Human Tissue Reaction to Sutures

Postlethwait, R. W.; Willigan, Donald A.; Ulin, Alex W.

doi:10.1097/00000658-197502000-00003

Cited by 158 publications

(31 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from limitations of animal experiments, these foreign body reactions appear quite similar to those seen in humans [13,28]. Considering our expectation that a CTI reflects tension and the fact that we placed the suture without any mechanical strain, we were surprised by the fact that all sutures still showed a pronounced bilateral CTI.…”

Section: Discussionmentioning

confidence: 72%

“…In the majority of these studies tension was applied to the suture [9,10,11,12]. However, Postlethwaite et al [13 ]already noted acellular fibrous tissue on the side of the suture toward the tension; while opposite to the direction of tension there resulted a cellular infiltrate marking the path of the migrating and thus cutting action. In a study of Hoer et al, this was confirmed, and because of the characteristic shape, it was named ‘comet tail phenomenon’ [14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comet-Tail-Like Inflammatory Infiltrate to Polymer Filaments Develops in Tension-Free Conditions

Klink¹,

Binnebösel²,

Kaemmer³

et al. 2010

Eur Surg Res

View full text Add to dashboard Cite

Background: Mesh reinforcement in hiatal hernia repair becomes more frequent but is charged by complications such as erosion or stenosis of the oesophagus. These complications are accompanied by an intense inflammatory infiltrate around the polymer fibres. To characterize this effect, the response to polypropylene fibres in the absence of tension was examined. Methods: In rats, polypropylene sutures (USP size 1, 3-0 and 7-0) were placed in the subcutis of the abdominal wall without knot or tension. On postoperative days 3, 7 and 21, specimens were excised. The expressions of c-myc, β-catenin, Notch3, COX-2, CD68 and Ki-67 were measured by immunohistochemistry. Results: In the absence of tension, sutures were surrounded by a foreign body granuloma with an inflammatory infiltrate not encircling the fibre but forming almost symmetric comet-tail-like infiltrates on opposite sides. The expression of c-myc, β-catenin, Notch3, COX-2, CD68 and Ki-67 was significantly reduced over time in the comet tail, but not in the granuloma. Conclusions: Even in tension-free conditions, surgical sutures cause a foreign body response with infiltrates of inflammatory cells. This reaction is shaped like a comet tail, and its extension depends on the diameter of the used fibre. Therefore, for reduction of perifilamental infiltrates, not only absence of tension is required, but also a small-sized fibre textile.

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Comet-Tail-Like Inflammatory Infiltrate to Polymer Filaments Develops in Tension-Free Conditions

Klink¹,

Binnebösel²,

Kaemmer³

et al. 2010

Eur Surg Res

View full text Add to dashboard Cite

show abstract

“…Peak inflammatory response is seen between second and seventh day with abundance of polymorphonuclear leukocytes, lymphocytes, and large monocytes in dermis. [3] Between the third and eighth day, the epithelial cells deeply invade the suture tracts.…”

Section: Basic Characteristics Of Wound Healing After Basic Charactermentioning

confidence: 99%

“…It passes through the tissue more easily but knot security is inferior. Absorption of Glycomer 631 [3,4] is complete between 90 and 110 days.…”

Section: Glycomer 631mentioning

confidence: 99%

Sutures and suturing techniques in skin closure

Kudur

Pai

Sripathi

et al. 2009

Indian J Dermatol Venereol Leprol

100

View full text Add to dashboard Cite

show abstract

“…5,6 The numerous options for wound closure are well described in the plastic and dermatological surgery literature and include suture, staples, adhesive tapes and glues. 4,39,40,45 A review of the orthopaedic literature for calcaneal fractures, tibial plafond fractures, and fracture-dislocations of the ankle reveals that nylon suture is the most common choice to close the skin. 14,27,44,46 Basic science investigations evaluating the characteristics of closure materials generally support the use of nylon suture or staples.…”

Section: Wound Closure Materialsmentioning

confidence: 99%