Human odontoblast cell numbers after dental injury

Murray, Peter E.; About, Imad; Lumley, P. J.; Franquin, Jean‐Claude; Remusat, M; Smith, Anthony J.

doi:10.1016/s0300-5712(99)00078-0

Cited by 66 publications

(65 citation statements)

References 60 publications

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“…In 1991, Pameijer, Stanley, and Ecker reported that an RDT of 1 mm would better protect the pulp tissue from the cytotoxic effects of zinc phosphate and resin-modified glass ionomer materials during the luting process 17) . In 2000, it was suggested that these were cautious estimates and that excessive tooth preparations, carefully cut down to 0.50 mm, appeared to have only a limited effect on the underlying odontoblast survival 2,5,7) . It was reported that specimens that had dentin thicknesses of 0.30-0.40 mm could yield Z 2 OCT images 18) .…”

Section: The Importance Of Rdt For Preventing Pulpal Injurymentioning

confidence: 99%

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Measurement of the remaining dentin thickness using optical coherence tomography for crown preparation

et al. 2014

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This study aimed to investigate the maximum depth imaging and optical properties of the dentin near the pulp by using optical coherence tomography (OCT) and to explore the possibility of measuring the remaining dentin thickness (RDT). Human third molars were used. In experiment 1, the cuspal dentin blocks (0.50-mm to 1.75-mm thickness) were prepared. Each specimen was scanned using OCT. OCT images could be obtained for all specimens with 1.00-mm or less thicknesses. In experiment 2, dentin-pulp complex slices (0.50-mm and 1.00-mm RDT) were prepared. Each specimen was scanned using OCT and micro-computed tomography, and compared. The resulting length change rates of OCT images for the 0.50-mm RDTs were significantly lower than those of the 1.00-mm RDTs. Within the limitations of this study, OCT was effective for measuring the 1.00-mm or less RDT and preventing pulpal injury, while considering the length change rate of OCT image as a variable.

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Section: The Importance Of Rdt For Preventing Pulpal Injurymentioning

confidence: 99%

“…Dentin is the most effective protective barrier to reduce pulpal injury, for example, pulpal inflammation and exposure. The concept of the dentin-pulp complex is well founded and generally recognized [3][4][5][6] . Injury to the pulp may become more intense as a result of tooth preparation.…”

Section: Introductionmentioning

confidence: 99%

Measurement of the remaining dentin thickness using optical coherence tomography for crown preparation

et al. 2014

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“…The preservation of pulp vitality following restorative intervention is dependent on the degree to which the pulpal cell populations can survive, as well as the ability of these cells to detect and respond to injury to initiate an appropriate repair response (Murray et al, 2000b). The most visible repair response to pulp injury is the deposition of a tertiary dentin matrix.…”

Section: (A) Importance Of Preserving Pulp Vitalitymentioning

confidence: 99%

Analysis of Pulpal Reactions to Restorative Procedures, Materials, Pulp Capping, and Future Therapies

Murray

Windsor

Smyth

et al. 2002

Critical Reviews in Oral Biology & Medicine

133

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Every year, despite the effectiveness of preventive dentistry and dental health care, 290 million fillings are placed each year in the United States; two-thirds of these involve the replacement of failed restorations. Improvements in the success of restorative treatments may be possible if caries management strategies, selection of restorative materials, and their proper use to avoid post-operative complications were investigated from a biological perspective. Consequently, this review will examine pulp injury and healing reactions to different restorative variables. The application of tissue engineering approaches to restorative dentistry will require the transplantation, replacement, or regeneration of cells, and/or stimulation of mineralized tissue formation. This might solve major dental problems, by remineralizing caries lesions, vaccinating against caries and oral diseases, and restoring injured or replacing lost teeth. However, until these therapies can be introduced clinically, the avoidance of post-operative complications with conventional therapies requires attention to numerous aspects of treatment highlighted in this review.

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“…However, maximizing the RDT could have a beneficial effect to limit pulp tissue destruction with buffering properties of dentine which could modify the possible cytotoxic properties of dental materials. 21 In very deep cavities, RDT between 0.25 to 0.01 mm or in pulp exposure cavities, dental pulp stem cells proliferate, migrate to the site of injury and differentiate to form odontoblastoid cells. These odontoblastoid cells replace the severely damaged odontoblasts that have been reduced 100% and secrete reparative dentine, which is considered to be the most visible repair response to pulp injury.…”

Section: Discussionmentioning

confidence: 99%

Proliferative activity of cells from remaining dental pulp in response to treatment with dental materials

Lutfi

Kannan

Fazliah

et al. 2010

Australian Dental Journal

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Background: The biological examination of pulp injury, repair events and response of dental pulp stem cells to dental restorative materials is important to accomplish restorative treatment, especially to commonly used dental materials in paediatric dentistry, such as glass ionomer cement (GIC) and calcium hydroxide (Ca(OH) 2 ) lining cement. Methods: Healthy patients aged between 9 to 11 years with carious primary molars without pulp exposure were selected and divided into two groups: Group 1 (teeth restored with GIC) and Group 2 (teeth lined using Ca(OH) 2 and restored with GIC). The proliferative activity of stem cells of teeth between these two groups was compared using colourimetric cell proliferation reagent, alamarBlue. Immunocytochemistry and flow cytometry confirmation were performed using mesenchymal stem cell markers, CD105 and CD166. Results: The proliferative activity using alamarBlue TM assay showed that cells derived from the remaining dental pulp of exfoliated deciduous teeth were positive for CD105 and CD166 and exhibited no difference between the two groups. Conclusions: It can be concluded that the use of Ca(OH) 2 or GIC as a lining material in indirect pulp capping procedures has the same effect on cells derived from the remaining dental pulp of exfoliated deciduous teeth which have responded favourably to the restorative treatments.

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Human odontoblast cell numbers after dental injury

Cited by 66 publications

References 60 publications

Measurement of the remaining dentin thickness using optical coherence tomography for crown preparation

Measurement of the remaining dentin thickness using optical coherence tomography for crown preparation

Analysis of Pulpal Reactions to Restorative Procedures, Materials, Pulp Capping, and Future Therapies

Proliferative activity of cells from remaining dental pulp in response to treatment with dental materials

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