Human papillomavirus and World Health Organization type III nasopharyngeal carcinoma: Multicenter study from an endemic area in Southern China

Abstract

In regions that are endemic for NPC, the prevalence of EBV and HPV coinfection in patients with NPC is extremely low. Conversely, patients with EBV-/HPV+ NPC demonstrate significantly better local tumor control and survival after radiotherapy. Cancer 2018;124:530-6. © 2017 American Cancer Society.

Thyroid V50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study

“…Nasopharyngeal carcinoma (NPC) is common in southern China. Radiotherapy is the primary treatment, and the 5-year overall survival rate is up to about 80% [1,2]. Radiation inevitably damages normal tissue while treating tumors.…”

Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma: a multicenter study

“…Nasopharyngeal carcinoma (NPC) has a distinct histopathology and geographic distribution compared with other cancers of the head and neck [1,2]. The incidence in Southern China and Southeast Asia (endemic areas) is high, with most tumors being undifferentiated, nonkeratinizing carcinomas [3,4]. On the contrary, NPCs of nonendemic areas (such as Northern Europe) can be keratinizing or nonkeratinizing [5].…”

Human papillomavirus and World Health Organization type III nasopharyngeal carcinoma: Multicenter study from an endemic area in Southern China

“…In this endemic part of the world, it is well known that Epstein-Barr virus (EBV) plays an important role in the etiology of the cancer, and this is reflected in the results of this study, which shows that 91.9% of the patients had tumor cells that were positive for EBV. 1 However, the prevalence of human papillomavirus (HPV) infection in nasopharyngeal cancer in the endemic area is unknown.…”