Human small intestine contains 2 functionally distinct regulatory T-cell subsets

Chauhan, Sudhir Kumar; Bartolomé-Casado, Raquel; Landsverk, Ole J. B.; Johannessen, Hanna; Phung, Danh; Nilsen, Hogne Røed; Sætre, Frank; Jahnsen, Jørgen; Horneland, Rune; Yaqub, Sheraz; Aandahl, Einar Martin; Lundin, Knut E.A.; Bækkevold, Espen S.; Jahnsen, Frode L.

doi:10.1016/j.jaci.2023.02.030

Cited by 3 publications

(2 citation statements)

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“…One year after duodenal transplantation, donor‐derived regulatory CD4 + FOXP3 + T cell populations and CD25 + CD127 − CD4 + T cells were still detected, 9 but low cell counts hindered further analysis. In a recent study, Chauhan et al 41 found that human SI Foxp3 + CD4 + Treg cells had two distinct subpopulations that could be distinguished based on the expression of the transcription factor Helios. These two sub‐populations have different lifespans.…”

Section: Tissue‐resident Memory T Cellsmentioning

confidence: 99%

“…One year after duodenal transplantation, a certain number of donor Helios-negative Tregs were still detected, whereas the number of Helios-positive Treg cells decreased rapidly within 1 year. 41 Foxp3 − Treg cells are also present in the gut, and the most characterized of these are Type 1 regulatory T (Tr1) cells. 36,42,43 Tr1 cells secrete large amounts of IL-10 and exert antiinflammatory effects.…”

Section: Resident Regulatory and Unconventional T Cells In The Intestinementioning

confidence: 99%

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Research progress on intestinal tissue‐resident memory T cells in inflammatory bowel disease

Chen,

Gu,

Yang

et al. 2023

Scand J Immunol

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Tissue‐resident memory T (TRM) cells are a recently discovered subpopulation of memory T cells that reside in non‐lymphoid tissues such as the intestine and skin and do not enter the bloodstream. The intestine encounters numerous pathogens daily. Intestinal mucosal immunity requires a balance between immune responses to pathogens and tolerance to food antigens and symbiotic microbiota. Therefore, intestinal TRM cells exhibit unique characteristics. In healthy intestines, TRM cells induce necessary inflammation to strengthen the intestinal barrier and inhibit bacterial translocation. During intestinal infections, TRM cells rapidly eliminate pathogens by proliferating, releasing cytokines, and recruiting other immune cells. Moreover, certain TRM cell subsets may have regulatory functions. The involvement of TRM cells in inflammatory bowel disease (IBD) is increasingly recognized as a critical factor. In IBD, the number of pro‐inflammatory TRM cells increases, whereas the number of regulatory subgroups decreases. Additionally, the classic markers, CD69 and CD103, are not ideal for intestinal TRM cells. Here, we review the phenotype, development, maintenance, and function of intestinal TRM cells, as well as the latest findings in the context of IBD. Further understanding of the function of intestinal TRM cells and distinguishing their subgroups is crucial for developing therapeutic strategies to target these cells.

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Section: Tissue‐resident Memory T Cellsmentioning

confidence: 99%