Human sorbin is generated via splicing of an alternative transcript from the ArgBP2 gene locus

Forensic Diagnosis of Acute Myocardial Infarction: Application of Mass Spectrometry

“…Using LC/MS, we found the marker Sorbin and SH3 domain-containing protein-2, (SORBS2) [16]. Another signature is ARGBP2, which interacts with Arg-ABL binding proteins via SH3 domains at its carboxyl end (Figure 2) [29][30][31][32]. This protein carries 3 Cterminal SH3 domains [33] and an N-terminal sorbin homology (SoHo) domain that interact with lipid-raft proteins.…”

Genotype–phenotype analysis of 4q deletion syndrome: Proposal of a critical region

“…FGF2 helps to determine bone mass as well as bone formation [Montero et al, 2000]. [Hand and Eiden, 2005] Clefts and congenital heart defects AD, autosomal dominant; AR, autosomal recessive; CNS, central nervous system; VSD, ventricular septal defect.…”

“…The protein is highly expressed in epithelia and cardiac muscle tissue. It has been found that the gene product interacts with ARG and c-ABL proteins [Hand and Eiden, 2005]. High expression level in cardiac tissue suggests that this gene may play an important role in heart development and may potentially contribute to CHD in patients with 4q deletion syndrome.…”

SORBS2 (sorbin and SH3 domain containing 2)

“…Sorbin, a 153 amino acid peptide, was isolated from porcine intestine (Vagne-Descroix et al, 1991). As a matter of fact, human sorbin is spliced from an alternative transcript from the SORBS2/ArgBP2 gene locus (Hand and Eiden, 2005). The sorbin homology domain is a motif for the targeting of proteins to lipid rafts (Kimura et al, 2001); 3 proteins present the SoHo domain: SORBS2/ArgBP2, SORBS1 (also called c-Cbl-associated protein (CAP), or ponsin) (10q24), and SORBS3 (vinexin) (8p21).…”