Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: A meta-analysis

Xin, Hong; Yu, Renbo; Sun, Ninghui; Wang, Bin; Xu, Yaochu; Wu, Guan-Ling

doi:10.3748/wjg.v11.i46.7302

Cited by 78 publications

(70 citation statements)

References 54 publications

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“…This leads to increased resistance to chronic HCV infection in patients who possess them. 8 Moreover, interleukin-10 haplotypes are possible predictors of spontaneous clearance of HCV infection. 9 Here we report 2 HIV-HCV-coinfected patients who experienced spontaneous resolution of chronic HCV infection following OLT in the absence of anti-HCV treatment.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

Bhagat¹,

Foont²,

Schiff³

et al. 2007

Liver Transpl

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Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV-coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear. Liver Transpl 14:92-95, 2008.

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Section: Discussionmentioning

confidence: 99%

Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

Bhagat¹,

Foont²,

Schiff³

et al. 2007

Liver Transpl

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“…HLA-DR13 is associated with HBV clearance (22). HLA-DRB1*1101 and DQB1*0301 alleles are related with reduced risk of developing chronic HCV infection (23). The relation of HLA alleles with autoimmune hepatitis, sclerosing cholangitis and primary biliary cirrhosis have been researched in the literature, and associations differ with ethnicity and geographical location (24).…”

Section: Discussionmentioning

confidence: 99%

A new risk factor for the development of non-alcoholic fatty liver disease: HLA complex genes

Celıkbılek

Şelçuk²,

Yilmaz³

2011

Turk J Gastroenterol

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(33 erkek, ortalama yafl: 53,8 [yafl aral›¤›, 32-77]) ve ultrasonografisi normal 50 verici aday› kontrol grubu olarak al›nd› (20 erkek, ortalama yafl: 44,6 [yafl aral›¤›, 26-71] (33 male, median age: 53.8 [range, 32-77 years]) by means of ultrasonography data, and 50 individuals, whose ultrasonography data did not show hepatosteatosis, comprised the control group (20 male, median age: 44.6 [range, 26-71 years]

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“…In two independent metaanalyses, the association between DRB1*1101 and viral clearance had an OR of 2.5 (95% CI 1.7-3.7) and 2.02 (95% CI 1.6-2.6), respectively, whereas the association between DQB1*03 and viral clearance was estimated at an OR of 3.0 (95% CI 1.8-4.8) and 2.4 (95% CI 1.6-3.4), respectively. 95,96 Notably, different factors may have contributed to an overinterpretation of the protective role of DRB1*11 and DQB1*0301 in both metaanalyses. First, there might be a bias towards the publication of studies with positive HLA associations, whereas studies showing no significant association with any HLA allele are probably less likely published.…”

Section: Role Of Class II Alleles In Hcv Infectionmentioning

confidence: 99%

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

Thimme

2007

Genes Immun

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The immunobiology of hepatitis C virus (HCV) is significantly influenced by the host immune response to the virus, especially by virus-specific T-cell responses. Virus-specific T cells are restricted by human leucocyte antigen class I and II molecules. Of note, associations between these polymorphic loci and outcome and course of HCV infection have been reported in large and well-documented cohorts. This review will briefly summarize these studies and focus especially on the immunological and virological basis for the reported associations. The outcome and course of HCV infection is most likely determined by a complex interplay of genetic, immunological and virological factors. A better understanding of these host-virus interactions is essential not only to gain better insights into the mechanisms of viral clearance and persistence but also for the development of new antiviral vaccine strategies.

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Human leukocyte antigen class II DQB10301, DRB11101 alleles and spontaneous clearance of hepatitis C virus infection: A meta-analysis

Cited by 78 publications

References 54 publications

Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

A new risk factor for the development of non-alcoholic fatty liver disease: HLA complex genes

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

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