Human spleen contains different subsets of dendritic cells and regulatory T lymphocytes

Velásquez‐Lopera, Margarita María; Correa, Luis Alfonso; García, Luis F.

doi:10.1111/j.1365-2249.2008.03734.x

Cited by 53 publications

(36 citation statements)

References 37 publications

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“…CD141 + DCs only account for a minor population of DCs in the blood. CD1c+ and CD141 + DCs have also been identified not only in the human spleen and LN (McIlroy et al, 2001; Poulin et al, 2012; Segura et al, 2012; Velasquez-Lopera, Correa, & Garcia, 2008) but also in the bronchoalveolar lavage fluid, lung, tonsils, decidua, and kidney (Ban, Kong, Qu, Yang, & Ma, 2008; Demedts, Brusselle, Vermaelen, & Pauwels, 2005; Fiore et al, 2008; Haniffa et al, 2012; Jongbloed et al, 2010; Lindstedt, Lundberg, & Borrebaeck, 2005; Tsoumakidou, Tzanakis, Papadaki, Koutala, & Siafakas, 2006; Yu et al, 2013). …”

Section: The Human DC Lineagementioning

confidence: 99%

Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases

Berres

Allen

Mérad

2013

Advances in Immunology

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Histiocytic disorders represent a group of complex pathologies characterized by the accumulation of histiocytes, an old term for tissue-resident macrophages and dendritic cells. Langerhans cell histiocytosis is the most frequent of histiocytosis in humans and has been thought to arise from the abnormal accumulation of epidermal dendritic cells called Langerhans cells. In this chapter, we discuss the origin and differentiation of Langerhans cells and dendritic cells and present accumulated evidence that suggests that Langerhans cell histiocytosis does not result from abnormal Langerhans cell homeostasis but rather is a consequence of misguided differentiation programs of myeloid dendritic cell precursors. We propose reclassification of Langerhans cell histiocytosis, juvenile xanthogranuloma, and Erdheim–Chester disease as inflammatory myeloid neoplasias.

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Section: The Human DC Lineagementioning

confidence: 99%

Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases

Berres

Allen

Mérad

2013

Advances in Immunology

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“…Mouse studies showed that in inflammatory conditions, Tregs accumulate in draining lymph nodes (LNs). 4 Tregs are found in T-cell 5 and B-cell areas 6,7 of mouse and human lymphoid organs. In lymphoid organs of mice, Tregs suppress conventional T-cell (Tconv) priming, 8,9 reduce Tconv expansion, 4,10 and limit egress of Tconvs.…”

Section: Introductionmentioning

confidence: 99%

Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells

Peters

Koenen

Fasse

et al. 2013

Blood

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“…It is not clear whether cDC in human blood are precursors or similar to fully differentiated, functional human spleen DC subsets. Initial histology-based studies of human spleen revealed heterogeneity of DC (21,29), but detailed phenotypic and functional studies of human spleen DC are lacking, due to restricted access to human spleen of suitable quality. Moreover, the health status of organ donors needs to be considered in studies of DC.…”

Section: Endritic Cells (Dc) Process and Present Self And Foreignmentioning

confidence: 99%

Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status

Mittag

Proietto

Loudovaris

et al. 2011

The Journal of Immunology

212

195

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Mouse dendritic cells (DC) have been extensively studied in various tissues, especially spleen, and they comprise subsets with distinct developmental origins, surface phenotypes, and functions. Considerably less is known about human DC due to their rarity in blood and inaccessibility of other human tissues. The study of DC in human blood has revealed four subsets distinct in phenotype and function. In this study, we describe four equivalent DC subsets in human spleen obtained from deceased organ donors. We identify three conventional DC subsets characterized by surface expression of CD1b/c, CD141, and CD16, and one plasmacytoid DC subset characterized by CD304 expression. Human DC subsets in spleen were very similar to those in human blood with respect to surface phenotype, TLR and transcription factor expression, capacity to stimulate T cells, cytokine secretion, and cross-presentation of exogenous Ag. However, organ donor health status, in particular treatment with corticosteroid methylprednisolone and brain death, may affect DC phenotype and function. DC T cell stimulatory capacity was reduced but DC were qualitatively unchanged in methylprednisolone-treated deceased organ donor spleen compared with healthy donor blood. Overall, our findings indicate that human blood DC closely resemble human spleen DC. Furthermore, we confirm parallels between human and mouse DC subsets in phenotype and function, but also identify differences in transcription factor and TLR expression as well as functional properties. In particular, the hallmark functions of mouse CD8α+ DC subsets, that is, IL-12p70 secretion and cross-presentation, are not confined to the equivalent human CD141+ DC but are shared by CD1b/c+ and CD16+ DC subsets.

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Human spleen contains different subsets of dendritic cells and regulatory T lymphocytes

Cited by 53 publications

References 37 publications

Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases

Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases

Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells

Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status

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