Human Leukocyte Antigen Distribution in German Caucasians with Advanced Ewing’s Sarcoma

Abstract

We report an increased incidence of circumscribed HLA patterns in German Caucasians with advanced ESFT. The possible clinical significance of this observation has to be re-assessed in prospective trials comprising larger ESFT patient numbers of all risk groups.

Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity

“…We choose HLA-A Ã 02:01 due to its dominant expression in the Caucasian population (around 50%) and similar prevalence in ES patients. 45 The STEAP1 130 peptide (YLPGVIAAI) was not only well recognized by allo-restricted T cells but similarly seemed processed and presented on HLA-A Ã 02:01, based on HLA-A Ã 02:01 and STEAP1 cDNA co-transfection experiments into Cos-7 cells.…”