Human papilloma virus: global research architecture assessed by density-equalizing mapping

Abstract

Human papilloma virus (HPV) infection is linked to cervical cancer, which represents the world's fourth most common cancer in women. So far, no detailed map of the worldwide HPV research architecture has been constructed. Hence, this study focuses on the chronological development and geographical distribution of the global HPV-specific publications and evaluates citation-based parameters as well as socioeconomic features of the publishing countries.In total, 29,330 HPV-related publications were identified. The US was the leading country with 12,270 publications. Only high-income-countries were found in the ranking of the fifteen most active countries with Germany, France, and Japan among the top five. Analysis of HPV research activity in relation to the economic strength demonstrated a lead position of Finland and Sweden with an average of 2248.78 and 1924.67 HPV-related publications per GDP in 1000 bn US-$, respectively. The most active upper-middle-income country was Mexico (416.78 HPV-related publications per GDP in 1000 bn US-$). India as lower-middle-income country reached a value of 279.78 HPV-related publications per GDP in 1000 bn US-$. Collaboration analysis pointed to the US as the center of the 4517 international HPV collaborations.The worldwide HPV-research landscape is dominated by North American and Western European countries. By contrast, a high prevalence of HPV-related cervical cancer is documented for low-income countries. Hence, HPV-related public health interventions and prevention research specifically tailored to these countries needs to be fostered by monetary support and international collaborations.

Cervical cancer in low and middle‑income countries (Review)

“…Despite the incidence of cervical cancer in many LMICs being lower than in many developed countries, the cancer burden in LMICs is increasing due to the advanced stage at diagnosis and inaccessible treatment (28). Thus, immediate action in the public and global health sectors is advised (2,138). Effective precancerous lesion detection using the PapilloCheck ® microarray and the HPV restriction fragment length polymorphism (RFLP) PCR assay was achieved with 62.5 and 25.0% HPV co-infection detection, respectively (4).…”

Global cervical cancer research: A scientometric density equalizing mapping and socioeconomic analysis

“…Additionally, one might also compare the present data to research on benign female neoplasms such as uterine fibroids/myomas [ 18 ]: This analysis covered the identical time span from 1900 to 2015; a title search was performed. However, it was not restricted to articles but included all other publications.…”

“…A key feature of the NewQIS method is the unique visualization of the computed results [ 18 ]. Therefore, density equalizing map projections (DEMP) were calculated for the different cervical carcinoma-specific parameters resulting in a variety of anamorphic maps.…”

Development of HPV16,18,31,45 E5 and E7 peptides-based vaccines predicted by immunoinformatics tools

“…With more than 200 genotypes, human papillomavirus (HPV) is the main reason for cervical cancer, and most common sexually transmitted viruses in the world (Bruggmann et al 2018). Based on the annual report of the International Agency for Research on Cancer evaluation (IARC), twelve types of HPVs (i.e.,16,18,31,33,35,39,45,51,52,56,58 and 59) were classified as high-risk types.…”

“…Based on the annual report of the International Agency for Research on Cancer evaluation (IARC), twelve types of HPVs (i.e.,16,18,31,33,35,39,45,51,52,56,58 and 59) were classified as high-risk types. Among high-risk HPV types, HPV 16, 18, 31 and 45 had the highest prevalence among women with cervical cancer in the world (Bruggmann et al 2018). HPV genome has an 8 kb circular double strand DNA that encodes eight open reading frames (ORFs) consisting of the early and late genes.…”