Human population dynamics and
            <i>Yersinia pestis</i>
            in ancient northeast Asia

Kılınç, Gülşah Merve; Kashuba, Natalija; Koptekin, Dilek; Bergfeldt, Nora; Dönertaş, Handan Melike; Rodríguez-Varela, Ricardo; Shergin, Dmitrij; Ivanov, Grigorij Leonidovich; Kichigin, Dmitrii; Pestereva, Kiunnei A.; Volkov, D.P.; Mandryka, Pavel V.; Kharinskii, Artur; Tishkin, Alexey A.; Ineshin, Evgenij; Kovychev, Evgeniy; Степанов, А. Д.; Dalén, Love; Günther, Torsten; Kırdök, Emrah; Jakobsson, Mattias; Somel, Mehmet; Krzewińska, Maja; Storå, Jan

doi:10.1126/sciadv.abc4587

Cited by 46 publications

(53 citation statements)

References 102 publications

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“…Population genomics from human archaeological finds can help to obtain a better understanding about past migrations and population affinities [ 4 , 5 , 8 ]. By analysing both the human and non-human fraction of ancient DNA, we can explore these past people and the microorganisms that were associated with them [ 15 , 22 , 73 , 88 ]. In this research we have combined a human population genomics analysis with that of the oral bacterium T. forsythia .…”

Section: Discussionmentioning

confidence: 99%

Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome

White

de-Dios

Carrión

et al. 2021

Biology

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The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition of past populations in Central Asia holds value to understanding human mobility in this pivotal region. In this study, we analyse paleogenomic data generated from five humans from Kuygenzhar, Kazakhstan. These individuals date to the early to mid-18th century, shortly after the Kazakh Khanate was founded, a union of nomadic tribes of Mongol Golden Horde and Turkic origins. Genomic analysis identifies that these individuals are admixed with varying proportions of East Asian ancestry, indicating a recent admixture event from East Asia. The high amounts of DNA from the anaerobic Gram-negative bacteria Tannerella forsythia, a periodontal pathogen, recovered from their teeth suggest they may have suffered from periodontitis disease. Genomic analysis of this bacterium identified recently evolved virulence and glycosylation genes including the presence of antibiotic resistance genes predating the antibiotic era. This study provides an integrated analysis of individuals with a diet mostly based on meat (mainly horse and lamb), milk, and dairy products and their oral microbiome.

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Section: Discussionmentioning

confidence: 99%

Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome

White

de-Dios

Carrión

et al. 2021

Biology

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“…The Altaic languages, including Mongolic, Tungusic, and Turkic, are widely distributed in northern East Asia, Siberia, and part region of Central Asia. Previous studies from a genetic perspective have mainly demonstrated the northern East Asian affinity of Mongolic and Tungusic-speaking populations based on the genome-wide single-nucleotide polymorphism (SNP) data or sharing IBD fragments (Yunusbayev et al, 2015;Pugach et al, 2016;Jeong et al, 2020;Kilinc et al, 2021). Based on the large-scale sampling of the ancient and present-day populations from Mongolia, Lake Baikal, to Amur River Basin, it is observed that the Mongolians and Tungusic-speaking groups have a higher proportion of genetic component related to the Devil's Gate people who were early Neolithic hunter-gatherers in northeastern East Asia dating to more than 7.7 thousand years ago (Siska et al, 2017), as well as Mongolians Neolithic people (Jeong et al, 2020;.…”

Section: Introductionmentioning

confidence: 99%

Genomic Insights Into the Admixture History of Mongolic- and Tungusic-Speaking Populations From Southwestern East Asia

Chen

He²,

Ren

et al. 2021

Front. Genet.

