Human Papillomavirus in Benign and Malignant Ovarian and Endometrial Tissues

The role of Human papillomavirus in surface epithelial ovarian carcinoma with its effect on P53 and Retinoblastoma tumor suppressor genes

“…Many researchers suggested that HPV may be involved in the development of epithelial ovarian neoplasm's (Ip et al, 1992;Lai et al, 1992;Lai et al, 1994;Wu et al, 2003) similar to the present study. Additional studies looking for particular viral sequences like early protein 6, 7 and 5 in ovarian tissue may be required for final proof.…”

Detection of human papillomavirus-16 in ovarian malignancy

“…Only in four of the 10 studies, HPV infection was found in ovarian cancers (Lai et al, 1992(Lai et al, , 1994Zimna et al, 1997;Ip et al, 2002). It is interesting that in three of the positive reports, specimens of Chinese origin were used (Lai et al, 1992(Lai et al, , 1994Ip et al, 2002). In the present study, a total of 54 ovarian cancers and 30 nontumour ovarian specimens were analysed for the presence of HPV-16.…”

“…Therefore, the involvement of HPV infection in epithelial ovarian cancer has been an interesting issue. However, previous studies in different laboratories provided highly controversial results (Kaufman et al, 1987;Leake et al, 1989;Beckmann et al, 1991;Lai et al, 1992Lai et al, , 1994Duggan et al, 1995;Runnebaum et al, 1995;Sworn et al, 1995;Trottier et al, 1995;Anwar et al, 1996;Kedzia et al, 1996;Mai et al, 1996;Zimna et al, 1997;Manolitsas et al, 1998;Anttila et al, 1999;Chen et al, 1999;Ip et al, 2002). We report here that HPV-16 was found in a series of histologically characterised epithelial ovarian carcinomas from Chinese women.…”

“…To date about 16 additional reports on HPV infection in ovarian tumours were found in the MEDLINE. Among these, 10 analysed more than 10 tumour specimens in each report (Leake et al, 1989;Beckmann et al, 1991;Lai et al, 1992Lai et al, , 1994Runnebaum et al, 1995;Trottier et al, 1995;Zimna et al, 1997;Anttila et al, 1999;Chen et al, 1999;Ip et al, 2002). Only in four of the 10 studies, HPV infection was found in ovarian cancers (Lai et al, 1992(Lai et al, , 1994Zimna et al, 1997;Ip et al, 2002).…”

Atividade mucosotrópica do Papilomavírus Humano (HPV) no processo carcinogênico em diferentes sítios de infecção.

“…A transmissão peri-conceptual pode teoricamente ocorrer através do oócito infectado (CAMPOS et al, 2016) ou espermatozoide (SYRJÃNEN, 2010), o DNA do HPV já foi detectado no sémen (FORESTA et al, 2010), endométrio e ovários (LAI et al, 1992), sugerindo que essa transmissão pode ocorrer durante a fertilização ou imediatamente após (FREITAS et al, 2015).…”