Human longevity: Genetics or Lifestyle? It takes two to tango

Passarino, Giuseppe; Rango, Francesco De; Montesanto, Alberto

doi:10.1186/s12979-016-0066-z

Cited by 145 publications

(101 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the others can attain a similar result by targeting the same pathways with appropriate life style or interventions. 32 In eastern cultures, elders and their practical wisdom are respected. Their life style is a mixture of hereditary influence of eastern culture, familial and spiritual beliefs, restricted dietary habits, socializing patterns, physical and mental exercise.…”

Section: Discussionmentioning

confidence: 99%

Centenarians in India: the present scenario

Bhattacharyya¹

2017

Int J Community Med Public Health

View full text Add to dashboard Cite

India, officially the Republic of India is a country in South Asia. It is the seventh-largest country by area, the second-most populous country (with over 1.2 billion people), and the most populous democracy in the world. A country of myriad subcultures which constitutes a unique phenomenon of ‘unity in diversity’. India is the home of people of various ethnicity, religion, culture and languages. It has its own primitive cultures. Later, in different times this country was attacked by Greek, Shak, Hun, Pathan, Mughal, British, Dutch, French etc. So there is a diverse collection of culture and ethnicity, rather a conglomeration of these. The number of 100-year-olds in India has steadily increased over the last few decades. Keeping the above background in mind, the present scenario—the prospects, expectations and problems faced by a large number of centenarians scattered in different regions of this country, has discussed in this review.

show abstract

Section: Discussionmentioning

confidence: 99%

Centenarians in India: the present scenario

Bhattacharyya¹

2017

Int J Community Med Public Health

View full text Add to dashboard Cite

show abstract

“…Nevertheless, ageing as a process remains complex, as it encompasses a variety of factors . These factors include elements that affect lifespan, cellular changes and longevity . Because of the role of SIRT6 in longevity, it may be viewed as a potential connection between ageing and cancer.…”

Section: Sirt6 Connection Between Ageing and Cancermentioning

confidence: 99%

The sirtuin 6: An overture in skin cancer

Garcia-Peterson

Guzmán-Pérez

Krier

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

In the recent past, the sirtuins have been under intense investigation for their roles in biology and disease, including cancer. The sirtuin SIRT6 is comparatively a lesser studied member of this family of seven proteins. Like certain other sirtuins, SIRT6 is emerging to have an oncogenic function as well as tumor suppressor roles in cancer. Limited studies have been conducted assessing the role and functional significance of SIRT6 in melanoma and non-melanoma skin cancers. In this review, we have attempted to critically dissect the potential role and significance of SIRT6 in skin carcinogenesis. With limited available information to date, SIRT6 appears to have a pro-proliferative function in non-melanoma skin cancers (NMSCs), including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). In addition, SIRT6 is also emerging to have an oncogenic function in melanoma. Moreover, we have provided information regarding the available SIRT6 inhibitors. Conclusively, it appears that additional comprehensive studies are needed to establish the role of SIRT6 in skin biology and skin diseases, including cancer. Further, concerted efforts are needed to characterize the stage-specific role of SIRT6 in skin cancers. K E Y W O R D Smelanoma, SIRT6, skin, skin cancer | 125

show abstract

“…Major implementations in lifestylestyle changes have been conducted and to introduce calorie restriction that alters cell metabolism by the use of specific nutrients to improve immunity connected to longevity (3). Genes that determine premature lifespan in humans have been identified and include genes (3,4) such as breast cancer genes BRCA1 and BRCA2 and hyperlipidemia genes (the low-density lipoprotein receptor, apolipoprotein B).…”

Section: Editorialmentioning

confidence: 99%

Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals

2018

IJOAR

View full text Add to dashboard Cite

The process of aging is determined by various genetic and environmental factors. Aging is associated with increased oxidative stress that alters cellular chromatin structure, DNA methylation with histone modifications. These epigenetic alterations lead to nuclear changes associated with mitochondrial apoptosis that is a major defect in the global chronic disease epidemic (1). The variability in longevity between individuals in different communities implicate various nutritional and environmental factors involved in transcriptional dysregulation that lead to cell damage that accumulates with age and contributes to mitophagy, insulin resistance and programmed cell death. The absence or malfunction of a gene (2) necessary for transcriptional regulation of gene expression, DNA repair and telomere maintenance in neurons has become essential with relevance to neurodegeneration that determines aging and lifespan.

show abstract

Human longevity: Genetics or Lifestyle? It takes two to tango

Cited by 145 publications

References 59 publications

Centenarians in India: the present scenario

Centenarians in India: the present scenario

The sirtuin 6: An overture in skin cancer

Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals

Contact Info

Product

Resources

About