Human mesenchymal stem cells improve the neurodegeneration of femoral nerve in a diabetic foot ulceration rats

Xia, Nan; Xu, Jin; Zhao, Nan; Zhao, Qingsong; Li, Ming; Zhang, Cheng

doi:10.1016/j.neulet.2015.04.038

Cited by 22 publications

(19 citation statements)

References 29 publications

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“…Animal studies have indicated the ability of human UCB-MSCs to prevent or cure DFU via angiogenesis and the expression of nerve growth factor (NGF) in femoral nerve innervated gastrocnemius of diabetic foot ulceration rats [70]. In vitro, human UCB-MSCs might have capacity for diabetic wound healing by producing VEGF and basic fibroblast growth factor (bFGF) [71].…”

Section: Umbilical Cord Blood-derived Mesenchymal Stem Cells (Ucb-mentioning

confidence: 99%

Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer

Cao

Gang

Wang

2017

Journal of Diabetes Research

141

119

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Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation.

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Section: Umbilical Cord Blood-derived Mesenchymal Stem Cells (Ucb-mentioning

confidence: 99%

Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer

Cao

Gang

Wang

2017

Journal of Diabetes Research

141

119

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“…MSCs could partially repair the function of neurons. Xia et al [ 74 ] indicated that hMSCs-UC treatment partially reverses neuronal degeneration and femoral nerve function in rats with diabetic foot ulceration, which might be due to upregulated nerve growth factor and dramatic angiogenesis in FN-innervated gastrocnemius, consequently reversing neuronal structure and function, preventing or curing foot ulceration. MSCs could facilitate wound healing in diabetic mice by improving keratinocyte cell function.…”

Section: Advances In the Treatment Of Diabetic Foot Ulceration By mentioning

confidence: 99%

Advances in the Treatment of Ischemic Diseases by Mesenchymal Stem Cells

Wang

et al. 2016

Stem Cells International

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Ischemic diseases are a group of diseases, including ischemic cerebrovascular disease, ischemic cardiomyopathy (ICM), and diabetic foot as well as other diseases which are becoming a leading cause of morbidity and mortality in the whole world. Mesenchymal stem cells (MSCs) have been used to treat a variety of ischemic diseases in animal models and clinical trials. Lots of recent publications demonstrated that MSCs therapy was safe and relieved symptoms in patients of ischemic disease. However, many factors could influence therapeutic efficacy including route of delivery, MSCs' survival and residential rate in vivo, timing of transplantation, particular microenvironment, and patient's clinical condition. In this review, the current status, therapeutic potential, and the detailed factors of MSCs-based therapeutics for ischemic cerebrovascular disease, ICM, and diabetic foot are presented and discussed. We think that MSCs transplantation would constitute an ideal option for patients with ischemic diseases.

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“…In terms of key benefits, the femoral nerve model seems to offer another advantage, which is the missing of feared complications such as autotomy, contractures of the limb or skin ulcerations, but it has yet to be proven that these do never occur or just far less frequent than in the sciatic nerve model (Irintchev, ). In the last years, studies of peripheral nerve repair and regeneration in the rat femoral nerve model increased considerably (Adel et al, ; Hong, Hong, Gu, Lin, & Yin, ; Irintchev, Guntinas‐Lichius, & Irintchev, ; Meng et al, ; Xia et al, ). In contrast to the sciatic nerve model, no satisfactory method had been published to perform functional analysis in the femoral nerve model until 2005 (Irintchev, Simova, Eberhardt, Morellini, & Schachner, ).…”

Section: Introductionmentioning

confidence: 99%

The course of recovery of locomotor function over a 10‐week observation period in a rat model of femoral nerve resection and autograft repair

2020

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Background:A great extent of knowledge on peripheral nerve regeneration has been gathered using the rat sciatic nerve model. The femoral nerve model of the rat offers an interesting alternative, as it lacks disadvantageous features such as automutilation. For the analysis of locomotor behavior in rats after sciatic nerve injury, the CatWalk ™ XT Gait Analysis System is often used. However, lesions of the femoral nerve in the rat have yet remained unstudied with this method. Material and Methods: Ten male Sprague Dawley rats were evaluated with theCatWalk XT to study their gait after a 6-mm resection of the right femoral nerve and reconstruction with an autologous nerve graft. Animals were observed for 10 weeks after surgery.Results: Print Area, Print Length, Swing Speed, and Duty Cycle decreased to a minimum of 40% of baseline 2 weeks after surgery. Swing Time was elevated more than twofold at this time point. However, all these parameters recovered back to >90% of baseline values at 10 weeks after surgery. This degree of functional recovery has not been reported after sciatic nerve resection and autograft repair. Base of support varied minimally postoperatively in contrast to a strong decrement after sciatic nerve resection and repair. Conclusion:We hereby provide a comprehensive in-depth analysis of how to study functional recovery after injury of the femoral nerve in the rat via the CatWalk XT.We place special emphasis on highlighting the differences between the femoral nerve and sciatic nerve injury model in this context. K E Y W O R D SCatWalk XT, femoral nerve, functional recovery, gait analysis, rats, sciatic nerve

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Human mesenchymal stem cells improve the neurodegeneration of femoral nerve in a diabetic foot ulceration rats

Cited by 22 publications

References 29 publications

Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer

Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer

Advances in the Treatment of Ischemic Diseases by Mesenchymal Stem Cells

The course of recovery of locomotor function over a 10‐week observation period in a rat model of femoral nerve resection and autograft repair

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