Human periosteum-derived progenitor cells express distinct chemokine receptors and migrate upon stimulation with CCL2, CCL25, CXCL8, CXCL12, and CXCL13

Stich, Stefan; Loch, Alexander; Leinhase, Iris; Neumann, Katja; Kaps, Christian; Sittinger, Michael; Ringe, Jochen

doi:10.1016/j.ejcb.2008.03.009

Cited by 70 publications

(58 citation statements)

References 39 publications

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“…Subsequently, it has been reported that PDC express chemokine receptors from the four chemokine subfamilies; CC, CXC, CX(3)C, and C. Furthermore, they are responsive to the chemokines CCL2 (monocyte chemoattractant protein-1, MCP1), CCL25 (thymus expressed chemokine, TECK), CXCL8 (interleukin 8, IL8), CXCL12 (SDF1α) and CXCL13 (B-cell-activating chemokine 1, BCA1) [67]. In addition, PDC respond to a number of growth factors and cytokines.…”

Section: Isolation and Characterization Of Skeletal Progenitor Cells mentioning

confidence: 99%

Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath

Roberts

Gastel

Carmeliet

et al. 2015

Bone

209

186

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The cartilage- and bone-forming properties of the periosteum have long since been recognized. As one of the major sources of skeletal progenitor cells, the periosteum plays a crucial role not only in bone development and growth, but also during bone fracture healing. Aided by the continuous expansion of tools and techniques, we are now starting to acquire more insight into the specific role and regulation of periosteal cells. From a therapeutic point of view, the periosteum has attracted much attention as a cell source for bone tissue engineering purposes. This interest derives not only from the physiological role of the periosteum during bone repair, but is also supported by the unique properties and marked bone-forming potential of expanded periosteum-derived cells. We provide an overview of the current knowledge of periosteal cell biology, focusing on the cellular composition and molecular regulation of this remarkable tissue, as well as the application of periosteum-derived cells in regenerative medicine approaches. This article is part of a Special Issue entitled "Stem Cells and Bone".

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Section: Isolation and Characterization Of Skeletal Progenitor Cells mentioning

confidence: 99%

Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath

Roberts

Gastel

Carmeliet

et al. 2015

Bone

209

186

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“…MDC did not induce in vitro migration by human periostium-derived MSC. 125 These studies suggest that chemokine-induced migration may depend on the systemic and local inflammatory state and that MSC receptors may vary with tissue source.…”

Section: Rantes MDCmentioning

confidence: 99%

In SituTissue Regeneration: Chemoattractants for Endogenous Stem Cell Recruitment

Berg-Foels

2014

Tissue Engineering Part B: Reviews

132

111

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Tissue engineering uses cells, signaling molecules, and/or biomaterials to regenerate injured or diseased tissues. Ex vivo expanded mesenchymal stem cells (MSC) have long been a cornerstone of regeneration therapies; however, drawbacks that include altered signaling responses and reduced homing capacity have prompted investigation of regeneration based on endogenous MSC recruitment. Recent successful proof-of-concept studies have further motivated endogenous MSC recruitment-based approaches. Stem cell migration is required for morphogenesis and organogenesis during development and for tissue maintenance and injury repair in adults. A biomimetic approach to in situ tissue regeneration by endogenous MSC requires the orchestration of three main stages: MSC recruitment, MSC differentiation, and neotissue maturation. The first stage must result in recruitment of a sufficient number of MSC, capable of effecting regeneration, to the injured or diseased tissue. One of the challenges for engineering endogenous MSC recruitment is the selection of effective chemoattractant(s). The objective of this review is to synthesize and evaluate evidence of recruitment efficacy by reported chemoattractants, including growth factors, chemokines, and other more recently appreciated MSC chemoattractants. The influence of MSC tissue sources, cell culture methods, and the in vitro and in vivo environments is discussed. This growing body of knowledge will serve as a basis for the rational design of regenerative therapies based on endogenous MSC recruitment. Successful endogenous MSC recruitment is the first step of successful tissue regeneration

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“…PDGF is an established chemoattractant factor for cells of stromal origin (33). Moreover, chemokines including CCL-2 (MCP-1), CXCL-8 (IL-8), and CXCL-12 (SDF-1) have been implicated in stromal cell migration (34)(35)(36). The concentrations of chemokines in fracture and surgically cut supernatants were examined using the Luminex xMAP system.…”

Section: Osteogenic Differentiation Is Restricted To Muscle Cells Adjmentioning

confidence: 99%

TNF-α promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

Glass

Chan

Freidin³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

340

295

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With an aging population, skeletal fractures are increasing in incidence, including the typical closed and the less common open fractures in normal bone, as well as fragility fractures in patients with osteoporosis. For the older age group, there is an urgent unmet need to induce predictable bone formation as well as improve implant fixation in situations such as hip joint replacement. Using a murine model of slow-healing fractures, we have previously shown that coverage of the fracture with muscle accelerated fracture healing and increased union strength. Here, we show that cells from muscle harvested after 3 d of exposure to an adjacent fracture differentiate into osteoblasts and form bone nodules in vitro. The osteogenic potential of these cells exceeds that of adipose and skinderived stromal cells and is equivalent to bone marrow stromal cells. Supernatants from human fractured tibial bone fragments promote osteogenesis and migration of muscle-derived stromal cells (MDSC) in vitro. The main factor responsible for this is TNF-α, which promotes first MDSC migration, then osteogenic differentiation at low concentrations. However, TNF-α is inhibitory at high concentrations. In our murine model, addition of TNF-α at 1 ng/mL at the fracture site accelerated healing. These data indicate that manipulating the local inflammatory environment to recruit, then differentiate adjacent MDSC, may be a simple yet effective way to enhance bone formation and accelerate fracture repair. Our findings are based on a combination of human specimens and an in vivo murine model and may, therefore, translate to clinical care.

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Human periosteum-derived progenitor cells express distinct chemokine receptors and migrate upon stimulation with CCL2, CCL25, CXCL8, CXCL12, and CXCL13

Cited by 70 publications

References 39 publications

Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath

Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath

In SituTissue Regeneration: Chemoattractants for Endogenous Stem Cell Recruitment

TNF-α promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

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