“…However, inhaled anesthetics (14, 15) and hypotensive agents (16–18) can affect the autoregulation of CBF. The addition of CH to ANH has been reported to impair the augmentation of CBF induced by hemodilution (17–19). Crystal et al (17) showed that the increased CBF during hemodilution decreased again on CH, resulting in cerebral tissue oxygen metabolism imbalance, in dogs.…”