Human pathogen nucleic acids in wastewater solids from 191 wastewater treatment plants in the United States

Boehm, Alexandria B.; Wolfe, Marlene K.; Bidwell, Amanda L.; Zulli, Alessandro; Chan-Herur, Vikram; White, Bradley J.; Shelden, Bridgette; Duong, Dorothea

doi:10.1038/s41597-024-03969-8

Sci Data

2024

DOI: 10.1038/s41597-024-03969-8

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Human pathogen nucleic acids in wastewater solids from 191 wastewater treatment plants in the United States

Alexandria B. Boehm,

Marlene K. Wolfe,

Amanda L. Bidwell

et al.

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2024

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Cited by 2 publications

References 42 publications

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Spatiotemporal Variability of the Pepper Mild Mottle Virus Biomarker in Wastewater

Rosengart,

Bidwell,

Wolfe

et al. 2024

ACS EST Water

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Spatiotemporal Variability of the Pepper Mild Mottle Virus Biomarker in Wastewater

Rosengart,

Bidwell,

Wolfe

et al. 2024

ACS EST Water

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SARS-CoV-2 surveillance in US wastewater: Leading indicators and data variability analysis in 2023–2024

Schenk,

Rauch,

Zulli

et al. 2024

PLoS ONE

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Wastewater-Based Epidemiology (WBE) has become a powerful tool for assessing disease occurrence in communities. This study investigates the coronavirus disease 2019 (COVID-19) epidemic in the United States during 2023–2024 using wastewater data from 189 wastewater treatment plants in 40 states and the District of Columbia. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pepper-mild mottle virus normalized SARS-CoV-2 RNA concentration data were compared with COVID-19 hospitalization admission data at both national and state levels. We further investigate temporal features in wastewater viral RNA abundance, with peak timing and cross-correlation lag analyses indicating that wastewater SARS-CoV-2 RNA concentrations precede hospitalization admissions by 2 to 12 days. Lastly, we demonstrate that wastewater treatment plant size has a significant effect on the variability of measured SARS-CoV-2 RNA concentrations. This study highlights the effectiveness of WBE as a non-invasive, timely and resource-efficient disease monitoring strategy, especially in the context of declining COVID-19 clinical reporting.

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Human pathogen nucleic acids in wastewater solids from 191 wastewater treatment plants in the United States

Cited by 2 publications

References 42 publications

Spatiotemporal Variability of the Pepper Mild Mottle Virus Biomarker in Wastewater

Spatiotemporal Variability of the Pepper Mild Mottle Virus Biomarker in Wastewater

SARS-CoV-2 surveillance in US wastewater: Leading indicators and data variability analysis in 2023–2024

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