Human PK Prediction and Modeling

Grasela, Thaddeus H.; Lukáčová, Viera; Morris, Denise; Clark, Richard D.; Andrews, Kayla; Bolger, Michael B.

doi:10.1016/b978-0-12-409547-2.12373-x

Cited by 1 publication

(1 citation statement)

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“…Among these, the liver is a major organ of the reticuloendothelial system, also known as the monocyte-phagocytic system, which contains gatekeeper cells like sinusoidal endothelial cells or Kupffer cells, capable of clearing foreign particles in blood circulation[ 6 ]. In addition, enterohepatic circulation includes the transportation of substances absorbed by enterocytes through portal flow and the passage of bile into the intestine via the biliary tracts[ 7 ]. This re-entry cycle can cause repeated exposure of MPs/NPs to hepatocytes and sequelae in the liver.…”

Section: Introductionmentioning

confidence: 99%

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Chiang,

Yeh,

Shiu

et al. 2024

World J Gastroenterol

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With continuous population and economic growth in the 21st century, plastic pollution is a major global issue. However, the health concern of microplastics/ nanoplastics (MPs/NPs) decomposed from plastic wastes has drawn public attention only in the recent decade. This article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ, which is one of the primary routes that MPs/NPs enter human bodies. The interrelated mechanisms including oxidative stress, hepatocyte energy re-distribution, cell death and autophagy, as well as immune responses and inflammation, were also featured. In addition, the disturbance of microbiome and gut-liver axis, and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease, steatohepatitis, liver fibrosis, and cirrhosis were briefly discussed. Finally, we discussed potential directions in regard to this trending topic, highlighted current challenges in research, and proposed possible solutions.

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Section: Introductionmentioning

confidence: 99%