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As a major part of the modern Trans-Eurasian or Altaic language family, most of the Mongolic and Tungusic languages were mainly spoken in northern China, Mongolia, and southern Siberia, but some were also found in southern China. Previous genetic surveys only focused on the dissection of genetic structure of northern Altaic-speaking populations; however, the ancestral origin and genomic diversification of Mongolic and Tungusic–speaking populations from southwestern East Asia remain poorly understood because of the paucity of high-density sampling and genome-wide data. Here, we generated genome-wide data at nearly 700,000 single-nucleotide polymorphisms (SNPs) in 26 Mongolians and 55 Manchus collected from Guizhou province in southwestern China. We applied principal component analysis (PCA), ADMIXTURE, f statistics, qpWave/qpAdm analysis, qpGraph, TreeMix, Fst, and ALDER to infer the fine-scale population genetic structure and admixture history. We found significant genetic differentiation between northern and southern Mongolic and Tungusic speakers, as one specific genetic cline of Manchu and Mongolian was identified in Guizhou province. Further results from ADMIXTURE and f statistics showed that the studied Guizhou Mongolians and Manchus had a strong genetic affinity with southern East Asians, especially for inland southern East Asians. The qpAdm-based estimates of ancestry admixture proportion demonstrated that Guizhou Mongolians and Manchus people could be modeled as the admixtures of one northern ancestry related to northern Tungusic/Mongolic speakers or Yellow River farmers and one southern ancestry associated with Austronesian, Tai-Kadai, and Austroasiatic speakers. The qpGraph-based phylogeny and neighbor-joining tree further confirmed that Guizhou Manchus and Mongolians derived approximately half of the ancestry from their northern ancestors and the other half from southern Indigenous East Asians. The estimated admixture time ranged from 600 to 1,000 years ago, which further confirmed the admixture events were mediated via the Mongolians Empire expansion during the formation of the Yuan dynasty.

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“…Younger representatives of this lineage exhibit admixture with the west Eurasian population after its movement into Northeast Asia (e.g., Salkhit [Mongolia] dating to ~34,000 cal BP, AR19K [Amur River Basin] dating to ~19,000 cal BP) (Mao et al, 2021; Massilani et al, 2020; Yu et al, 2020), and the Ancient Native American (ANA) 1 genome reflects as much as 30%–40% contribution from the West Eurasian lineage (e.g., Mao et al, 2021; Yang et al, 2020). The East Asian lineage is present in the Lena Basin (central Siberia) by ~17,000 cal BP and in western arctic Beringia by 10,000 cal BP (Kılınç et al, 2021; Sikora et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Multiple occurrences of the rare Uto‐Aztecan premolar variant in Hungary point to ancient ties between populations of western Eurasia and the Americas

Scott

Dern

Évinger

et al. 2022

Intl J of Osteoarchaeology

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The Uto-Aztecan premolar (UAP) is a rare dental morphological variant long thought to be restricted to non-Arctic Native Americans. The recent discovery of four individuals with this trait in a Hungarian sample invites reassessment of its geographic distribution.Our goal is to assess the variation of this trait on a global level and provide an explanation for its distribution. Observations on over 300 medieval Hungarian dentitions, along with data from the C.G. Turner II database, provide the authors with a global perspective on the distribution of UAP. In addition to four instances of UAP from Hungary, additional European cases have been reported from Germany, Spain, Yugoslavia, and France.Although the trait is most common in non-Arctic Native Americans, it is absent in Africa, Arctic America, the Pacific, and Asia with a few isolated and problematic exceptions.Most papers on UAP have focused on the trait's presence in the Americas with some authors suggesting a possible New World mutation. Although rare outside of the Americas, four examples from Hungary, in addition to other reported cases from Europe, suggest a more complex history of the UAP. Recent paleogenomic research indicates that direct gene flow from a west Eurasian lineage to an Ancient Native American population may have taken place after their divergence from the ancestral Arctic Native American population (Ancient Paleo-Siberians), thus explaining its current distribution among Europeans and non-Arctic Native Americans.

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Human population dynamics and Yersinia pestis in ancient northeast Asia

Cited by 46 publications

References 102 publications

Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome

Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome

Genomic Insights Into the Admixture History of Mongolic- and Tungusic-Speaking Populations From Southwestern East Asia

Multiple occurrences of the rare Uto‐Aztecan premolar variant in Hungary point to ancient ties between populations of western Eurasia and the Americas

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