of intramuscular cysts is characterized by myositis. Presumptive diagnosis based on travel history to tropical regions, elevated serum enzyme levels, and eosinophilia is confirmed by finding sarcocysts in muscle biopsy specimens. There is no vaccine or confirmed effective antiparasitic drug for muscular sarcocystosis, but anti-inflammatory drugs may reduce symptoms. Prevention strategies are also discussed.

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Human Intestinal Sarcosporidiosis: Report of Six Cases *

Cited by 47 publications

References 0 publications

An outbreak of acute eosinophilic myositis attributed to human Sarcocystis parasitism.

An outbreak of acute eosinophilic myositis attributed to human Sarcocystis parasitism.

Sarcocystis spp. in Human Infections

Human Infections with Sarcocystis Species

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