Human iPSC-derived brain pericytes exhibit differences in inflammatory activation compared to primary human brain pericytes
Samuel JC McCullough,
Eliene Albers,
Akshata Anchan
et al.
Abstract:BackgroundiPSC-derived cells are increasingly used to model complex diseasesin vitrobecause they can be patient derived and can differentiate into any cell in the adult human body. Recent studies have demonstrated the generation of brain pericytes using a neural crest-based differentiation protocol. However, the inflammatory response of these iPSC-derived brain pericytes has not been investigated. We aimed to investigate the response of iPSC-derived brain pericytes to common inflammatory stimuli, thereby asses… Show more
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