Human spermbots for patient-representative 3D ovarian cancer cell treatment

Abstract

Cellular micromotors are attractive for locally delivering high concentrations of drug, and targeting hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means. Spermatozoa are...

Application of CT Ultrasonography Combined with Microscopic Intraperitoneal Hyperthermic Perfusion Chemotherapy in Postoperative Treatment of Oocyst Carcinoma

“…Direct contact with the injured part of the patient reduces the risk of adverse patient reactions and ensures high safety. Some scholars have shown in the results of their research reports the use of hyperthermia that can kill tumor cells in patients, so the combined application of hyperthermia and chemotherapy for tumor patients can help to enhance the effect of treatment, control the patient's lesions, and further reduce the volume of the lesions, it has a very important application value for the treatment and recovery of patients [ 22 , 23 ].…”

Research Progress of Micro/Nanomotors for Cancer Treatment

“…Different from over-passaged Hela cells in previous studies, the earlypassage ovarian cancer cells from patients have higher specificity to represent patients. [21] It will be the popular research trends for biological micro/ nanomotors to integrate the cells or bacteria components with synthetic materials to build a hybrid micro/nanomotors with biological functions, and then expand their application in the biomedical field based on the inherent biological functions and the self-propulsion ability of micro/nanomotors.…”

Immunomodulation and delivery of macrophages using nano-smooth drug-loaded magnetic microrobots for dual targeting cancer therapy

“…Recently, natural self-propelled sperm emerged as promising biohybrid microrobots for active targeting delivery. Recent work on the treatment of cervical and ovarian cancer spheroids using magnetically controlled guided sperm robots loaded with chemotherapeutic agents ( Xu et al., 2018 , 2020a ) demonstrated the vast potential of eukaryotic cell-based microrobots for targeted cancer therapies.…”