Human peptidoglycan recognition protein 1 in innate immunity

Yang, Jie

doi:10.1080/23312025.2018.1450917

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…3C). We first identified PGLYRP1 + neutrophil with specific roles in innate immunity [35], as well as MX1 + antiviral neutrophil [36], and SLPI + inhibitory neutrophil [37]. Another three subpopulations were labeled by P2RY13, PRRG4 and S100P, all of which took part in neutrophil functions.…”

Section: Non-t Immune Cell Subpopulations and Their Intercellular Interaction Patternsmentioning

confidence: 99%

A single-cell interactome of human tooth germ from growing third molar elucidates signaling networks regulating dental development

Shi

Zhou

et al. 2021

Cell Biosci

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Background Development of dental tissue is regulated by extensive cell crosstalk based on various signaling molecules, such as bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) pathways. However, an intact network of the intercellular regulation is still lacking. Result To gain an unbiased and comprehensive view of this dental cell interactome, we applied single-cell RNA-seq on immature human tooth germ of the growing third molar, discovered refined cell subtypes, and applied multiple network analysis to identify the central signaling pathways. We found that immune cells made up over 80% of all tooth germ cells, which exhibited profound regulation on dental cells via Transforming growth factor-β, Tumor necrosis factor (TNF) and Interleukin-1. During osteoblast differentiation, expression of genes related to extracellular matrix and mineralization was continuously elevated by signals from BMP and FGF family. As for the self-renewal of apical papilla stem cell, BMP-FGFR1-MSX1 pathway directly regulated the G0-to-S cell cycle transition. We also confirmed that Colony Stimulating Factor 1 secreted from pericyte and TNF Superfamily Member 11 secreted from osteoblast regulated a large proportion of genes related to osteoclast transformation from macrophage and monocyte. Conclusions We constructed the intercellular signaling networks that regulated the essential developmental process of human tooth, which served as a foundation for future dental regeneration engineering and the understanding of oral pathology.

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Section: Non-t Immune Cell Subpopulations and Their Intercellular Interaction Patternsmentioning

confidence: 99%