Human sebum extract induces barrier disruption and cytokine expression in murine epidermis

Guo, Jiun‐Wen; Lin, Tzu Kai; Wu, Chin Han; Wei, Kai; Lan, C.‐C. E.; Peng, A; Tsai, Jui Chen; Sheu, Hamm Ming

doi:10.1016/j.jdermsci.2015.01.010

Cited by 26 publications

(17 citation statements)

References 30 publications

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“…Sebum levels on the forehead rapidly increase following birth, more markedly in females, thought to result from a flood of maternal androgens during labour . Experimental work in a murine model demonstrated that the topical application of sebum proves detrimental to structural surface SC lipids, subsequently elevating TEWL, reducing hydration, and initiating a proinflammatory cascade . An interesting question remains, therefore, as to the effect of excess surface sebum on the infant epidermal barrier, which warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

Chittock

Cooke

Lavender

et al. 2016

British Journal of Dermatology

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Conflicts of interest disclosure: None to declare. What's already known about this topic? From birth the acidification and hydration of the infant stratum corneum to adult levels suggests transitory mechanisms underlying differentiation and desquamation. What does this study add? Superficial chymotrypsin-like protease activity and natural moisturising factors (NMF) increase from birth to 4 weeks of age and differ to adults. Impaired barrier function at birth is accompanied by elevated protease activity and reduced NMF, highlighting why certain infants are predisposed to epidermal barrier breakdown and the development of atopic dermatitis. AbstractBackground: From birth, the functional properties of the neonatal epidermal barrier mature whereby

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Section: Discussionmentioning

confidence: 99%

Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

Chittock

Cooke

Lavender

et al. 2016

British Journal of Dermatology

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“…MD has been used to investigate the structure and phase behaviour of a single component SC lipid model in water [22][23][24][25][26] . In addition, more complex mixtures consisting of ceramides, cholesterol and free fatty acids have been investigated to assess the impact of the lipid composition on the permeability, structure and fluidity of the SC membrane 18,[27][28][29][30][31] . The permeation of small molecules 19 , ethanol 19,32 , DMSO 19,22 , oils 33,34 and nanoparticles 35,36 has also been quantified using MD simulations 2 .…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides

Tascini

Noro

Seddon

et al. 2019

Phys. Chem. Chem. Phys.

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“…Sebum on the skin surface might be a major factor favoring the proliferation and colonization of C acnes . Significant correlations have been reported between sebum levels and the number, proportion, and location of acne lesions …”

Section: Introductionmentioning

confidence: 99%

“…Significant correlations have been reported between sebum levels and the number, proportion, and location of acne lesions. 6,7 Currently, all acne treatment regimens usually include attempts to reverse the pathogenesis of acne development. Retinoids prevent the hyperproliferation of keratinocytes, while benzoyl peroxide decreases the population of C acnes.…”

Section: Introductionmentioning

confidence: 99%

A cleanser formulated with Tris (hydroxymethyl) aminomethane andl‐arginine significantly improves facial acne in male Thai subjects

Kumtornrut

Manabe²,

Navapongsiri³

et al. 2019

J of Cosmetic Dermatology

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Background Acne is one of the most common skin problems among human populations. A facial cleanser formulated with alkyl ether carboxylate (AEC) and alkyl carboxylate (AC) can improve acne by cleansing sebum on facial skin but cannot effectively remove keratotic plugs in the skin pores. Recently, we confirmed that Tris (hydroxymethyl) aminomethane and L‐arginine (Tris/Arg) is able to reduce sebum levels, disrupt keratotic plugs in vitro and decrease pore size on facial skin. Objective To compare the efficacy of the Tris/Arg‐formulated cleanser with the AEC/AC cleanser in Thai subjects with acne. Methods We designed a randomized, double‐blind, controlled, parallel trial. Thirty‐four male Thai subjects with mild to moderate acne were assigned to one of two groups: one group used the Tris/Arg cleanser while the other used the AEC/AC‐based cleanser twice a day for 4 weeks. Results After 4 weeks, significant decreases in noninflammatory acne were observed in both groups, yet significant decreases in inflammatory acne were only observed in the Tris/Arg cleanser group. The sebum level prior to and 30 minutes after facial washing showed no change in either group. The average pore size with keratotic plugs on the cheeks was significantly decreased in the Tris/Arg group. More than half of subjects in both groups observed acne improvement but more subjects in the Tris/Arg group noted pore size improvement. Conclusion The Tris/Arg formulated cleanser has a high efficacy for significantly reducing both noninflammatory and inflammatory acne accompanied by decreases in pore size with keratotic plugs in male Thai subjects.

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Human sebum extract induces barrier disruption and cytokine expression in murine epidermis

Cited by 26 publications

References 30 publications

Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides

A cleanser formulated with Tris (hydroxymethyl) aminomethane andl‐arginine significantly improves facial acne in male Thai subjects

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