While there is burgeoning interest in the influence of human resource management (HRM) on sustainability organizational outcomes (SOO), the intricate interplay with Occupational Health and Safety (OHS) has not yet been explored, particularly in manufacturing firms’ contexts. Therefore, this study aims to probe the symbiotic relationship between HRM practices, OHS, and SOO, spotlighting manufacturing firms. Data collection was conducted by utilizing a cross-sectional survey, convenience sampling technique, and a web-based form among the 256 respondents from an industrial company (Balexco) in Bahrain. Structural Equation Modeling (SEM) by Smart-PLS was used to analyze the collected data. Our analysis highlighted a significant positive relationship between HRM, SOO, and OHS. Moreover, this study highlighted the dual impact of direct and indirect HRM on SOO, mediated by OHS. These multi-layered insights reinforce the assumption that a comprehensive approach to HRM, aligning performance aspirations with employee well-being, is instrumental in improving SOO. This study is a novel contribution to the literature because, by uncovering the intricate interplay of HRM, OHS, and SOO, practical implications and limitations were provided.