Human Skin Aging Is Associated with Reduced Expression of the Stem Cell Markers β1 Integrin and MCSP

Giangreco, Adam; Goldie, Stephen J.; Failla, Virgilio; Saintigny, Gaëlle; Watt, Fiona M.

doi:10.1038/jid.2009.297

Cited by 108 publications

(108 citation statements)

References 20 publications

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“…Previous studies seem to indicate that this progressive expression decrease alters epidermis via defects in integrin signaling rather than cell adhesion (Bosset et al, 2003;Giangreco et al, 2010). Our data showing a similar reduction of CD98hc expression during aging strengthen massive and efficient contribution in skin homeostasis, in particular in the situation of high epidermal renewal phase (hair growth and wound healing).…”

Section: Discussionsupporting

confidence: 74%

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CD98hc (SLC3A2) regulation of skin homeostasis wanes with age

Boulter¹,

Estrach²,

Errante³

et al. 2013

J Cell Biol

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Skin aging is linked to reduced epidermal proliferation and general extracellular matrix atrophy. This involves factors such as the cell adhesion receptors integrins and amino acid transporters. CD98hc (SLC3A2), a heterodimeric amino acid transporter, modulates integrin signaling in vitro. We unravel CD98hc functions in vivo in skin. We report that CD98hc invalidation has no appreciable effect on cell adhesion, clearly showing that CD98hc disruption phenocopies neither CD98hc knockdown in cultured keratinocytes nor epidermal 1 integrin loss in vivo. Instead, we show that CD98hc deletion in murine epidermis results in improper skin homeostasis and epidermal wound healing. These defects resemble aged skin alterations and correlate with reduction of CD98hc expression observed in elderly mice. We also demonstrate that CD98hc absence in vivo induces defects as early as integrin-dependent Src activation. We decipher the molecular mechanisms involved in vivo by revealing a crucial role of the CD98hc/integrins/Rho guanine nucleotide exchange factor (GEF) leukemia-associated RhoGEF (LARG)/RhoA pathway in skin homeostasis. Finally, we demonstrate that the deregulation of RhoA activation in the absence of CD98hc is also a result of impaired CD98hc-dependent amino acid transports.

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Section: Discussionsupporting

confidence: 74%

“…Finally, decrease in epidermal 1 integrin expression level is associated with aging, a phenomenon which is accentuated in photo-exposed skin (Bosset et al, 2003;Giangreco et al, 2010).…”

mentioning

confidence: 99%

CD98hc (SLC3A2) regulation of skin homeostasis wanes with age

Boulter¹,

Estrach²,

Errante³

et al. 2013

J Cell Biol

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“…As a person ages, basal keratinocyte proliferation is reduced, resulting in an overall thinning of the epidermis (Kligman 1979;Montagna and Carlisle 1979;Lavker 1995), and the dermal -epidermal junction appears flattened with shorter epidermal rete pegs and dermal rete ridges (Lavker et al 1987). These features also occur with photoaging, although to a more variable extent (Lavker 1995;Giangreco et al 2010). Flattening of the dermal -epidermal junction is thought to reduce the exchange surface between epidermis and dermis, reduce the nutrient flux, and thereby might have a role in reducing keratinocyte proliferation (Lavker et al 1989).…”

Section: Effects Of Aging On Skin Barrier and Thermoregulation Functionsmentioning

confidence: 99%

Natural and Sun-Induced Aging of Human Skin

Rittié

Fisher

2015

Cold Spring Harbor Perspectives in Medicine

424

386

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With worldwide expansion of the aging population, research on age-related pathologies is receiving growing interest. In this review, we discuss current knowledge regarding the decline of skin structure and function induced by the passage of time (chronological aging) and chronic exposure to solar UV irradiation ( photoaging). Nearly every aspect of skin biology is affected by aging. The self-renewing capability of the epidermis, which provides vital barrier function, is diminished with age. Vital thermoregulation function of eccrine sweat glands is also altered with age. The dermal collagenous extracellular matrix, which comprises the bulk of skin and confers strength and resiliency, undergoes gradual fragmentation, which deleteriously impacts skin mechanical properties and dermal cell functions. Aging also affects wound repair, pigmentation, innervation, immunity, vasculature, and subcutaneous fat homeostasis. Altogether, age-related alterations of skin lead to age-related skin fragility and diseases. S kin, like many other organs, undergoes deleterious changes with the passage of time and associated hormonal and dietary variations. Unlike most other organs, however, skin is also directly affected by exposure to the environment, especially UV irradiation from the sun. Chronic exposure to UV irradiation causes an aged phenotype ( photoaging) that is superimposed with aging caused by the passage of time (chronological aging). As a result, areas of the body that are frequently exposed to the sun such as the face, neck, forearms, or back of the hands acquire visible signs of aging more rapidly than other areas of the body.Skin serves two vital functions. First, skin serves as a barrier; it protects physical, chemical, and bacteriological intrusion in the body, and prevents dehydration by evaporative water loss. Second, skin allows thermoregulation through regulation of skin-hosted vasculature and eccrine sweat glands. In addition to these vital functions, skin mediates the sense of touch and plays a role in immune surveillance, hormone production, and social communication. Each of these functions is affected with aging. In general, alterations of skin structure and function appear earlier and are more pronounced in photoaged than in chronologically aged skin. Evidently, photoaging is a cumulative process and, as such, is more severe in older individuals.Passage of time and repeated exposure to harmful aspects of the environment alter both the epidermal and dermal compartments of the skin. Clinically, chronologically aged skin ap-

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“…Identifying stem cell subpopulations and their specific markers is of great interest for epidermal stem cell biology, as the stem cell contribution to such diverse skin changes as cancer, baldness, wound repair, and skin aging is barely understood (Paus and Cotsarelis 1999;PerezLosada and Balmain 2003;Giangreco et al 2010;Arwert et al 2012;Plikus et al 2012). …”

Section: Discussionmentioning

confidence: 99%