Human serum immunoglobulin concentrations: Prevalence of immunoglobulin deficiencies+

Cassidy, James T.; Nordby, Gordon L.

doi:10.1016/s0091-6749(75)80006-6

Cited by 103 publications

(60 citation statements)

References 35 publications

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“…A discussion of SIgMID is notably absent in recently published practice parameters on primary immunodeficiencies from expert panels [37]. The prevalence of SIgMID has been reported to be less than SIgAID in an unselected group of 3,213 individuals ages 4-87 [1]. In the atopic population, the prevalence of both SIgAID (4.5%) and SIgMID (ranging from 1.56-22%) may be higher than in the general population [38].…”

Section: Discussionmentioning

confidence: 99%

“…In our review, 1 pediatric patient with a complete deficiency of IgM was identified, reflecting the rarity of such an occurrence [16]. In Cassidy's population of 3213 unselected Caucasian individuals, only 1 patient had undetectable serum IgM levels (0.03% incidence) [1]. Common with other primary immunodeficiencies, recurrent sinopulmonary infections were present in 74.5% of pediatric SIgMID cases (Table 4).…”

Section: T Cell Functionsmentioning

confidence: 99%

“…Selective IgM immunodeficiency (SIgMID) is a dysgammaglobulinemia characterized by an isolated low level of serum IgM, usually <20 mg/dL in infants and children or <2 standard deviations or 10% below age adjusted means [1][2][3]. Usually, serum IgM levels are <10-20 mg/dL [3].…”

Section: Introductionmentioning

confidence: 99%

“…It is said to be a rare primary immunodeficiency, with the prevalence of completely deficient IgM patients reported as approximately 0.03% in a community-based study. [1] However, the prevalence of those with deficient but detectable levels of IgM is closer to 0.1-3.0% in hospitalized patients [1,4,5], 1.6% in an unselected community health screening [1,6], 0.07% in an allergy and immunology clinic [7], and 0.26% in an adult allergy and immunology clinic [8]. There is a slightly higher penetration of SIgMID in males (1.97%) versus females (1.42%) [1].…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Selective Igm Immunodeficiency

Goldstein

Dunsky

et al. 2008

Chest

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Objective. Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed. Methods. English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed. Results. Fortynine reported cases of SIgMID presented with respiratory infections (77.6%), gastrointestinal disease (16.3%), skin disease (12.2%), and meningitis (8.2%). Mean serum IgM level was 16.5 ± 13.8 mg/dL. Two patients were identified with SIgMID among 6300 active pediatric patients (0.03%) presenting with asthma, vasomotor rhinitis, and recurrent respiratory infections. In the 51 cases reported, none developed lymphoproliferative disease nor evolved into panhypogammaglobulinemia; four fatalities were reported. Conclusions. The prevalence of SIgMID in our pediatric population was 0.03%. In general, respiratory infections are the common comorbid conditions. Death and autoimmune disease are uncommon complications of pediatric SIgMID.

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Section: Discussionmentioning

confidence: 99%

Section: T Cell Functionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pediatric Selective Igm Immunodeficiency

Goldstein

Dunsky

et al. 2008

Chest

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“…Selective IgM deficiency is a rare form of primary immunodeficiency that has been reported to have a prevalence ranging from 0.03% to 0.3% [1]. Selective IgM deficiency can be asymptomatic or may symptomatically present with infections from encapsulated bacteria and viruses, some of which can be serious and even lifethreatening infections varying from pneumonia to septicemia and meningitis [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Selective IgM Deficiency with T Cell Defects and Mycobacterium Avium Complex (MAC) Infection

Gupta¹

2012

TOIJ

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Primary selective IgM deficiency in adults is associated with normal T cell function, and patients clinically manifest with recurrent pyogenic bacterial infections. In this study, we present three patients with selective IgM deficiency with significant defects in T cells and NK cell cytotoxicity, and Mycobacterial avium intracellulare (MAC) infection. T cell defect is characterized by markedly reduced numbers of T cells and T cell subsets, decreased T cell proliferative responses to mitogens and antigens, including PPD, and significantly decreased production of IFN-; however, expression of IFN-receptors is normal. We propose that selective IgM deficiency with significant T cell functional defects might represent a distinct clinical entity, which is associated with increased susceptibility to MAC infection.

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Safety of Intravenous Immunoglobulin

Thornton¹

1993

Archives of Neurology

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Human serum immunoglobulin concentrations: Prevalence of immunoglobulin deficiencies+

Cited by 103 publications

References 35 publications

Pediatric Selective Igm Immunodeficiency

Pediatric Selective Igm Immunodeficiency

Selective IgM Deficiency with T Cell Defects and Mycobacterium Avium Complex (MAC) Infection

Safety of Intravenous Immunoglobulin

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