Human skin stem cell-derived hepatic cells as in vitro drug discovery model for insulin-driven de novo lipogenesis

Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation

“…Sterol-regulatory element binding proteins (mainly SREBP1c and SREBP2) are essential transcription factors activating the expression of genes in DNL and cholesterol synthesis 59 , 60 and promoting inflammation, and they are crucial for MAFL and MASH formation. 61 In agreement with the phenotypes in LKO or A 1 R Liver OE mice, the maturation and nuclear translocation process of SREBPs was stimulated by A 1 R deletion and inhibited by A 1 R overexpression, as well as consistent observation by A 1 R antagonist DPCPX or agonist CPA in vitro .…”