Human T-Lymphotropic Virus Type 1 and Type 2 Seroprevalence, Incidence, and Residual Transfusion Risk Among Blood Donors in Brazil During 2007–2009

Carneiro-Proietti, Anna Bárbara F.; Sabino, Éster Cerdeira; Leão, Silvana Carneiro; Salles, Nanci Alves; Loureiro, Paula; Sarr, Moussa; Wright, David J.; Busch, Michael P.; Proietti, Fernando Augusto; Murphy, Edward L.

doi:10.1089/aid.2011.0143

Cited by 50 publications

(58 citation statements)

References 27 publications

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“…In the comparison between HTLV-1/2 positive and negative groups none of the variables was statistically significant, which was in line with the two latest studies from Bahia [20], [21]. Although there were some reports of an inverse association between both length of formal education and family income with HTLV-1/2 infection [7], [18], [19], [23]–[26] these were not universal findings [15], [21], [27]–[30] and were not confirmed in our population.…”

Section: Discussionsupporting

confidence: 87%

Prevalence of HTLV-1/2 in Pregnant Women Living in the Metropolitan Area of Rio de Janeiro

et al. 2014

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BackgroundHTLV-1/2 infection can cause severe and disabling diseases in children and adults. The aim of the study was to estimate the prevalence of HTLV-1/2 infection in pregnant women living in the metropolitan area of Rio de Janeiro.Methodology/Principal Findings1,204 pregnant women were tested upon hospital admission for delivery in two public hospitals in the cities of Rio de Janeiro and Mesquita, between November, 2012 and April, 2013. The samples were screened by chemiluminescent microparticle immunoassay (CMIA) and reactive ones were confirmed by Western blot (WB). Epi-info software was used for building the database and performing the statistical analysis. Eight patients had confirmed HTLV-1/2 infection (7 HTLV-1, one HTLV-2), equivalent to a prevalence rate of 0.66%. Two further reactive screening tests had negative Western blot results and therefore were considered negative in the statistical analysis. All HTLV-1/2-positive patients were born in Rio de Janeiro, most were non-Caucasian (87.5%), in a stable relationship (62.5%), had at least ten years of formal education (62.5%) and a monthly family income of up to US$600.00 (87.5%). There was only one case of coinfection with syphilis and none with HIV. The mean age of the infected women was 28.4 (SD = 6.3) years and of the seronegative ones was 24.8 (SD = 6.5) (p = 0.10). The median number of pregnancies were 3.0 and 1.0 (p = 0.06) and the median number of sexual partners were 3.5 and 3.0 (p = 0.33) in the seropositive and negative groups, respectively. There were no statistically significant differences between the groups.Conclusions/SignificanceA significant prevalence of HTLV-1/2 was found in our population. The socio-epidemiological profile of carrier mothers was similar to the controls. Such findings expose the need for a public health policy of routine HTLV-1/2 screening in antenatal care, since counselling and preventive measures are the only strategies currently available to interrupt the chain of transmission and the future development of HTLV-1/2-related diseases.

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Section: Discussionsupporting

confidence: 87%

Prevalence of HTLV-1/2 in Pregnant Women Living in the Metropolitan Area of Rio de Janeiro

et al. 2014

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“…Al comparar los resultados obtenidos en las pruebas de tamización durante los 13 años del periodo analizado, se pudo estimar una tasa de 303 unidades reactivas por cada 100.000 tamizadas, lo cual contrasta con el estudio de Carneiro, et al, en una población de donantes de primera vez en Brasil entre 2007 y 2009, en el cual se reportó una tasa de 135 unidades reactivas por 100.000 unidades tamizadas (24).…”

Section: Discussionunclassified

“…Cuando se constata que la tasa calculada en Colombia es comparable con la de Brasil, país considerado endémico para el virus, cobra mayor relevancia la investigación poblacional (24).…”

Section: Discussionunclassified

Prevalencia de la infección con el virus linfotrópico de células T humanas de tipo 1 y 2 en donantes de sangre en Colombia, 2001-2014: implicaciones sobre la seguridad de la transfusión

