Human leucocyte antigen (HLA)-A, -B, -C, -DRB1 and -DQB1 haplotype frequencies from 2491 cord blood units from Tamil speaking population from Tamil Nadu, India

Narayan, Saranya; Maiers, Martin; Halagan, Mike; Sathishkannan, Arunadevi; Naganathan, Chandramouleeswaran; Madbouly, Abeer; Periathiruvadi, Srinivasan

doi:10.1007/s11033-018-4382-6

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…The mother tongue or one's native language is therefore used as a marker against the donors' sample, making a language-specific registry possible (see Figure 3 ). A 2018 study with data obtained from donated cord blood units at Jeevan identifies certain inherited haplotypes (set of genetic determinants inherited from both parents) 13 frequencies in the Tamil-speaking population (Narayan, 2018 ). A recent study proposes a link between South Indian language groups (Malayalam, Urdu, Kannada, Telugu, and Tamil) and finding donors for patients based in Sri Lanka (Seshasubramanian et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

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Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Panwar¹

2023

Front. Sociol.

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Thalassemia and leukemia and related blood disorders are approved for blood stem cell transplants in India, for a stem cell transplant to be successful, the human leukocyte antigen (HLA) complex located on the arm of chromosome six must be a match between the cord blood donor and the recipient. In the quest to find an exact blood stem cell match for an individual, the HLA becomes the node at the center of community genetics where the HLA match is sought (not necessarily successful) in the extended family, the same caste, language, and ethnic (both national and the diaspora) groups. By considering thalassemia as a case study, how do we understand personalized stem cell therapies within biobanking infrastructures in Chennai? How do social categories get entwined with biological materials like cord blood?

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Section: Methodsmentioning

confidence: 99%

“… 10 Referring to Narayan, 2018 , human leukocyte antigen (HLA)-A, -B, -C, -DRB1, and -DQB1 haplotype frequencies from 2,491 cord blood units from Tamil-speaking population from Tamil Nadu, India. …”

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confidence: 99%

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Panwar¹

2023

Front. Sociol.

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“…HLA data are available in the Allele Frequencies Net Database (http://www.allelefrequencies.net) under the population names India Kerala Malayalam Speaking (pop_id=3620 in AFND); India Andhra Pradesh Telugu Speaking (pop_id = 3434 in AFND); India Karnataka Kannada Speaking (pop_id = 3622 in AFND); India Tamilnadu 3‐7 . HLA data for Urdu speaking population is published 4 .…”

Section: Resultsmentioning

confidence: 99%

Molecular analysis of HLA Class I and Class II genes in five different South Indian linguistic groups

Seshasubramanian¹,

SathishKannan²,

Naganathan³

et al. 2021

HLA

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South Indians are a heterogeneous population who speak different languages and differ in their life style and physical appearance. Major population movements, social structure and caste endogamy have influenced the genetic structure of Indian populations. The human leukocyte antigen (HLA) system of populations is highly informative because of the high level of polymorphisms. Knowledge of allele and haplotype frequencies of the HLA system is important in the search for unrelated bone marrow donors. We investigated the distribution of HLA A, B, C, DRB1 and DQB1 loci in five linguistic groups from South India. HLA–A*01:01:01~B*57:01:01:01~C*06:02:01~DRB1*07:01:01~DQB1*03:03:02 was the common haplotype with highest frequency in all the five populations studied. A few relevant haplotypes were identified as most common haplotypes in each linguistic group. Comparison of HLA‐A, ‐B and ‐DRB1 allele distribution in these five linguistic groups with the other Asian population showed that the South Indian populations were closely related to Sri Lankan populations. A large South Indian donor registry might serve as good source of donors for patients from Sri Lanka and vice versa.

