Human Papillomavirus Genotype Distribution in Cytologically Screened Women from Northwest Germany

Jonge, Marthe M. de; Busecke, G; Heinecke, A.; Bettendorf, Olaf

doi:10.1159/000355099

Cited by 7 publications

(11 citation statements)

References 39 publications

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“…The association of HPV 73 and HPV82 with cervical epithelial lesions were confirmed and the two types were classified as HR type in previous studies [ 6 ],[ 39 ]. HPV 73 was even more risky than HPV 16 based on HPV-type-specific risk analysis in Bahia, Brazil [ 40 ] and Northwest Germany [ 41 ], which was consistent with our results in this study.…”

Section: Discussionsupporting

confidence: 91%

Human papillomavirus prevalence and type-distribution among women in Zhejiang Province, Southeast China: a cross-sectional study

Liu

Fan

et al. 2014

BMC Infect Dis

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BackgroundHuman papillomavirus (HPV) infection is the main etiological factor for cervical cancer and premalignant lesions of the cervix. The purposes of the present study were to determine the prevalence of type-specific HPV infections and the association of different HPV types with cervical dysplasia among women in Zhejiang province, Southeast China.MethodsA total of 15,267 women presenting to a gynaecological outpatient clinic were enrolled in this study. Women were screened for HPV in addition to routine cervical cytology testing. Microarray hybridization and liquid-based cytology tests were used to detect HPV genotypes and cervical cytology, respectively.ResultsBased on the population attending a gynaecological outpatient clinic, overall prevalence of any 23 HPV type was 22.8% and multiple HPV infection was found in 4.0% of all the outpatients. HPV prevalence showed bimodal age distribution, with a peak (55.7%) at the ≤20 age group and a second one (35.5%) at >60 age group. In total samples, the five most frequent types were HPV 16 (4.4%), 58 (2.9%), 52 (2.7%), 33 (2.2%) and 11 (1.9%). Overall HPV prevalence increased with the severity of the cytologic result. Analysis through crude odds ratios (ORs) revealed that the cervical lesion risk of HPV-infected women increased to about 26-fold of uninfected women (OR 26.1, 95% CI 22.4 to 30.3). The five most risky HPV types associated with abnormal cytology were HPV 73, 16, 82, 45 and 51.ConclusionsThis study provided baseline data on HPV prevalence in women attending a gynecological outpatient clinic in Zhejiang province. Our data will supply guidance for the primary screening and vaccination program for cervical cancer in this area.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-014-0708-8) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Human papillomavirus prevalence and type-distribution among women in Zhejiang Province, Southeast China: a cross-sectional study

Liu

Fan

et al. 2014

BMC Infect Dis

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“…The overall prevalence of any HPV in SCC samples was 92.2% and was 68.0% across all cervical samples investigated. HR‐HPV was detected in 64.8% of all samples with HPV‐16 being the most common HPV genotype identified, which is consistent with that described elsewhere in CIN cases across Europe in countries such as Spain, France, and Germany [García‐Espinosa et al, ; Monsonego et al, ; de Jonge et al, ; Leinonen et al, ; Rössler et al, ] and in invasive disease internationally [Bosch et al, ; de Sanjose et al, ; Li et al, ]. As previously reported the prevalence of HPV increased through CIN I–III lesions in NI [Anderson et al, ] from 48.1% in CIN I to 81.3% in CIN III cases.…”

Section: Discussionsupporting

confidence: 87%

HPV prevalence and type‐distribution in cervical cancer and premalignant lesions of the cervix: A population‐based study from Northern Ireland

Anderson¹,

O’Rorke²,

Wilson

et al. 2016

Journal of Medical Virology

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Assessment of Human papillomavirus (HPV) prevalence and genotype distribution is important for monitoring the impact of prophylactic HPV vaccination. This study aimed to demonstrate the HPV genotypes predominating in pre‐malignant and cervical cancers in Northern Ireland (NI) before the vaccination campaign has effect. Formalin fixed paraffin embedded tissue blocks from 2,303 women aged 16–93 years throughout NI were collated between April 2011 and February 2013. HPV DNA was amplified by PCR and HPV genotyping undertaken using the Roche® linear array detection kit. In total, 1,241 out of 1,830 eligible samples (68.0%) tested positive for HPV, with the majority of these [1,181/1,830 (64.5%)] having high‐risk (HR) HPV infection; 37.4% were positive for HPV‐16 (n = 684) and 5.1% for HPV‐18 (n = 93). HPV type‐specific prevalence was 48.1%, 65.9%, 81.3%, 92.2%, and 64.3% among cervical intraepithelial neoplasias (CIN) Grades I–III, squamous cell carcinomas (SCC) and adenocarcinoma (AC) cases, respectively. Most SCC cases (81.3%) had only one HPV genotype detected and almost a third (32.0%) of all cervical pathologies were HPV negative including 51.9% of CIN I (n = 283), 34.1% CIN II (n = 145), 18.7% of CIN III (n = 146), 7.8% of SCC (n = 5), and 35.7% of AC (n = 5) cases. This study provides important baseline data for monitoring the effect of HPV vaccination in NI and for comparison with other UK regions. The coverage of other HR‐HPV genotypes apart from 16 and 18, including HPV‐45, 31, 39, and 52, and the potential for cross protection, should be considered when considering future polyvalent vaccines. J. Med. Virol. 88:1262–1270, 2016. © 2015 Wiley Periodicals, Inc.

