Human Placenta-Derived Adherent Cells Improve Cardiac Performance in Mice With Chronic Heart Failure

Abstract

The therapeutic effects of PDA‐001 in mice with chronic heart failure (CHF) were tested. Three weeks after transaortic constriction surgery to induce CHF, the mice underwent direct injection of PDA‐001. Intramyocardial injection of PDA‐001 significantly improved left ventricular systolic and diastolic function and decreased cardiac fibrosis, demonstrating the cardiac therapeutic potential of PDA‐001.

Towards the standardization of stem cell therapy studies for ischemic heart diseases: Bridging the gap between animal models and the clinical setting

“…The advantages and limitations of each stem cell with regard to the possible emergence of ethical concerns (symbolized by ¥), the invasiveness and collection (from + to ++++), the isolation procedure, the abundance (from + to ++++), expansion and proliferation rate, the transdifferentiation capacity, the paracrine effects or/and cardiomyogenic potential, the survival and engraftment capacity as well as the immunogenic, oncogenic or teratogenic risks is given in the accessory side tables. The left table abridges bone marrow-derived stem cells [3,[19][20][21]27,28], cortical bone-derived stem cells [32,33], adipose tissue-derived stem cells [34,37,39,41] and gestation-related stem cells [42][43][44][45][46][47][48][49]51,54] and the right table abridges cardiac stem cells [57,59,60], skeletal muscle stem cells [62,63,66] and induced pluripotent stem cells [67,[69][70][71]. The human body scheme was constructed with images sourced from Servier Medical Art (http://www.servier.com/ Powerpoint-image-bank) and Cientic website (http://www.cientic.com/).…”

“…Pregnancy byproducts represent an important source of stem cells which can be obtained from a plethora of sources, such as placenta [42][43][44], chorionic plate [45], amniotic fluid [46], umbilical cord [47,48] and its blood [48][49][50][51]. These immune-privileged materials offer several advantages (Fig.…”

“…These immune-privileged materials offer several advantages (Fig. 1), like their non-invasive, safe and ethically accepted collection, their large availability, as well as their higher expansion and proliferation abilities than any other adult stem cell [42][43][44][45]. Furthermore, unlike adult stem cells, pregnancy-associated stem cells are not primed by senescence or disease conditions, thus making them good candidates for regenerative medicine [42].…”

“…This would be particularly important for elder patients, whose stem cell quality is expected to reduce with age [12]. Similarly to the above stem cell groups, it is thought that these cells act mainly through paracrine activity, stimulating vascularization, cardiomyogenesis, and inhibiting inflammation, fibrosis and apoptosis [42][43][44][45]47,48,51]. Also related to gestation, MSCs obtained from fetal heart tissue (fC-MSC) and embryonic stem cells (ESC) have been proposed as alternative multipotent cells with the ability to differentiate into CMs, endothelial and smooth muscle cells.…”

Body Management: Mesenchymal Stem Cells Control the Internal Regenerator

“…The helicopter picks the patient up and brings him to an urban medical center for treatment. In 5-10 years, that same patient might drive to a local clinic or urgent care center and be given an infusion of MSCs intravenously as the total or firstline treatment [65]. In such cases, it might be that patients "bank" frozen bags of their own MSCs for use in crisis management.…”