Human Leukocyte Antigen Class II Alleles and Risk of Cervical Cancer in China

Wu, Yuping; Liu, Benrong; Lin, Wenzhi; Xu, Yunping; Li, Longyu; Zhang, Yanling; Chen, Shangwu; Lin, Zhongqiu; Xu, Anlong

doi:10.1016/j.humimm.2006.07.005

Cited by 29 publications

(20 citation statements)

References 38 publications

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“…As for the HLA-DRB1 alleles, DRB1*13:02:01 was found with lower frequency among the SCC patients (P = 0.04, OR = 0). This is consistent with a previous report in Chinese women (Wu et al, 2007), where DRB1*13:02:01 were also found to be nominally protective of cervical cancer (P = 0.013, OR = 0.110, P c = 0.39). Moreover, DRB1*13:02:01 has also been found to be with lower frequency among French (Sastre-Garau et al, 1996), Brazilian (Maciag et al, 2000) and other populations (Hildesheim et al, 1998;Beskow et al, 2001) with cervical cancer when compared with controls.…”

Section: Discussionsupporting

confidence: 93%

HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

Xiao¹,

Liu²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 93%

HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

Xiao¹,

Liu²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…However, the HLA-DPB1 locus was seldom studied because of its few polymorphisms and low cell surface expression levels [27]. A significant increase in DPB1*13:01 allele in cervical cancer patients and a significant decrease in DPB1*04:01:01 allele in HPV-16 positive cervical cancer patients were previously reported in a central Chinese population [10]. Another study in southern Chinese women demonstrated an increased risk of cervical cancer with both HLA-DPB1*02:02 and *13:01 alleles [11].…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have shown that HLA-A*03:01, *11:04, B*44:02, and Cw*05:01 alleles conferred susceptibility to cervical cancer, but a protective effect against the disease was found in HLA-A*24:02, B*15:01, and Cw*02:02 alleles [6][7][8]. However, only a few studies have explored the association between HLA-DPB1 and cervical cancer [9][10][11] and no such data on Taiwanese population have been reported.…”

Section: Introductionmentioning

confidence: 99%

Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women

Yang

Chang

Chen

et al. 2015

Cancer Immunol Immunother

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Cervical cancer is a multifactorial disease, and increasing evidence suggests that host immunogenetic background may contribute to its pathogenesis. Genetic variations in human leukocyte antigen (HLA) genes may alter the efficiency of immune response to human papillomavirus (HPV) antigens and have been implicated in the risk of cervical cancer. We investigated whether polymorphisms in the HLA-DPB1 gene were associated with cervical cancer risk in a Taiwanese population. HLA-DPB1 alleles and +550 G/A polymorphism were genotyped in a case-control study of 473 women with cervical squamous cell carcinoma (CSCC) and 676 healthy controls. The presence and genotypes of HPV in CSCC were determined. We found that the DPB1*05:01 and +550 A alleles were associated with decreased and increased risk of CSCC, respectively [odds ratio (OR) = 0.72, Pc = 0.001; OR = 1.25, Pc = 0.03]. In subgroup analysis based on HPV type 16 positivity, significant associations were shown in the DPB1*05:01 and *13:01 alleles (OR = 0.65, Pc = 0.0007; OR = 1.83, Pc = 0.004). Furthermore, the DPB1*05:01-G and *13:01-G haplotypes conferred decreased and increased risk of both CSCC and HPV-16 positive CSCC women, respectively (OR = 0.72, Pc = 0.0009; OR = 0.63, Pc = 0.0004 for DPB1*05:01-G; OR = 1.55, Pc = 0.03; OR = 1.84, Pc = 0.004 for DPB1*13:01-G). A risk haplotype DPB1*02:01-A was also observed in the HPV-16 positive CSCC women (OR = 1.51, Pc = 0.05). These findings suggest that HLA-DPB1 gene is involved in the CSCC development.

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“…Because of its important role in the immune response and high polymorphism, the HLA system is associated with many diseases. Recently, many papers about the association between HLA and many types of tumor have been published, including cervical cancer (Schiff et al, 2005;Madeleine et al, 2008), leukemia (Dorak et al, 2002;Mundhada et al, 2004;Wu et al, 2007;Yari et al, 2008), gastric cancer (Wu et al, 2002;Quintero et al, 2005), ovarian cancer (Kübler et al, 2006), thyroid cancer (Haghpanah et al, 2009), and breast cancer (Cantú de León et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

Yang¹,

Wang²,

Shi³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. The primary function of the human leukocyte antigen (HLA) system is to regulate the immune response. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-A, B and DRB1 alleles in 100 unrelated patients with lung carcinoma and in 438 unrelated normal controls of Han nationality from North China, using sequencebased typing and PCR with sequence-specific primers. We found that the frequencies of HLA-A*0201, A*2601, B*1518, B*3802, DRB1*0401, DRB1*0402, and DRB1*1201 were higher in the lung carcinoma group than in the normal control group. The P values were 0.035, 0.040, 0.001, 0.017, 0.014, 0.004, and 0.019, respectively, and the odds ratio values were 1. 052, 3.513, 4.047, 3.054, 4.237, 19.397, and 2.128, respectively. The frequency of HLA-DRB1*1302 was lower in the lung carcinoma group than in the normal control group (P = 0.046, odds ratio = 0.168). We concluded that patients with lung

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Human Leukocyte Antigen Class II Alleles and Risk of Cervical Cancer in China

Cited by 29 publications

References 38 publications

HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

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