Human pituitary thyrotropin. Characterization of five glycoproteins with thyrotropin activity

Jacobson, Gunilla B.; Roos, Paul; Wide, Leif

doi:10.1016/0005-2795(77)90015-0

Cited by 12 publications

(3 citation statements)

References 16 publications

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“…Nine individuals, five women and four men (aged years, median 64 years) without any thyroid disease, and five patients, four women and one man (aged 45-73 years, median 62 years) with nontoxic nodular goiter were given highly purified human thyrotropin (6,7). The investigation was ap¬ proved by the ethics committee.…”

Section: Subjectsmentioning

confidence: 99%

Basal and Thyrotropin-Stimulated Secretion Rates of Thyroglobulin from the Human Thyroid Gland during Surgery

Tegler¹,

Ericsson²,

Gillquist³

et al. 1993

Thyroid

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The secretion rates of thyroglobulin were measured under basal conditions and after exogenous and endogenous thyrotropin stimulation in 23 patients during surgery. In 11 patients with normal thyroid glands the median secretion rate of thyroglobulin was 0.7 pmol/24 h. Higher secretion rates were observed in 8 patients with nontoxic nodular goiter (median 22 pmol/24 h; p < 0.001) and in 4 patients with thyroid malignancy (median 2.2 pmol/24h; p < 0.05). Within 10 min after administration of highly purified human thyrotropin into the thyroid artery an increase of the secretion rates was observed in the 9 patients studied with normal thyroid glands and 5 patients with nontoxic nodular goiter. TRH administration to 5 patients induced a slight but nonsignificant increase of the secretion rate of thyroglobulin after 20 min. These results show that thyroglobulin is secreted directly into the thyroid venous blood. They also confirm that thyrotropin is an important regulator of the thyroglobulin secretion.

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Section: Subjectsmentioning

confidence: 99%

Basal and Thyrotropin-Stimulated Secretion Rates of Thyroglobulin from the Human Thyroid Gland during Surgery

Tegler¹,

Ericsson²,

Gillquist³

et al. 1993

Thyroid

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“…The pituitary glycoproteins exist as a variety of heterogeneous species with widely different physical and immunological characteristics. The extent of the microheterogeneity of the pituitary glycoproteins has been demonstrated by the isolation from the human pituitary of at least 30 forms of FSH (Wide, 1985), seven iso-hormones of LH (Lichtenberg et ul., 1984) and five glycoproteins with thyrotrophin activity (Jacobson et al, 1977). The heterogeneity relates in part to the composition of the carbohydrate moieties and in part to molecular weight variants.…”

Section: Changes In Biological Activitymentioning

confidence: 99%

The Role of Modern Bioassays in Clinical Endocrinology

Robertson

Lambert

Loveridge

1987

Clinical Endocrinology

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“…One hyperparathyroid pa¬ tient had a lymphocytic Hashimoto's thyroiditis, and was treated with thyroxine 0.15 mg daily for 6 weeks preoperatively because of hypothyroidism. At the time of surgery all patients were clinically and biochemically euthyroid, with normal serum concentrations of thyro¬ xine (T») and 3,3',5-triiodothyronine (T3) (Mitsuma et (Roos et al 1975;Jacobson et al 1977). This preparation, which was available in only limited supply, and which was radioimmunoassayed using TSH 63/14 MRC research Standard A (Roos et al 1975), was admini¬ stered in doses graded from 12.5 to 1200 mU in the same way as above.…”

mentioning

confidence: 99%

Human thyroid blood flow response to endogenous, exogenous human, and bovine thyrotrophin measured by electromagnetic flowmetry

Tegler¹,

Gillquist²,

Anderberg³

et al. 1981

Acta Endocrinologica

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Human thyroid blood flow (TBF) was studied with electromagnetic flowmetry during operation. Measurements were made of the effect on TBF of injections of bovine TSH into one inferior thyroid artery in 6 patients; 6 other patients were given human TSH, and in 10 patients measurements were made both of TBF and endogenous TSH released after administration of TRH in a peripheral vein.The TBF increased after all three types of injection. The mean of the TBF maxima after bovine TSH was 2.26 \ m=+-\ 0.35 (mean \ m=+-\sem) relative to basal TBF, after human TSH 1.97 \m=+-\0. 28, and after TRH 1.64 \ m=+-\0.20. In the three groups combined it was 1.92 \m=+-\0.16. The TBF was often increased already during the first recording period 1\p=n-\10min after TSH or TRH administration. The mean TBF was approximately doubled at 30\p=n-\50min. There were considerable inter-individual variations in the latent time and maximum response of TBF, especially after human TSH, but we found no correlation between the response and the TSH serum concentration in any group.A prompt, but inter-individually varying, increase in TBF was confirmed. This increase is suggested to be secondary to an increased intrafollicular metabolic activity and not primarily regulating the thyroid function.

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Human pituitary thyrotropin. Characterization of five glycoproteins with thyrotropin activity

Cited by 12 publications

References 16 publications

Basal and Thyrotropin-Stimulated Secretion Rates of Thyroglobulin from the Human Thyroid Gland during Surgery

Basal and Thyrotropin-Stimulated Secretion Rates of Thyroglobulin from the Human Thyroid Gland during Surgery

The Role of Modern Bioassays in Clinical Endocrinology

Human thyroid blood flow response to endogenous, exogenous human, and bovine thyrotrophin measured by electromagnetic flowmetry

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