Bermúdez-Forero¹,

Berrío-Pérez²,

Herrera-Hernández³

et al. 2016

biomedica

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conceptual y apoyo en el análisis de los datos Todos los autores participaron en la revisión crítica del documento y en la escritura del manuscrito. Materiales y métodos. Se hizo un análisis descriptivo y retrospectivo de la información enviada por la Red de Bancos de Sangre al Instituto Nacional de Salud sobre tamización, unidades reactivas y positividad para el HTLV 1 y 2 y sobre la estimación de riesgo de infección por la transfusión. Prevalencia de la infección con el virus linfotrópico de célulasResultados. Entre 2001 y 2014 se hizo en Colombia la tamización para la detección de anticuerpos de HTLV 1 y 2 de 60,2 % de la sangre captada, con una tasa acumulada de unidades reactivas de 0,3 %. Dicha tasa fue 20 veces superior en el departamento de Chocó (6,28 %), pese a que allí no se capta sangre desde el 2004. En el 2014, la tamización llegó a 94,9 %, con una positividad de 14,7 %. Con estos datos se pudo estimar que se transfundieron 406 unidades de glóbulos rojos potencialmente infecciosos, lo cual entrañaría una transmisión eficaz del virus a estos individuos. Pese a que no se le considera un departamento endémico, en Antioquia se registró la mayor proporción de pruebas positivas, con 215 unidades (53 %). Conclusiones. Los resultados obtenidos sugieren que la infección por HTLV 1 y 2 se distribuye en varias zonas del país que no eran catalogadas como endémicas. Se ratificó la importancia de la tamización universal de las unidades de sangre captadas, para minimizar el riesgo de infección con este agente por la vía de la transfusión.Palabras clave: virus 1 linfotrópico T humano, transfusión sanguínea, bancos de sangre, donantes de sangre, prevalencia, Colombia.

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“…Two studies that have been conducted during different periods assessing blood donors from São Paulo have reported prevalences of 0.32% and 0.1% from 1995 to 2000 and from 2007 to 2009, respectively. 17,18 Until now, the only study of HTLV prevalence in the general population of Brazil was conducted in Salvador, Bahia, 19 preventing comparative analysis between the general population and the HIV-infected population from São Paulo. Future studies investigating whether the decrease in HTLV prevalence in the general population accounts for the reduction in HTLV prevalence among HIV-infected individuals are warranted.…”

Section: Discussionmentioning

confidence: 99%

Short Communication: Current Prevalence and Risk Factors Associated with Human T Lymphotropic Virus Type 1 and Human T Lymphotropic Virus Type 2 Infections Among HIV/AIDS Patients in São Paulo, Brazil

Caterino–de–Araujo

Sacchi²,

Gonçalves³

et al. 2015

AIDS Research and Human Retroviruses

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During the 1990s, high prevalences of HIV/human T lymphotropic virus type 1 (HTLV-1) and HIV/human T lymphotropic virus type 2 (HTLV-2) coinfections were detected in São Paulo, Brazil in association with intravenous drug use (IDU). The current prevalences and risk factors for HIV/HTLV-1/-2 were evaluated in 1,608 patients attending the AIDS/STD Reference and Training Center in São Paulo. Blood samples were analyzed for HTLV-1/2-specific antibodies using enzyme immunoassays (EIA Murex HTLV-I + II, Diasorin, and Gold ELISA HTLV-I + II, REM) and immunoblotting (HTLV Blot 2.4, MP Biomedicals and INNO-LIA HTLV-I/II, Innogenetics) and for the pol proviral DNA segments of HTLV-1 and HTLV-2 by ''in-house'' realtime PCR. These analyses revealed that 50 (3.11%) of the samples were HTLV positive, including 25 (1.55%) that were HTLV-1 positive, 21 (1.31%) that were HTLV-2 positive, and 4 (0.25%) that were HTLV positive (untypeable). The median age of the HIV/HTLV-coinfected individuals was 50 years versus 44 years in the overall population ( p = 0.000). The risk factors associated with HIV/HTLV-1/-2 coinfections were female gender (OR 3.26, 1.78-5.95), black/pardo color (OR 2.21, 1.21-4.03), infection with hepatitis B virus (HBV) (OR 4.27,) or hepatitis C virus (HCV) (OR 24.40,, and intravenous drug use (IDU) (OR 30.01,. The current low prevalence of HTLV-1/2 in HIV-infected patients in São Paulo could be explained in part by programs providing IDUs with sterile needles and syringes and changes in the drug usage patterns of individuals from injecting cocaine to smoking crack cocaine.

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Human T-Lymphotropic Virus Type 1 and Type 2 Seroprevalence, Incidence, and Residual Transfusion Risk Among Blood Donors in Brazil During 2007–2009

Cited by 50 publications

References 27 publications

Prevalence of HTLV-1/2 in Pregnant Women Living in the Metropolitan Area of Rio de Janeiro

Prevalence of HTLV-1/2 in Pregnant Women Living in the Metropolitan Area of Rio de Janeiro

Prevalencia de la infección con el virus linfotrópico de células T humanas de tipo 1 y 2 en donantes de sangre en Colombia, 2001-2014: implicaciones sobre la seguridad de la transfusión

Short Communication: Current Prevalence and Risk Factors Associated with Human T Lymphotropic Virus Type 1 and Human T Lymphotropic Virus Type 2 Infections Among HIV/AIDS Patients in São Paulo, Brazil

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