Human Lateralization, Maternal Effects and Neurodevelopmental Disorders

Malatesta, Gianluca; Marzoli, Daniele; Prete, Giulia; Tommasi, Luca

doi:10.3389/fnbeh.2021.668520

Cited by 21 publications

(13 citation statements)

References 137 publications

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“…These findings are not only interesting from a basic neuroscience point of view, but also in the context of clinical neuroscience ( Malatesta et al, 2021 ; Mundorf and Ocklenburg, 2021 ). Indeed, several neurodevelopmental and psychiatric disorders such as dyslexia ( Woodhead et al, 2021 ), schizophrenia ( Ocklenburg et al, 2013 ), ASD ( Floris and Howells, 2018 ), and ADHD ( Alperin et al, 2019 ) have been linked to altered functional as well as structural hemispheric asymmetries ( Mundorf and Ocklenburg, 2021 ).…”

Section: Introductionmentioning

confidence: 83%

Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective

Mundorf

Peterburs

Ocklenburg

2021

Front. Syst. Neurosci.

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Recent large-scale neuroimaging studies suggest that most parts of the human brain show structural differences between the left and the right hemisphere. Such structural hemispheric asymmetries have been reported for both cortical and subcortical structures. Interestingly, many neurodevelopmental and psychiatric disorders have been associated with altered functional hemispheric asymmetries. However, findings concerning the relation between structural hemispheric asymmetries and disorders have largely been inconsistent, both within specific disorders as well as between disorders. In the present review, we compare structural asymmetries from a clinical neuroscience perspective across different disorders. We focus especially on recent large-scale neuroimaging studies, to concentrate on replicable effects. With the notable exception of major depressive disorder, all reviewed disorders were associated with distinct patterns of alterations in structural hemispheric asymmetries. While autism spectrum disorder was associated with altered structural hemispheric asymmetries in a broader range of brain areas, most other disorders were linked to more specific alterations in brain areas related to cognitive functions that have been associated with the symptomology of these disorders. The implications of these findings are highlighted in the context of transdiagnostic approaches to psychopathology.

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Section: Introductionmentioning

confidence: 83%

Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective

Mundorf

Peterburs

Ocklenburg

2021

Front. Syst. Neurosci.

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“…The frame connections of schizophrenia were concentrated in the left frontal lobe. Altered brain network asymmetry has been linked to development processes 32 and neuropsychiatric diseases, such as autism and schizophrenia 33 – 35 . The interhemispheric functional dysconnectivity in schizophrenia has been reported in many studies 36 – 38 .…”

Section: Discussionmentioning

confidence: 99%

Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia

Liu

et al. 2022

Schizophr

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It is widely accepted that there are some common network patterns in the human brain. However, the existence of stable and strong functional connections in the human brain and whether they change in schizophrenia is still a question. By setting 1% connections with the smallest coefficient of variation, we found a widespread brain functional network (frame network) in healthy people(n = 380, two datasets from public databases). We then explored the alterations in a medicated group (60 subjects with schizophrenia vs 71 matched controls) and a drug-naive first-episode group (68 subjects with schizophrenia vs 45 matched controls). A linear support vector classifier (SVC) was constructed to distinguish patients and controls using the medicated patients’ frame network. We found most frame connections of healthy people had high strength, which were symmetrical and connected the left and right hemispheres. Conversely, significant differences in frame connections were observed in both patient groups, which were positively correlated with negative symptoms (mainly language dysfunction). Additionally, patients’ frame network were more left-lateralized, concentrating on the left frontal lobe, and was quite accurate at distinguishing medicated patients from controls (classifier accuracy was 78.63%, sensitivity was 86.67%, specificity was 76.06%, and the area under the curve (AUC) was 0.83). Furthermore, the results were repeated in the drug-naive set (accuracy was 84.96%, sensitivity was 85.29%, specificity was 88.89%, and AUC was 0.93). These findings indicate that the abnormal pattern of frame network in subjects with schizophrenia might provide new insights into the dysconnectivity in schizophrenia.

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“…As extremely high sample sizes are needed to study the relationship between genes and behavior, we therefore propose to fill the gap in the literature by integrating especially behavioral measures of social laterality into test batteries for population-based genetic profiling such as the UK Biobank. Behavioral social laterality phenotypes can be easily acquired by asking participants to imagine, for example, to cradle a child, which has been demonstrated to reliably produce the universally found left-sided cradling bias (Malatesta et al, 2021b ; Vauclair, 2022 ) or imagine to which side they turn their heads during a kiss. Such methods are highly economical as they can be included in survey questionnaires.…”

Section: Integrating Social Laterality: a Research Proposalmentioning

confidence: 99%