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“…Schiffman et al reported that HPV prevalence was 62%‐17% for ASC‐US, 86%‐56% for LSIL, and 96%‐78% for HSIL cases . HR HPV prevalence in Turkish women with abnormal cytology is similar to rates reported from other countries …”

Section: Discussionsupporting

confidence: 91%

“…In this study, the observed rates of HPV16 (15.7%) and HPV18 (2.9%) infection from cytologically normal samples in our study coincide with those in previous studies . HPV16 and HPV18 were more prevalent in samples with more severe cytological abnormalities ( P < .01).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of high‐risk human papilloma virus in liquid‐based cervical samples from Turkish women with normal and abnormal cytology

Şeneldir

Kır

2018

Diagnostic Cytopathology

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Background: The aim of this study was to investigate the prevalence of human papilloma virus (HPV) infection from Turkish women with normal and abnormal cytology.Methods: Our study population consisted of 1252 women with normal and abnormal cytology.In our clinic, cervical cancer screening was performed by liquid-based cytology testing (ThinPrep Pap Test). Reflex high-risk (HR) HPV testing (Cervista HPV HR and HPV 16/18) was performed in cases with abnormal cytology (n = 330). HR HPV testing was performed to 922 cases with normal cytology.Results: HR HPV was detected in 18.7% of negative for intraepithelial lesion or malignancy (NILM) samples, and in 79.7% of abnormal cytology cases. HPV types 16 and/or 18 were found in 18.6% and 35.3% of normal cytology cases and abnormal cytology cases, respectively. Of all 435 HR HPV-positive samples, HPV type 16 and/or 18 prevalence was significantly higher in cases with more severe cytological abnormalities. Conclusions:The HPV prevalence among Turkish women with normal and abnormal cytology identified in this study largely concurs with those in other studies throughout the world. HPV types 16 and/or 18 were detected significantly in normal cytology cases in our study. We also found that, as has been previously demonstrated, certain HPV genotypes (16/18) are associated with more severe pathologies. However, larger epidemiological studies in different regions of Turkey are needed to evaluate the accurate prevalence of HPV infection throughout the country. K E Y W O R D S cervical cytology, human papilloma virus, Turkey ;47:100-104.women and to investigate the role of HR HPV infections in women with normal and abnormal cervical cytology. | MATERIALS AND METHODS | Study population and specimen preparationThe study protocol was approved by the Ethics Committee of the Umraniye Education and Research Hospital. According to ethical standards in our country, an informed patient consent is not necessary due to the design of the retrospective study (the study database was created from a retrospective file review). Umraniye is a district of Istanbul which has received migrants from rural areas of Anatolia with low socio-economic level. The Department of Pathology's archives from November 2013 to May 2015 in the Umraniye Education and Research Hospital were searched to identify all women with cervical cytology records. Opportunistic cervical cancer screening in our hospital was performed by liquid-based cytology testing (ThinPrep Pap Test). Reflex HR HPV testing (Cervista HPV HR and Cervista HPV 16/18) was performed in all cases with abnormal cytology. Cases were selected if both molecular analysis and cytology were available. HR HPV testing was performed to 922 cases with normal cytology due to the patients' request and 412 cases with abnormal cytology. Cytological samples were classified according to the Bethesda 2001/2014 system as negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US), atypical squamous cells, cannot e...

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Human Papillomavirus Genotype Distribution in Cytologically Screened Women from Northwest Germany

Cited by 7 publications

References 39 publications

Human papillomavirus prevalence and type-distribution among women in Zhejiang Province, Southeast China: a cross-sectional study

Human papillomavirus prevalence and type-distribution among women in Zhejiang Province, Southeast China: a cross-sectional study

HPV prevalence and type‐distribution in cervical cancer and premalignant lesions of the cervix: A population‐based study from Northern Ireland

Prevalence of high‐risk human papilloma virus in liquid‐based cervical samples from Turkish women with normal and abnormal cytology

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