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“…The next common alleles reported in South Indians were the split antigens of the HLA B5 serotype, HLA B* 51 ( 8–12.5%) and HLA B* 52 (5–10%). Their association with different vasculitides was reported (HLA B*51 and Behchet’sdiseases, HLA B* 52, and Takayasu’s arteritis) [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Association of HLA-B51:01, HLA-B55:01, CYP2C9*3, and Phenytoin-Induced Cutaneous Adverse Drug Reactions in the South Indian Tamil Population

John

Balakrishnan

Sukasem

et al. 2021

JPM

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Phenytoin (PHT) is one of the most commonly reported aromatic anti-epileptic drugs (AEDs) to cause cutaneous adverse reactions (CADRs), particularly severe cutaneous adverse reactions (SCARs). Although human leukocyte antigen (HLA)-B*15:02 is associated with PHT-induced Steven Johnson syndrome/toxic epidermal necrosis (SJS/TEN) in East Asians, the association is much weaker than it is reported for carbamazepine (CBZ). In this study, we investigated the association of pharmacogenetic variants of the HLA B gene and CYP2C9*3 with PHT-CADRs in South Indian epileptic patients. This prospective case-controlled study included 25 PHT-induced CADRs, 30 phenytoin-tolerant patients, and 463 (HLA-B) and 82 (CYP2C9*3) normal-controls from previous studies included for the case and normal-control comparison. Six SCARs cases and 19 mild-moderate reactions were observed among the 25 cases. Pooled data analysis was performed for the HLA B*51:01 and PHT-CADRs associations. The Fisher exact test and multivariate binary logistic regression analysis were used to identify the susceptible alleles associated with PHT-CADRs. Multivariate analysis showed that CYP2C9*3 was significantly associated with overall PHT-CADRs (OR = 12.00, 95% CI 2.759–84.87, p = 003). In subgroup analysis, CYP2C9*3 and HLA B*55:01 were found to be associated with PHT-SCARs (OR = 12.45, 95% CI 1.138–136.2, p = 0.003) and PHT-maculopapular exanthema (MPE) (OR = 4.041, 95% CI 1.125–15.67, p = 0.035), respectively. Pooled data analysis has confirmed the association between HLA B*51:01/PHT-SCARs (OR = 6.273, 95% CI 2.24–16.69, p = <0.001) and HLA B*51:01/PHT-overall CADRs (OR = 2.323, 95% CI 1.22–5.899, p = 0.037). In this study, neither the case nor the control groups had any patients with HLA B*15:02. The risk variables for PHT-SCARs, PHT-overall CADRs, and PHT-MPE were found to be HLA B*51:01, CYP2C9*3, and HLA B*55:01, respectively. These alleles were identified as the risk factors for the first time in the South Indian Tamil population for PHT-CADRs. Further investigation is warranted to establish the clinical relevance of these alleles in this population with larger sample size.

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Human leucocyte antigen (HLA)-A, -B, -C, -DRB1 and -DQB1 haplotype frequencies from 2491 cord blood units from Tamil speaking population from Tamil Nadu, India

Cited by 7 publications

References 12 publications

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Molecular analysis of HLA Class I and Class II genes in five different South Indian linguistic groups

Association of HLA-B51:01, HLA-B55:01, CYP2C9*3, and Phenytoin-Induced Cutaneous Adverse Drug Reactions in the South Indian Tamil Population

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Human leucocyte antigen (HLA)-A, -B, -C, -DRB1 and -DQB1 haplotype frequencies from 2491 cord blood units from Tamil speaking population from Tamil Nadu, India

Cited by 7 publications

References 12 publications

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Molecular analysis of HLA Class I and Class II genes in five different South Indian linguistic groups

Association of HLA-B*51:01, HLA-B*55:01, CYP2C9*3, and Phenytoin-Induced Cutaneous Adverse Drug Reactions in the South Indian Tamil Population

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Association of HLA-B51:01, HLA-B55:01, CYP2C9*3, and Phenytoin-Induced Cutaneous Adverse Drug Reactions in the South Indian Tamil Population