Human prenatal exposure to polychlorinated biphenyls (PCBs) and risk behaviors in adolescence

Abstract

Polychlorinated biphenyls (PCBs) are chemicals used in a variety of products before they were widely banned due to toxic effects in humans and wildlife. Because of continued persistence and ubiquity of these contaminants, risk of exposure to people living in industrialized countries is still high. Experimental research show that developmental exposure to PCB may alter function of brain pleasure centers and potentially influence disinhibitory behaviors, including tobacco and alcohol use. Yet, the potential effects of developmental PCB exposure on adolescent substance use have not been studied in humans. We used the Child Health and Development Studies (CHDS), a prospective birth cohort study in the Oakland and East Bay areas of California, to investigate associations between prenatal exposure to PCB congeners (66, 74, 99, 118, 138, 153, 170, 180, 187, and 203) and later disinhibitory behaviors in adolescents, specifically alcohol consumption and smoking, in a randomly selected sample( n = 554). Total prenatal PCB exposure was not associated with disinhibitory behaviors, among adolescents. However, the adjusted odds ratio (aOR) for being a current smoker, was higher in subjects within the third quartile of maternal PCB 66 exposure compared to those below the median (aOR = 1.93; 95% CI 1.05, 3.55). The aOR for drinking > 2 alcoholic beverages per week, were also higher for adolescents within the third (aOR = 1.46; 95% CI 0.86, 2.47) and fourth quartile of PCB 66 exposure (aOR = 1.39; 95% CI 0.83, 2.35), but the differences did not reach statistical significance. These results suggest that this specific PCB congener may play a role inducing neurodevelopmental alterations that could potentially increase the risk of becoming a long-term user of tobacco and possibly alcohol. There were no notable differences between magnitude or direction of effect between boys and girls. Future replicate analyses with larger longitudinal samples and animal experimental studies of potential underlying mechanisms are warranted.

The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models

“…Regarding alcohol consumption, TCDD seems not to affect alcohol consumption in mice with high and low alcohol preference [ 93 ]. In humans, prenatal exposure to polychlorinated biphenyls, some of which are in the dioxin family, appears to increase the risk of becoming tobacco and alcohol users [ 94 ].…”

Effects of intrauterine exposure to 2,3′,4,4′,5‐pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring

“…The organ coefficients of brains and testes were altered in male offspring, indicating that PCB118 exposure during fetal PGC migration had an impact on fetal development (Figure 2 and Figure 3). Studies have shown that prenatal exposure to PCBs can significantly alter the developmental processes of the fetal nervous and reproductive systems (Dickerson, Ransome, & Karlsson, 2019; Grandjean et al, 2012). Our present research indicated that PCB118 exposure in utero affected the reproductive health of male offspring.…”

The Multifaced Actions of Curcumin in Pregnancy Outcome

“…PolyChlorinated Biphenyls (PCBs) belong to a broad family of organic compounds exposure to which leads to health problems including cancer [ 61 , 62 ], endometriosis [ 63 ] and neurologic problems [ 64 , 65 ]. PCBs can pass through the placenta reaching the fetus but they can also be released in the human milk [ 66 ] and reach the newborn having significant toxicologic effects by interrupting the neurodevelopmental processes [ 67 ].…”