Human papillomavirus-related head and neck adenosquamous carcinoma: A systematic review and individual patient data meta-analysis

Fiacchini, Giacomo; Benettini, Giacomo; Tricò, Domenico; Torregrossa, Liborio; Vianini, Matteo; Picariello, Miriana; Dallan, Iacopo; Berrettini, Stefano; Bruschini, Luca

doi:10.1016/j.oraloncology.2021.105252

Cited by 3 publications

(2 citation statements)

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“…A recent systematic study found that there was no statistically significant association between HPV16 and/or HPV18 positive and overall survival or disease-free survival of cervical cancer (20). In a study of adeno-squamous carcinoma of the head and neck, Giacomo et al suggested that HPV positive and HPVnegative tumors had similar OS and DFS (21). These findings support the present study.…”

Section: Discussionsupporting

confidence: 88%

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Impact of HR-HPV infection on oncological outcomes in early cervical cancer

Su,

Liu,

Zhao

et al. 2023

Front. Oncol.

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BackgroundThis study aimed to investigate the differences in long-term oncological outcomes between high-risk human papillomavirus (HR-HPV) negative and HR-HPV positive early-stage cervical cancers.MethodsWe retrospectively analysed 2061 cases of early-stage cervical cancer from the Chinese cervical cancer clinical diagnosis and treatment database. Kaplan-Meier curves were used to describe the survival outcomes of different HR-HPV infections. Cox proportional hazard regression model was used to analyze and determine independent risk factors.ResultsK-M analysis revealed no significant difference in 5-year OS between HR-HPV negative and HR-HPV positive groups (OS: 95.0% vs.95.6%, P=0.900). A significant difference was observed in 5-year DFS between the HR-HPV negative and HR-HPV positive groups (DFS: 87.2% vs.91.9%, P=0.025). Cox proportional hazard regression model indicated that HR-HPV infection (negative vs. positive) was an independent factor influencing 5-year DFS after early cervical cancer surgery (DFS: hazard ratio [HR]=1.862, P=0.022). HR-HPV infection (negative vs positive) was not an independent factor influencing 5-year OS after early cervical cancer surgery (OS: P=0.813). After 1:1 PSM pairing, there was no significant difference in 5-year OS and DFS between HR-HPV negative group and HR-HPV positive group (OS: 91.6% vs.95.0%, P=0.297; DFS: 87.2% vs.85.1%, P=0.758). Cox multivariate analysis indicated that HR-HPV infection was not an independent factor influencing 5-year OS and DFS after early cervical cancer surgery (OS: P=0.806, DFS: P=0.251).ConclusionsThe tumour results of HR-HPV negative group and HR-HPV positive group were similar, after eliminating the differences in known variables that affect the oncological outcomes of cervical cancer. The treatment plan of HR-HPV positive cervical cancer is suitable for HR-HPV negative cervical cancer.

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Section: Discussionsupporting

confidence: 88%

“…In a study of adeno-squamous carcinoma of the head and neck, Giacomo et al. suggested that HPV positive and HPV-negative tumors had similar OS and DFS ( 21 ). These findings support the present study.…”

Section: Discussionmentioning

confidence: 99%