Human placental lactogen (HPL) and placental weight

Sciarra, John J.; Sherwood, Louis M.; Varma, André; Lundberg, Walter B.

doi:10.1016/0002-9378(68)90075-6

Cited by 76 publications

(28 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The increase in maternal peripheral serum levels of hPL as pregnancy advances can be correlated directly with the mass of the placental tissue (144). The rate of secretion of hPL in pregnant women (1 g day-I) is the greatest of any protein hormone in man and is a major placental secretory product accounting for 10% of all placental protein production at term (61, 169).…”

Section: Protein Hormone Production By the Placentamentioning

confidence: 99%

Endocrine Physiology of the Placenta

Simpson¹,

MacDonald²

1981

Annu. Rev. Physiol.

225

View full text Add to dashboard Cite

Section: Protein Hormone Production By the Placentamentioning

confidence: 99%

Endocrine Physiology of the Placenta

Simpson¹,

MacDonald²

1981

Annu. Rev. Physiol.

225

View full text Add to dashboard Cite

“…Most of the positive clones encoded the entire pro-PL protein of 217 amino acid residues, and all were identified as PL-4 transcript variant 1. The expression of PL-4 and PL-3, which result in identical mature hormones, is initiated and up-regulated in placental syncytiotrophoblasts during pregnancy, with the highest expression levels at term (19,43). The PL-4 gene transcript variant 1 that contains all five exons of the gene encodes isoform 1, the most abundant full-length isoform of the hormone (44).…”

Section: Pl Expression In Breast Cancermentioning

confidence: 99%

Lysyl Oxidase Interacts with Hormone Placental Lactogen and Synergistically Promotes Breast Epithelial Cell Proliferation and Migration

Polgár

Fogelgren

Shipley

et al. 2007

Journal of Biological Chemistry

View full text Add to dashboard Cite

Lysyl oxidase (LOX), an extracellular amine oxidase, catalyzes the cross-linking of collagen and elastin. LOX has been also shown to play an essential role in promoting the invasive and metastatic potential of breast tumor cells. However, the LOXinteracting factors in these processes are not known. In this study, we identified placental lactogen (PL), a member of the growth hormone/prolactin hormone family, as a LOX-interacting partner using yeast two-hybrid screens. PL is normally only expressed in placental syncytiotrophoblasts, but PL genes are amplified and expressed in a high percentage of invasive ductal breast carcinomas. We confirmed LOX-PL interactions using far Western and solid phase binding assays. In activity assays, PL was not a substrate or inhibitor of LOX. We further demonstrated that PL is expressed in breast tumor epithelial cells and detected LOX-PL interactions by coimmunoprecipitation in invasive breast cancer cells. In MCF-10A normal breast epithelial cells stably expressing LOX, PL, or both, LOX had no effect on cell proliferation, PL alone increased proliferation by 49%, and coexpression of LOX and PL led to a 121% increase in cell proliferation. Unlike in tumor cells, LOX did not induce a more migratory phenotype in MCF-10A cells; nor did PL. However, their coexpression resulted in a 240% increase in cell migration, suggesting that these interactions may be highly relevant to the transition of epithelial cells toward a migratory phenotype during the development and progression of breast carcinoma and a significant role for LOX-PL interactions in epithelial cell behavior.

show abstract

“…This correlation and diagnostic reliability with respect to SGA has been confirmed [40,64,79,80,83,85]. Others found a relation to placen-'tal weight [5, 73,74] not confirmed by SCIARRA et al [75]. The great ränge of normal HPL levels in the last trimester has often been considered to limit the value and clinical use of this test [77,79].…”

Section: Resultsmentioning

confidence: 90%

Ultrasound and biochemical findings in intrauterine growth retardation

Kunz¹,

Keller²

1976

Journal of Perinatal Medicine

View full text Add to dashboard Cite

The early recognition of fetal maldevelopment due to chronic placental insufficiency is of decisive importance if perinatal mortality and morbidity are to be further reduced. This can be achieved by direct and indirect methods, i.e. cephalometry and thoracometry using ultrasound on the one hand, and biochemical tests of the function of the fetoplacental unit, on the other. Estriol, pregnandiol and HPL levels and some placental enzymes are here of special interest. In this investigation an attempt was made to asses the diagnostic value of the various parameters and to suggest when they should be used. Jürg KUNZ, born 1942, Zürich, Studied medicine at University of Zürich, 1962-69 Curriculum vitae l Material and methodA total of 83 patients presently, or with a case history of risk hospitalised because of suspect placental insufficiency, was investigated. Twin pregnancies and those with doubtful duration were excluded. In the third trimester of pregnancy the following determinations were made: An average of 4 determinations of the biparietal head diameter using the B-scan method (Vidoson), 10 determinations of estriol and 3 of pregnandiol in urine [13,50] and 6 HPL determinations in the semm [49], 7 determinations of heat stable alkaline phosphatase (HSAP) [9], all per individual case. Biparietal head diameter values were transferred to a Standard curve that was in agreement with the one reported by HOLLÄNDER [42]. Growth retardation was assumed if the last two values showed the same trend with the date being certain and were below two Standard deviations or showed decreased progress. Biochemical parameters were considered to be pathological if they were below 95% of the normal values, with two values being outside this normal ränge or with 3 or more values being continuously below the 95% normal ränge. Maturity was assessed after birth from neurological and somatic signs of maturity according to D u BÖ-WITZ [25]. Infants were diagnosed äs small for date if their birth weight was below the lOth percentile on the LUBCHENKO curve [62]. ResultsFifteen of the 83 newborn were small for dates. Five had a gestational age of less than 37 weeks, 4 in the 35/36 week and one in the 30.5 week. A further 11 prematures was in the group of 68 normotrophic children. However, only 3 out of the 15 small for date infants were below the lower limit of the norm. The remaining 81 (98%) were within nonnal limits, 71 % below the curve for mean values. In twelve SGA infants the head diameter was normal prenatally and increased normally. Fig. 2 shows a very good correlation between weight percentile and the percentage deviation from the normal mean of estriol excretion. In all SGA cases values were found to be decreased. Ten were outside the 95% normal limits and 5 were still at least 40% below those limits. In infants with body weights between the lOth and 50 th percentile estriol values were below, the normal mean in 44%.Weight percentiles and HPL concentration in maternal serum ( Fig. 3) also correlated well. In 8 out of 15 SGA inf...

show abstract

Human placental lactogen (HPL) and placental weight

Cited by 76 publications

References 10 publications

Endocrine Physiology of the Placenta

Endocrine Physiology of the Placenta

Lysyl Oxidase Interacts with Hormone Placental Lactogen and Synergistically Promotes Breast Epithelial Cell Proliferation and Migration

Ultrasound and biochemical findings in intrauterine growth retardation

Contact Info

Product

Resources

About