Human pulp response to acid pretreatment of dentin and to composite restoration

Stanley, Harold R.; Going, Robert E.; Chauncey, Howard H.

doi:10.14219/jada.archive.1975.0455

Cited by 135 publications

(49 citation statements)

References 14 publications

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“…Many functional monomers have been developed to provide dental materials having excellent adhesive properties and high strength. However, it has been pointed out that such materials occasionally cause pulp irritation [1][2][3][4][5] . Furthermore, there are many reports on the cytotoxic effects of the hydrophobic compounds included in composite resins, such as Bis-GMA and TEGDMA or their analogues [6][7][8][9][10][11][12][13][14][15][16][17][18][19] , which is also related to the problem of environmental estrogens by bisphenol A.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic effects of acrylic acid, methacrylic acid, their corresponding saturated carboxylic acids, HEMA, and hydroquinone on fibroblasts derived from human pulp

Kurata

Morishita

Kawase

et al. 2012

Dental Materials Journal

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The purpose of this study was to evaluate the cytotoxicity of acrylic and methacrylic acid (AA and MA), propanoic acid and isobutylic acid (PRA and IBA) which were the corresponding saturated carboxylic acids, 2-hydroxylethyl methacrylate and acrylate (HEMA and HEA), and hydroquinone (HQ). The growth of the fibroblast when exposed to AA decreased with increase of the acid, and was less than when exposed to MA. The growth when exposed to their corresponding saturated acids, PRA and IBA, showed a similar tendency to AA and MA. The growth of fibroblasts exposed to 5 mmol/L HEMA after 4 days and 3 mmol/L HEMA after 6 days was significantly different compared with that without HEMA. The growth in 1, 3, and 5 mmol/L of HEA after 2 days was markedly decreased compared with that without HEA, and the cells were probably lifeless. The growth when exposed to HQ was extremely lower than their acids.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic effects of acrylic acid, methacrylic acid, their corresponding saturated carboxylic acids, HEMA, and hydroquinone on fibroblasts derived from human pulp

Kurata

Morishita

Kawase

et al. 2012

Dental Materials Journal

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show abstract

“…Many functional monomers have been developed to provide dental materials having excellent adhesive properties and high strength. However, it has been pointed out that the residual monomers eluted from organic base materials occasionally cause pulp irritation and allergies [1][2][3][4][5] . Many reports on the cytotoxicity of bisphenol-A derivatives and other dimethacrylate monomers, such as bisphenol-A diglycidyl methacrylate (Bis-GMA), triethyleneglycol dimethacrylate (TEGDMA), and urethane dimethacrylate (UDMA) et al have been published [6][7][8][9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic effects of polybasic acids, poly(alkenoic acid)s, and the monomers with various functional groups on human pulp fibroblasts

et al. 2011

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This study evaluated the cytotoxicity of various polybasic acids, poly(alkenoic acid)s, and the monomers with various acidic functional groups such as carboxyl, phosphoryl, and sulfo group. The cell growth of fibroblasts cultivated in medium containing polybasic acids and polymers up to the concentration to 5 mmol/L was not significantly different compared with that of control without their acids. On the other hand, the cell growth fibroblasts cultivated in medium containing 1 mmol/L of the monomers with acryloyloxy and phosphoryl or carboxyl group decreased remarkably compared with that of the control and the cells were probably lifeless. Those exposed to the monomers with a ether bond and a carboxyl group or a amide bond and a sulfo group was not significantly different compared with that of control.

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“…This treatment is indicated when the pulp is accidentally exposed during cavity preparation 23 or by trauma and should be done immediately, or at least 24h after its occurrence 2 . Calcium hydroxide continues to be the most accepted material for pulp capping.…”

Section: Introductionmentioning

confidence: 99%

MTA and calcium hydroxide for pulp capping

2008

Dental Abstracts

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ABSTRACThis study evaluated the biocompatibility of mineral trioxide aggregate (MTA) after direct capping of exposed pulp tissue in dog's teeth. Class I cavities were prepared in 26 teeth from 3 adult dogs. MTA was applied over the exposed pulp in 13 teeth and paste of calcium hydroxide plus distilled water (control) was applied in the remaining 13 teeth. After 90 days, the animals were killed; the maxilla and mandible were dissected and sectioned to obtain individual roots. The samples were processed histologically. The pulp and periapical response observed with the use of MTA was similar to that of calcium hydroxide paste. In all specimens, there was a dentin bridge obliterating the exposure, an intact odontoblastic layer, no inflammatory cells, normal connective pulp tissue, normal apical and periapical regions and no bone tissue changes. Similar to calcium hydroxide, MTA presented excellent response when used for direct pulp capping. Uniterms: Dental pulp capping; Calcium hydroxide; Mineral trioxide aggregate. objetivo deste trabalho foi avaliar a biocompatibilidade do agregado de trióxido mineral (MTA), após proteção pulpar direta em dentes de cães. Foram preparadas cavidades de Classe I, em 26 dentes de 3 cães adultos. O MTA foi aplicado sobre 13 dentes e a pasta de hidróxido de cálcio (grupo controle) foi aplicada sobre os 13 dentes remanescentes. Após 90 dias, os animais foram mortos, a maxila e a mandíbula foram dissecadas e os dentes foram seccionados para obtenção de raízes individualizadas. Os espécimes foram processados histologicamente. A resposta do tecido pulpar e periapical foi semelhante para o MTA e o hidróxido de cálcio. Em todos os espécimes havia ponte de dentina obliterando o local da exposição pulpar, camada odontoblástica íntegra, ausência de células inflamatórias, tecido pulpar normal, e ausência de alterações na região periapical e óssea. Da mesma maneira que o hidróxido de cálcio, o MTA apresentou excelente biocompatibilidade quando usado para proteção pulpar direta. Unitermos: Capeamento da polpa dentária; Hidróxido de cálcio; Agregado de trióxido mineral.

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Human pulp response to acid pretreatment of dentin and to composite restoration

Cited by 135 publications

References 14 publications

Cytotoxic effects of acrylic acid, methacrylic acid, their corresponding saturated carboxylic acids, HEMA, and hydroquinone on fibroblasts derived from human pulp

Cytotoxic effects of acrylic acid, methacrylic acid, their corresponding saturated carboxylic acids, HEMA, and hydroquinone on fibroblasts derived from human pulp

Cytotoxic effects of polybasic acids, poly(alkenoic acid)s, and the monomers with various functional groups on human pulp fibroblasts

MTA and calcium hydroxide for pulp capping

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